ENSMUSG00000035783


Mus musculus

Features
Gene ID: ENSMUSG00000035783
  
Biological name :Acta2
  
Synonyms : Acta2 / Actin, aortic smooth muscle Actin, aortic smooth muscle, intermediate form / P62737
  
Possible biological names infered from orthology : actin, alpha 2, smooth muscle, aorta / P62736
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C1
Gene start: 34241090
Gene end: 34255336
  
Corresponding Affymetrix probe sets: 10467124 (MoGene1.0st)   1416454_s_at (Mouse Genome 430 2.0 Array)   1444105_at (Mouse Genome 430 2.0 Array)   1456658_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048218
NCBI entrez gene - 11475     See in Manteia.
MGI - MGI:87909
RefSeq - NM_007392
RefSeq - XM_006526606
RefSeq Peptide - NP_031418
swissprot - P62737
Ensembl - ENSMUSG00000035783
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acta2ENSDARG00000045180Danio rerio
 ACTA2ENSGALG00000006343Gallus gallus
 ACTA2ENSG00000107796Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Actg2 / P63268 / Actin, gamma-enteric smooth muscle / P63267* / actin, gamma 2, smooth muscle, enteric*ENSMUSG0000005943099
Acta1 / P68134 / Actin, alpha skeletal muscle / P68133* / actin, alpha 1, skeletal muscle*ENSMUSG0000003197298
Actc1 / P68033 / Actin, alpha cardiac muscle 1 / P68032*ENSMUSG0000006861498
Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*ENSMUSG0000006282594
Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*ENSMUSG0000002958093
Actbl2 / Q8BFZ3 / Beta-actin-like protein 2 / Q562R1* / actin, beta like 2*ENSMUSG0000005519489
Actr1b / Q8R5C5 / Beta-centractin / P42025* / ARP1 actin related protein 1 homolog B*ENSMUSG0000003735154
Actr1a / P61164 / Alpha-centractin / P61163* / ARP1 actin related protein 1 homolog A*ENSMUSG0000002522853
Gm498ENSMUSG0000003108549
Actrt2 / Q9D9L5 / Actin-related protein T2 / Q8TDY3*ENSMUSG0000005127649
Actrt1 / Q9D9J3 / Actin-related protein T1 / Q8TDG2*ENSMUSG0000004661547
Actrt3 / Q8BXF8 / Actin-related protein T3 / Q9BYD9*ENSMUSG0000003773745
Actl7a / Q9QY84 / actin-like 7a / Q9Y615*ENSMUSG0000007097944
Actl7b / Q9QY83 / actin-like 7b / Q9Y614*ENSMUSG0000007098043
Actl9 / Q8CG27 / Actin-like protein 9 / Q8TC94* / actin like 9*ENSMUSG0000009251940
Actl11 / actin-like 11ENSMUSG0000006636838


Protein motifs (from Interpro)
Interpro ID Name
 IPR004000  Actin family
 IPR004001  Actin, conserved site
 IPR020902  Actin/actin-like conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008217 regulation of blood pressure IMP
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0014829 vascular smooth muscle contraction IMP
 biological_processGO:0072144 glomerular mesangial cell development IEA
 biological_processGO:0090131 mesenchyme migration ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IDA
 cellular_componentGO:0015629 actin cytoskeleton ISO
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0030175 filopodium ISS
 cellular_componentGO:0030485 smooth muscle contractile fiber IDA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0044297 cell body ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
Smooth Muscle Contraction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il12btm1Jm/Il12btm1Jm
Genetic Background: 129S1/Sv-Il12btm1Jm

 MP:0000233 abnormal blood flow velocity "anomalous rate of flow of the blood through vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il12btm1Jm/Il12btm1Jm
Genetic Background: 129S1/Sv-Il12btm1Jm

 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il12btm1Jm/Il12btm1Jm
Genetic Background: 129S1/Sv-Il12btm1Jm

 MP:0003026 decreased vascular smooth muscle contraction "reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Il12btm1Jm/Il12btm1Jm
Genetic Background: 129S1/Sv-Il12btm1Jm

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Il12btm1Jm/Il12btm1Jm
Genetic Background: 129S1/Sv-Il12btm1Jm

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Il12btm1Jm/Il12btm1Jm
Genetic Background: 129S1/Sv-Il12btm1Jm

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Il12btm1Jm/Il12btm1Jm
Genetic Background: 129S1/Sv-Il12btm1Jm

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
Show

Allelic Composition: Il12btm1Jm/Il12btm1Jm
Genetic Background: 129S1/Sv-Il12btm1Jm

 MP:0009862 abnormal aorta elastic tissue morphology "any structural anomaly of the dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il12btm1Jm/Il12btm1Jm
Genetic Background: 129S1/Sv-Il12btm1Jm

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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