ENSMUSG00000068614


Mus musculus

Features
Gene ID: ENSMUSG00000068614
  
Biological name :Actc1
  
Synonyms : Actc1 / Actin, alpha cardiac muscle 1 / P68033
  
Possible biological names infered from orthology : P68032
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E4
Gene start: 114047282
Gene end: 114053548
  
Corresponding Affymetrix probe sets: 10485982 (MoGene1.0st)   1415927_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000087736
Ensembl peptide - ENSMUSP00000123370
NCBI entrez gene - 11464     See in Manteia.
MGI - MGI:87905
RefSeq - NM_009608
RefSeq Peptide - NP_033738
swissprot - F6WX90
swissprot - P68033
swissprot - Q497E4
Ensembl - ENSMUSG00000068614
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acta2ENSDARG00000099197Danio rerio
 ACTC1ENSDARG00000057911Danio rerio
 actc1aENSDARG00000042535Danio rerio
 actc1aENSDARG00000076126Danio rerio
 ACTC1ENSGALG00000009844Gallus gallus
 ACTC1ENSG00000159251Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Acta1 / P68134 / Actin, alpha skeletal muscle / P68133* / actin, alpha 1, skeletal muscle*ENSMUSG0000003197299
Actg2 / P63268 / Actin, gamma-enteric smooth muscle / P63267* / actin, gamma 2, smooth muscle, enteric*ENSMUSG0000005943099
Acta2 / P62737 / Actin, aortic smooth muscle Actin, aortic smooth muscle, intermediate form / P62736* / actin, alpha 2, smooth muscle, aorta*ENSMUSG0000003578398
Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*ENSMUSG0000002958094
Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*ENSMUSG0000006282593
Actbl2 / Q8BFZ3 / Beta-actin-like protein 2 / Q562R1* / actin, beta like 2*ENSMUSG0000005519489
Actr1a / P61164 / Alpha-centractin / P61163* / ARP1 actin related protein 1 homolog A*ENSMUSG0000002522853
Actr1b / Q8R5C5 / Beta-centractin / P42025* / ARP1 actin related protein 1 homolog B*ENSMUSG0000003735153
Actrt2 / Q9D9L5 / Actin-related protein T2 / Q8TDY3*ENSMUSG0000005127649
Gm498ENSMUSG0000003108548
Actrt1 / Q9D9J3 / Actin-related protein T1 / Q8TDG2*ENSMUSG0000004661547
Actrt3 / Q8BXF8 / Actin-related protein T3 / Q9BYD9*ENSMUSG0000003773745
Actl7a / Q9QY84 / actin-like 7a / Q9Y615*ENSMUSG0000007097944
Actl7b / Q9QY83 / actin-like 7b / Q9Y614*ENSMUSG0000007098043
Actl9 / Q8CG27 / Actin-like protein 9 / Q8TC94* / actin like 9*ENSMUSG0000009251940
Actl11 / actin-like 11ENSMUSG0000006636838


Protein motifs (from Interpro)
Interpro ID Name
 IPR004000  Actin family
 IPR004001  Actin, conserved site
 IPR020902  Actin/actin-like conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0030048 actin filament-based movement IEA
 biological_processGO:0030240 skeletal muscle thin filament assembly IMP
 biological_processGO:0031032 actomyosin structure organization IMP
 biological_processGO:0033275 actin-myosin filament sliding IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0055003 cardiac myofibril assembly IMP
 biological_processGO:0055008 cardiac muscle tissue morphogenesis IMP
 biological_processGO:0060047 heart contraction IEA
 biological_processGO:0060048 cardiac muscle contraction IEA
 biological_processGO:0070252 actin-mediated cell contraction IMP
 biological_processGO:0090131 mesenchyme migration ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0030017 sarcomere IEA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0030175 filopodium ISS
 cellular_componentGO:0031674 I band IDA
 cellular_componentGO:0042643 actomyosin, actin portion IEA
 cellular_componentGO:0044297 cell body ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0017022 myosin binding IEA


Pathways (from Reactome)
Pathway description
Striated Muscle Contraction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

Allelic Composition: Actc1tm1Jll/Actc1tm1Jll,Tg(Myh6-Actg2)1Jll/0
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0000749 muscle degeneration "pathological deterioration of muscle tissue, often accompanied by loss of function" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smpd1tm1Wst/Smpd1tm1Wst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Actc1tm1Jll/Actc1tm1Jll,Tg(Myh6-Actg2)1Jll/0
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Actc1tm1Jll/Actc1tm1Jll,Tg(Myh6-Actg2)1Jll/0
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Actc1tm1Jll/Actc1tm1Jll,Tg(Myh6-Actg2)1Jll/0
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Actc1tm1Jll/Actc1tm1Jll,Tg(Myh6-Actg2)1Jll/0
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Actc1tm1Jll/Actc1tm1Jll,Tg(Myh6-Actg2)1Jll/0
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0004566 myocardial fiber degeneration "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Actc1tm1Jll/Actc1tm1Jll,Tg(Myh6-Actg2)1Jll/0
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Actc1tm1Jll/Actc1tm1Jll,Tg(Myh6-Actg2)1Jll/0
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0012082 delayed heart development "late onset of the induction and/or differentiation of the heart" [MGI:anna]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0020409 abnormal cardiac thrombosis "any anomaly in the formation or presence of thrombi in the heart" [PMID:15870284]
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Allelic Composition: Actc1tm1Jll/Actc1tm1Jll,Tg(Myh6-Actg2)1Jll/0
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000068614 Actc1 / P68033 / Actin, alpha cardiac muscle 1 / P68032*  / -
 ENSMUSG00000031972 Acta1 / P68134 / Actin, alpha skeletal muscle / P68133* / actin, alpha 1, skeletal muscle*  / -






 

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