ENSMUSG00000031972


Mus musculus

Features
Gene ID: ENSMUSG00000031972
  
Biological name :Acta1
  
Synonyms : Acta1 / Actin, alpha skeletal muscle / P68134
  
Possible biological names infered from orthology : actin, alpha 1, skeletal muscle / P68133
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: E2
Gene start: 123891769
Gene end: 123894751
  
Corresponding Affymetrix probe sets: 10582592 (MoGene1.0st)   1427735_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034453
Ensembl peptide - ENSMUSP00000148594
NCBI entrez gene - 11459     See in Manteia.
MGI - MGI:87902
RefSeq - NM_001272041
RefSeq - NM_009606
RefSeq Peptide - NP_001258970
RefSeq Peptide - NP_033736
swissprot - P68134
swissprot - A0A1D5RM20
Ensembl - ENSMUSG00000031972
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ACTA1ENSG00000143632Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Actc1 / P68033 / Actin, alpha cardiac muscle 1 / P68032*ENSMUSG0000006861499
Actg2 / P63268 / Actin, gamma-enteric smooth muscle / P63267* / actin, gamma 2, smooth muscle, enteric*ENSMUSG0000005943098
Acta2 / P62737 / Actin, aortic smooth muscle Actin, aortic smooth muscle, intermediate form / P62736* / actin, alpha 2, smooth muscle, aorta*ENSMUSG0000003578398
Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*ENSMUSG0000006282593
Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*ENSMUSG0000002958093
Actbl2 / Q8BFZ3 / Beta-actin-like protein 2 / Q562R1* / actin, beta like 2*ENSMUSG0000005519489
Actr1b / Q8R5C5 / Beta-centractin / P42025* / ARP1 actin related protein 1 homolog B*ENSMUSG0000003735153
Actr1a / P61164 / Alpha-centractin / P61163* / ARP1 actin related protein 1 homolog A*ENSMUSG0000002522852
Actrt2 / Q9D9L5 / Actin-related protein T2 / Q8TDY3*ENSMUSG0000005127649
Gm498ENSMUSG0000003108548
Actrt1 / Q9D9J3 / Actin-related protein T1 / Q8TDG2*ENSMUSG0000004661547
Actrt3 / Q8BXF8 / Actin-related protein T3 / Q9BYD9*ENSMUSG0000003773745
Actl7a / Q9QY84 / actin-like 7a / Q9Y615*ENSMUSG0000007097943
Actl7b / Q9QY83 / actin-like 7b / Q9Y614*ENSMUSG0000007098042
Actl9 / Q8CG27 / Actin-like protein 9 / Q8TC94* / actin like 9*ENSMUSG0000009251940
Actl11 / actin-like 11ENSMUSG0000006636837


Protein motifs (from Interpro)
Interpro ID Name
 IPR004000  Actin family
 IPR004001  Actin, conserved site
 IPR020902  Actin/actin-like conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009991 response to extracellular stimulus IEA
 biological_processGO:0010226 response to lithium ion IEA
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0030240 skeletal muscle thin filament assembly IEA
 biological_processGO:0043503 skeletal muscle fiber adaptation IEA
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0048741 skeletal muscle fiber development IDA
 biological_processGO:0071417 cellular response to organonitrogen compound IEA
 biological_processGO:0090131 mesenchyme migration ISS
 cellular_componentGO:0001725 stress fiber IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005865 striated muscle thin filament IEA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0030017 sarcomere IEA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0030175 filopodium ISS
 cellular_componentGO:0044297 cell body ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Striated Muscle Contraction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000161 scoliosis "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]
Show

Allelic Composition: Acrtm1Tba/Acrtm1Tba
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * ICR)

 MP:0000733 abnormal muscle development "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Acrtm1Tba/Acrtm1Tba
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * ICR)

 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Acrtm1Tba/Acrtm1Tba
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * ICR)

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Acta1tm1Jll/Acta1+,Tg(ACTA1*D286G)#Kjno/Tg(ACTA1*D286G)#Kjno
Genetic Background: involves: C57BL/6 * CBA

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Acta1tm1Jll/Acta1+,Tg(ACTA1*D286G)#Kjno/Tg(ACTA1*D286G)#Kjno
Genetic Background: involves: C57BL/6 * CBA

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Acrtm1Tba/Acrtm1Tba
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * ICR)

Allelic Composition: Acta1tm1Hrd/Acta1+
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

Allelic Composition: Acta1tm1Jll/Acta1+,Tg(ACTA1*D286G)#Kjno/Tg(ACTA1*D286G)#Kjno
Genetic Background: involves: C57BL/6 * CBA

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Acrtm1Tba/Acrtm1Tba
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * ICR)

 MP:0001344 blepharoptosis "ptosis, drooping eyelids " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:24414]
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Allelic Composition: Acta1tm1Hrd/Acta1+
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

 MP:0001349 excessive tearing "an unusually high amount of fluid secreted by the lacrimal glands, often resulting in overflow of fluid from the eye" [hdene:Howard Dene, Mouse Genome Informatics Curator, J:38104]
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Allelic Composition: Acta1tm1Hrd/Acta1+
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(MSV-SKI)33Hugh/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

 MP:0001515 abnormal grip strength "altered ability to grasp and hold objects, usually measured as time spent hanging from an object or wire" [J:80661]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(MSV-SKI)33Hugh/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Acrtm1Tba/Acrtm1Tba
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * ICR)

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Acta1tm1Jll/Acta1+,Tg(ACTA1*D286G)#Kjno/Tg(ACTA1*D286G)#Kjno
Genetic Background: involves: C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tcf3tm5.1Cmu/Tcf3tm5.1Cmu
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(Myl1-Igf1)1Nros/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * FVB/N) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc * FVB/N)

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(ACTA1-FHL1)#Cmit/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * FVB/N) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc * FVB/N)

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(MSV-SKI)33Hugh/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

Allelic Composition: Acta1tm1Jll/Acta1+,Tg(ACTA1*D286G)#Kjno/Tg(ACTA1*D286G)#Kjno
Genetic Background: involves: C57BL/6 * CBA

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acrtm1Tba/Acrtm1Tba
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * ICR)

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Acrtm1Tba/Acrtm1Tba
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * ICR)

 MP:0004087 abnormal muscle fiber morphology "malformed or poorly developed muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(Myl1-Igf1)1Nros/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * FVB/N) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc * FVB/N)

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(ACTA1-FHL1)#Cmit/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * FVB/N) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc * FVB/N)

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(MSV-SKI)33Hugh/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

Allelic Composition: Acta1tm1Jll/Acta1+,Tg(ACTA1*D286G)#Kjno/Tg(ACTA1*D286G)#Kjno
Genetic Background: involves: C57BL/6 * CBA

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

 MP:0004091 abnormal Z lines "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Acta1tm1Jll/Acta1+,Tg(ACTA1*D286G)#Kjno/Tg(ACTA1*D286G)#Kjno
Genetic Background: involves: C57BL/6 * CBA

 MP:0004232 decreased muscle weight "less than average muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

 MP:0004233 abnormal muscle weight "any anomaly in the average muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(Myl1-Igf1)1Nros/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * FVB/N) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc * FVB/N)

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(ACTA1-FHL1)#Cmit/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * FVB/N) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc * FVB/N)

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(MSV-SKI)33Hugh/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Acrtm1Tba/Acrtm1Tba
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * ICR)

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acrtm1Tba/Acrtm1Tba
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * ICR)

 MP:0009403 increased variability of skeletal muscle fiber size "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acta1tm1Jll/Acta1+,Tg(ACTA1*D286G)#Kjno/Tg(ACTA1*D286G)#Kjno
Genetic Background: involves: C57BL/6 * CBA

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(Myl1-Igf1)1Nros/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * FVB/N) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc * FVB/N)

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(ACTA1-FHL1)#Cmit/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * FVB/N) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc * FVB/N)

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

 MP:0010398 decreased liver glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acrtm1Tba/Acrtm1Tba
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * ICR)

 MP:0010399 decreased skeletal muscle glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acrtm1Tba/Acrtm1Tba
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * ICR)

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Acrtm1Tba/Acrtm1Tba
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * ICR)

 MP:0030140 facial muscle atrophy "acquired diminution of facial muscle tissue associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes; occurs with age, immobilization, weightlessness, malnutrition or denervation" [MGI:anna]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031972 Acta1 / P68134 / Actin, alpha skeletal muscle / P68133* / actin, alpha 1, skeletal muscle*  / -
 ENSMUSG00000068614 Actc1 / P68033 / Actin, alpha cardiac muscle 1 / P68032*  / -






 

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