ENSMUSG00000026532


Mus musculus

Features
Gene ID: ENSMUSG00000026532
  
Biological name :Spta1
  
Synonyms : P08032 / Spectrin alpha chain, erythrocytic 1 / Spta1
  
Possible biological names infered from orthology : P02549 / spectrin alpha, erythrocytic 1
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H3
Gene start: 174172776
Gene end: 174248450
  
Corresponding Affymetrix probe sets: 10351905 (MoGene1.0st)   1421277_at (Mouse Genome 430 2.0 Array)   1421278_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027817
NCBI entrez gene - 20739     See in Manteia.
MGI - MGI:98385
RefSeq - NM_011465
RefSeq Peptide - NP_035595
swissprot - P08032
Ensembl - ENSMUSG00000026532
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sptan1ENSDARG00000019231Danio rerio
 SPTA1ENSG00000163554Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P16546 / Sptan1 / Spectrin alpha chain, non-erythrocytic 1 / Q13813* / spectrin alpha, non-erythrocytic 1*ENSMUSG0000005773855
Sptbn2 / spectrin beta, non-erythrocytic 2 / O15020*ENSMUSG0000006788920
Q62261 / Sptbn1 / Spectrin beta chain, non-erythrocytic 1 / Q01082* / spectrin beta, non-erythrocytic 1*ENSMUSG0000002031520
Sptb / spectrin beta, erythrocytic / P11277*ENSMUSG0000002106119
Sptbn4 / spectrin beta, non-erythrocytic 4 / Q9H254*ENSMUSG0000001175118
Actn4 / P57780 / Alpha-actinin-4 / O43707* / actinin alpha 4*ENSMUSG000000548086
Actn3 / O88990 / Alpha-actinin-3 / Q08043* / actinin alpha 3 (gene/pseudogene)*ENSMUSG000000064576
Actn1 / Q7TPR4 / Mus musculus actinin, alpha 1 (Actn1), transcript variant 2, mRNA. / P12814* / actinin alpha 1*ENSMUSG000000151436
Actn2 / Q9JI91 / Alpha-actinin-2 / P35609* / actinin alpha 2*ENSMUSG000000523746


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR002017  Spectrin repeat
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR014837  EF-hand, Ca insensitive
 IPR018159  Spectrin/alpha-actinin
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002260 lymphocyte homeostasis IMP
 biological_processGO:0006779 porphyrin-containing compound biosynthetic process IMP
 biological_processGO:0007009 plasma membrane organization IMP
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0030036 actin cytoskeleton organization IMP
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0032092 positive regulation of protein binding IGI
 biological_processGO:0042102 positive regulation of T cell proliferation IMP
 biological_processGO:0051693 actin filament capping IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0008091 spectrin TAS
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0014731 spectrin-associated cytoskeleton ISO
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030863 cortical cytoskeleton IDA
 cellular_componentGO:0032437 cuticular plate IDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
NCAM signaling for neurite out-growth
Interaction between L1 and Ankyrins
RAF/MAP kinase cascade
COPI-mediated anterograde transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000172 abnormal bone marrow cell number "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: either: (B6.C3-Spta1sph x WB.C3-Spta1sph)F1 or (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: involves: DBA/1J

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: either: (B6.C3-Spta1sph x WB.C3-Spta1sph)F1 or (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

Allelic Composition: Spta1sph-3J/Spta1sph-3J
Genetic Background: NOD.Cg-H2b Spta1sph-3J

Allelic Composition: Spta1sph-4J/Spta1sph-4J
Genetic Background: C57BL/6J-Spta1sph-4J/Llp

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

Allelic Composition: Spta1sph-3J/Spta1sph-3J
Genetic Background: NOD.Cg-H2b Spta1sph-3J

Allelic Composition: Spta1sph-4J/Spta1sph-4J
Genetic Background: C57BL/6J-Spta1sph-4J/Llp

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: either: (B6.C3-Spta1sph x WB.C3-Spta1sph)F1 or (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0000248 macrocytosis "condition in which erythrocytes are larger than normal in size" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: either: (B6.C3-Spta1sph x WB.C3-Spta1sph)F1 or (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0000255 vasculature congestion "obstruction of the normal flux of blood within the blood vessel network" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0000314 schistocytosis "the appearance of poikilocytes in the blood that owe their abnormal shape to fragmentation occurring as the cells flow through damaged small vessels" [J:82330, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: involves: DBA/1J

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: either: (B6.C3-Spta1sph x WB.C3-Spta1sph)F1 or (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0000422 delayed hair appearance "late onset of the first appearance of the fur" [J:17792]
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Allelic Composition: Spta1ihj/Spta1ihj
Genetic Background: involves: HRS/J * LAH

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: involves: DBA/1J

Allelic Composition: Spta1ihj/Spta1ihj
Genetic Background: involves: HRS/J * LAH

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0000602 enlarged sinusoidal spaces "larger than normal sized cavities in the liver " [J:23170]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000611 jaundice "clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: involves: DBA/1J

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Spta1ihj/Spta1ihj
Genetic Background: involves: HRS/J * LAH

Allelic Composition: Spta1sph-Dem/Spta1sph-Dem
Genetic Background: CcS3/Dem-Spta1sph-Dem

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: involves: DBA/1J

Allelic Composition: Spta1ihj/Spta1ihj
Genetic Background: involves: HRS/J * LAH

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: either: (B6.C3-Spta1sph x WB.C3-Spta1sph)F1 or (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: involves: DBA/1J

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Spta1ihj/Spta1ihj
Genetic Background: involves: HRS/J * LAH

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: either: (B6.C3-Spta1sph x WB.C3-Spta1sph)F1 or (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

Allelic Composition: Spta1sph-Dem/Spta1sph-Dem
Genetic Background: CcS3/Dem-Spta1sph-Dem

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

Allelic Composition: Spta1sph-3J/Spta1sph-3J
Genetic Background: NOD.Cg-H2b Spta1sph-3J

Allelic Composition: Spta1sph-4J/Spta1sph-4J
Genetic Background: C57BL/6J-Spta1sph-4J/Llp

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Rettm9(RET)Jmi/Rettm9(RET)Jmi
Genetic Background: involves: 129X1/SvJ * 129S1/Sv * C57BL/6

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Spta1ihj/Spta1ihj
Genetic Background: involves: HRS/J * LAH

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Spta1sph-Dem/Spta1sph-Dem
Genetic Background: CcS3/Dem-Spta1sph-Dem

Allelic Composition: Spta1sph-3J/Spta1sph-3J
Genetic Background: NOD.Cg-H2b Spta1sph-3J

Allelic Composition: Spta1sph-4J/Spta1sph-4J
Genetic Background: C57BL/6J-Spta1sph-4J/Llp

 MP:0001585 hemolytic anemia "an anemic condition resulting from an increased rate of erythrocyte destruction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: involves: DBA/1J

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Spta1ihj/Spta1ihj
Genetic Background: involves: HRS/J * LAH

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: either: (B6.C3-Spta1sph x WB.C3-Spta1sph)F1 or (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

Allelic Composition: Spta1sph-3J/Spta1sph-3J
Genetic Background: NOD.Cg-H2b Spta1sph-3J

Allelic Composition: Spta1sph-4J/Spta1sph-4J
Genetic Background: C57BL/6J-Spta1sph-4J/Llp

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: involves: DBA/1J

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0001656 focal hepatic necrosis "a localized area of pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0001862 interstitial pneumonia "disorder of the lower respiratory tract, primarily affecting the alveolar wall, but may also involve the small airways and blood vessels of the lung parencyma; this is usually inflammatory in nature" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Spta1ihj/Spta1ihj
Genetic Background: involves: HRS/J * LAH

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: involves: DBA/1J

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rettm9(RET)Jmi/Rettm9(RET)Jmi
Genetic Background: involves: 129X1/SvJ * 129S1/Sv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: involves: DBA/1J

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkacatm3Gsm/Prkacatm3Gsm
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: involves: DBA/1J

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

 MP:0002424 abnormal reticulocyte morphology/development "anomalous structure, formation, or numbers of immature erthrocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: involves: DBA/1J

Allelic Composition: Spta1sph-2J/Spta1sph-2J
Genetic Background: C3HeB/FeJ-Spta1sph-2J

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: involves: DBA/1J

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Spta1sph-Dem/Spta1sph-Dem
Genetic Background: CcS3/Dem-Spta1sph-Dem

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: (WB.Cg-Spta1sph-2Bc/Brk x B6.Cg-Spta1sph-2Bc/Brk)F1

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

Allelic Composition: Spta1sph-3J/Spta1sph-3J
Genetic Background: NOD.Cg-H2b Spta1sph-3J

Allelic Composition: Spta1sph-4J/Spta1sph-4J
Genetic Background: C57BL/6J-Spta1sph-4J/Llp

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

Allelic Composition: Spta1sph-4J/Spta1sph-4J
Genetic Background: C57BL/6J-Spta1sph-4J/Llp

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: involves: DBA/1J

 MP:0002594 low mean erythrocyte count "less than average numbers of red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Spta1ihj/Spta1ihj
Genetic Background: involves: HRS/J * LAH

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: either: (B6.C3-Spta1sph x WB.C3-Spta1sph)F1 or (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

Allelic Composition: Spta1sph-3J/Spta1sph-3J
Genetic Background: NOD.Cg-H2b Spta1sph-3J

Allelic Composition: Spta1sph-4J/Spta1sph-4J
Genetic Background: C57BL/6J-Spta1sph-4J/Llp

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0002641 anisopoikilocytosis "presence in blood of RBCs of abnormal shapes and sizes" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

Allelic Composition: Spta1sph-3J/Spta1sph-3J
Genetic Background: NOD.Cg-H2b Spta1sph-3J

Allelic Composition: Spta1sph-4J/Spta1sph-4J
Genetic Background: C57BL/6J-Spta1sph-4J/Llp

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Spta1ihj/Spta1ihj
Genetic Background: involves: HRS/J * LAH

Allelic Composition: Spta1sph-3J/Spta1sph-3J
Genetic Background: NOD.Cg-H2b Spta1sph-3J

Allelic Composition: Spta1sph-4J/Spta1sph-4J
Genetic Background: C57BL/6J-Spta1sph-4J/Llp

 MP:0002643 poikilocytosis "blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Spta1ihj/Spta1ihj
Genetic Background: involves: HRS/J * LAH

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

Allelic Composition: Spta1sph-3J/Spta1sph-3J
Genetic Background: NOD.Cg-H2b Spta1sph-3J

Allelic Composition: Spta1sph-4J/Spta1sph-4J
Genetic Background: C57BL/6J-Spta1sph-4J/Llp

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0002704 tubular nephritis "inflammation of the renal tubules" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0002810 microcytic anemia "anemia in which the circulating erythrocyte corpuscular volume is smaller than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: involves: DBA/1J

 MP:0002812 spherocytosis "the presence of sphere-shaped erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Spta1ihj/Spta1ihj
Genetic Background: involves: HRS/J * LAH

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: either: (B6.C3-Spta1sph x WB.C3-Spta1sph)F1 or (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

Allelic Composition: Spta1sph-3J/Spta1sph-3J
Genetic Background: NOD.Cg-H2b Spta1sph-3J

Allelic Composition: Spta1sph-4J/Spta1sph-4J
Genetic Background: C57BL/6J-Spta1sph-4J/Llp

 MP:0002813 microcytosis "the presence of unusually small erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: involves: DBA/1J

Allelic Composition: Spta1ihj/Spta1ihj
Genetic Background: involves: HRS/J * LAH

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: either: (B6.C3-Spta1sph x WB.C3-Spta1sph)F1 or (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

Allelic Composition: Spta1sph-Dem/Spta1sph-Dem
Genetic Background: CcS3/Dem-Spta1sph-Dem

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: (WB.Cg-Spta1sph-2Bc/Brk x B6.Cg-Spta1sph-2Bc/Brk)F1

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0002830 gallstones "caliculi in the gallbladder or a bile duct; chemical composition of cholesterol, calcium carbonate or calcium bilirubinate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: involves: DBA/1J

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

Allelic Composition: Spta1sph-3J/Spta1sph-3J
Genetic Background: NOD.Cg-H2b Spta1sph-3J

Allelic Composition: Spta1sph-4J/Spta1sph-4J
Genetic Background: C57BL/6J-Spta1sph-4J/Llp

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Spta1sph-3J/Spta1sph-3J
Genetic Background: NOD.Cg-H2b Spta1sph-3J

Allelic Composition: Spta1sph-4J/Spta1sph-4J
Genetic Background: C57BL/6J-Spta1sph-4J/Llp

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
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Allelic Composition: Spta1sph-Dem/Spta1sph-Dem
Genetic Background: CcS3/Dem-Spta1sph-Dem

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: either: (B6.C3-Spta1sph x WB.C3-Spta1sph)F1 or (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0003656 abnormal erythrocyte physiology "functional anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: either: (B6.C3-Spta1sph x WB.C3-Spta1sph)F1 or (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Spta1ihj/Spta1ihj
Genetic Background: involves: HRS/J * LAH

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Spta1ihj/Spta1ihj
Genetic Background: involves: HRS/J * LAH

 MP:0003946 renal necrosis "pathological cell death in the kidney, usually due to irreversible damage" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Spta1sph-Dem/Spta1sph-Dem
Genetic Background: CcS3/Dem-Spta1sph-Dem

 MP:0004154 renal tubular necrosis "pathological cell death in the proximal and/or distal renal tubules, usually due to irreversible damage " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spta1sph-3J/Spta1sph-3J
Genetic Background: NOD.Cg-H2b Spta1sph-3J

Allelic Composition: Spta1sph-4J/Spta1sph-4J
Genetic Background: C57BL/6J-Spta1sph-4J/Llp

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph/Spta1sph
Genetic Background: either: (B6.C3-Spta1sph x WB.C3-Spta1sph)F1 or (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

Allelic Composition: Spta1sph-Dem/Spta1sph-Dem
Genetic Background: CcS3/Dem-Spta1sph-Dem

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

 MP:0005096 erythroblastosis "presence of erythroblasts in great number in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: involves: DBA/1J

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

 MP:0005097 polychromatophilia "condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
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Allelic Composition: Spta1ihj/Spta1ihj
Genetic Background: involves: HRS/J * LAH

Allelic Composition: Spta1sph-3J/Spta1sph-3J
Genetic Background: NOD.Cg-H2b Spta1sph-3J

Allelic Composition: Spta1sph-4J/Spta1sph-4J
Genetic Background: C57BL/6J-Spta1sph-4J/Llp

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Spta1ihj/Spta1ihj
Genetic Background: involves: HRS/J * LAH

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

Allelic Composition: Spta1sph-3J/Spta1sph-3J
Genetic Background: NOD.Cg-H2b Spta1sph-3J

Allelic Composition: Spta1sph-4J/Spta1sph-4J
Genetic Background: C57BL/6J-Spta1sph-4J/Llp

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

 MP:0005639 hemosiderosis "condition in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the reticuloendothelial system, without demonstrable tissue damage" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
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Allelic Composition: Spta1sph-3J/Spta1sph-3J
Genetic Background: NOD.Cg-H2b Spta1sph-3J

Allelic Composition: Spta1sph-4J/Spta1sph-4J
Genetic Background: C57BL/6J-Spta1sph-4J/Llp

 MP:0006050 pulmonary fibrosis "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

 MP:0006085 myocardial necrosis "pathological cell death of the cardiac muscle cells, usually due to irreversible damage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92722]
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Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

 MP:0008388 hypochromic microcytic anemia "hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, where the erythrocyte corpuscular volume is smaller than normal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: involves: DBA/1J

 MP:0008807 increased liver iron level "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Spta1sph-3J/Spta1sph-3J
Genetic Background: NOD.Cg-H2b Spta1sph-3J

Allelic Composition: Spta1sph-4J/Spta1sph-4J
Genetic Background: C57BL/6J-Spta1sph-4J/Llp

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0008808 decreased spleen iron level "reduction in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Spta1sph-3J/Spta1sph-3J
Genetic Background: NOD.Cg-H2b Spta1sph-3J

 MP:0008810 increased circulating iron level "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Spta1sph-3J/Spta1sph-3J
Genetic Background: NOD.Cg-H2b Spta1sph-3J

Allelic Composition: Spta1sph-4J/Spta1sph-4J
Genetic Background: C57BL/6J-Spta1sph-4J/Llp

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

 MP:0008828 abnormal lymph node cell ratio "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

 MP:0008956 decreased cellular hemoglobin content "decrease in the mean of the red blood cell hemoglobin concentration (RBC CH) histogram, which represents the distribution of red blood cells by the amount of hemoglobin present in each individual cell independent of cell volume" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0009547 elliptocytosis "hematologic disorder in which an abnormally large number of erythrocytes are elliptical rather than the typical biconcave, disc shape" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Spta1sph-Dem/Spta1sph-Dem
Genetic Background: CcS3/Dem-Spta1sph-Dem

Allelic Composition: Spta1sph-3J/Spta1sph-3J
Genetic Background: NOD.Cg-H2b Spta1sph-3J

 MP:0009568 abnormal red blood cell deformability "a measure (DImax) related to cell surface area, of the changeability of the membrane of circulating oxygen transporting cells as a function of physiologically relevant osmolality at a constant applied shear stress" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: (WB.Cg-Spta1sph-2Bc/Brk x B6.Cg-Spta1sph-2Bc/Brk)F1

Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

 MP:0010019 liver vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010035 increased erythrocyte clearance "increased elimination of aging erythrocytes from the body by autoregulatory mechanisms, often expressed as half-life" [GO:0034102, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

Allelic Composition: Spta1sph-ha/Spta1+
Genetic Background: involves: DBA/1J

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0010163 hemolysis "destruction of erythrocytes such that hemoglobin is released from the cells; may occur by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0010375 increased kidney iron level "increase in the amount of iron present in the renal tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Spta1sph-3J/Spta1sph-3J
Genetic Background: NOD.Cg-H2b Spta1sph-3J

Allelic Composition: Spta1sph-4J/Spta1sph-4J
Genetic Background: C57BL/6J-Spta1sph-4J/Llp

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0010903 abnormal pulmonary alveolus wall morphology 
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

 MP:0010922 alveolitis "inflammation of the small sac-like dilations of the distal airspace of the lung; acute pulmonary alveolitis involves exudate into the pulmonary alveoli and impaired gas exchange" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: involves: DBA/1J

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: B6.C3-Spta1sph/BrkJ

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: B6.C3-Spta1sph/BrkJ

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: involves: DBA/1J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

 MP:0011188 increased erythrocyte protoporphyrin level "an accumulation of the intermediates of heme biosynthesis in red blood cells" [MGI:csmith]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

Allelic Composition: Spta1sph-ha/Spta1+
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: either: (B6.C3-Spta1sph x WB.C3-Spta1sph)F1 or (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

Allelic Composition: Spta1sph/Spta1+
Genetic Background: either: (B6.C3-Spta1sph x WB.C3-Spta1sph)F1 or (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0020409 abnormal cardiac thrombosis "any anomaly in the formation or presence of thrombi in the heart" [PMID:15870284]
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Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: (WB.Cg-Spta1sph-2Bc/Brk x B6.Cg-Spta1sph-2Bc/Brk)F1

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction / complex
 ENSMUSG00000032826 Ank2 / Q8C8R3 / Ankyrin-2 / Q01484*  / reaction / complex
 ENSMUSG00000057738 P16546 / Sptan1 / Spectrin alpha chain, non-erythrocytic 1 / Q13813* / spectrin alpha, non-erythrocytic 1*  / complex
 ENSMUSG00000031543 Ank1 / Q02357 / Ankyrin-1 / P16157*  / complex / reaction
 ENSMUSG00000020315 Q62261 / Sptbn1 / Spectrin beta chain, non-erythrocytic 1 / Q01082* / spectrin beta, non-erythrocytic 1*  / complex
 ENSMUSG00000011751 Sptbn4 / spectrin beta, non-erythrocytic 4 / Q9H254*  / complex
 ENSMUSG00000021061 Sptb / spectrin beta, erythrocytic / P11277*  / complex
 ENSMUSG00000026532 Spta1 / P08032 / Spectrin alpha chain, erythrocytic 1 / P02549* / spectrin alpha, erythrocytic 1*  / complex
 ENSMUSG00000067889 Sptbn2 / spectrin beta, non-erythrocytic 2 / O15020*  / complex
 ENSMUSG00000027303 Ptpra / P18052 / protein tyrosine phosphatase, receptor type, A / P18433*  / complex
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / complex
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / complex






 

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