ENSMUSG00000015143


Mus musculus

Features
Gene ID: ENSMUSG00000015143
  
Biological name :Actn1
  
Synonyms : Actn1 / Mus musculus actinin, alpha 1 (Actn1), transcript variant 2, mRNA. / Q7TPR4
  
Possible biological names infered from orthology : actinin alpha 1 / P12814
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: C3
Gene start: 80167547
Gene end: 80260371
  
Corresponding Affymetrix probe sets: 10401244 (MoGene1.0st)   1427385_s_at (Mouse Genome 430 2.0 Array)   1428585_at (Mouse Genome 430 2.0 Array)   1452415_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021554
Ensembl peptide - ENSMUSP00000127176
NCBI entrez gene - 109711     See in Manteia.
MGI - MGI:2137706
RefSeq - XM_006515390
RefSeq - NM_001346669
RefSeq - NM_134156
RefSeq - XM_006515386
RefSeq - XM_006515387
RefSeq - XM_006515388
RefSeq - XM_006515389
RefSeq - XM_006515384
RefSeq - XM_006515385
RefSeq Peptide - NP_001333598
RefSeq Peptide - NP_598917
swissprot - Q7TPR4
swissprot - A1BN54
Ensembl - ENSMUSG00000015143
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 actn1ENSDARG00000007219Danio rerio
 ACTN1ENSGALG00000042458Gallus gallus
 ACTN1ENSG00000072110Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Actn4 / P57780 / Alpha-actinin-4 / O43707* / actinin alpha 4*ENSMUSG0000005480886
Actn2 / Q9JI91 / Alpha-actinin-2 / P35609* / actinin alpha 2*ENSMUSG0000005237480
Actn3 / O88990 / Alpha-actinin-3 / Q08043* / actinin alpha 3 (gene/pseudogene)*ENSMUSG0000000645778
Q62261 / Sptbn1 / Spectrin beta chain, non-erythrocytic 1 / Q01082* / spectrin beta, non-erythrocytic 1*ENSMUSG0000002031531
Sptb / spectrin beta, erythrocytic / P11277*ENSMUSG0000002106130
Sptbn2 / spectrin beta, non-erythrocytic 2 / O15020*ENSMUSG0000006788930
Sptbn4 / spectrin beta, non-erythrocytic 4 / Q9H254*ENSMUSG0000001175129
P16546 / Sptan1 / Spectrin alpha chain, non-erythrocytic 1 / Q13813* / spectrin alpha, non-erythrocytic 1*ENSMUSG0000005773820
Spta1 / P08032 / Spectrin alpha chain, erythrocytic 1 / P02549* / spectrin alpha, erythrocytic 1*ENSMUSG0000002653217


Protein motifs (from Interpro)
Interpro ID Name
 IPR001589  Actinin-type actin-binding domain, conserved site
 IPR001715  Calponin homology domain
 IPR002017  Spectrin repeat
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR014837  EF-hand, Ca insensitive
 IPR018159  Spectrin/alpha-actinin
 IPR018247  EF-Hand 1, calcium-binding site
 IPR026921  Alpha-actinin 1
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0030220 platelet formation IEA
 biological_processGO:0030865 cortical cytoskeleton organization TAS
 biological_processGO:0036344 platelet morphogenesis IEA
 biological_processGO:0048041 focal adhesion assembly IEA
 biological_processGO:0051017 actin filament bundle assembly IEA
 biological_processGO:0051271 negative regulation of cellular component movement IEA
 biological_processGO:0051639 actin filament network formation IEA
 biological_processGO:0051764 actin crosslink formation IEA
 biological_processGO:1903506 regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0001725 stress fiber IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005916 fascia adherens IDA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030017 sarcomere IDA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030141 secretory granule NAS
 cellular_componentGO:0030863 cortical cytoskeleton TAS
 cellular_componentGO:0032127 dense core granule membrane TAS
 cellular_componentGO:0042995 cell projection ISO
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017166 vinculin binding IEA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022438 Parvb / Q9ES46 / parvin, beta / Q9HBI1*  / reaction / complex






 

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