ENSMUSG00000052374


Mus musculus

Features
Gene ID: ENSMUSG00000052374
  
Biological name :Actn2
  
Synonyms : Actn2 / Alpha-actinin-2 / Q9JI91
  
Possible biological names infered from orthology : actinin alpha 2 / P35609
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A1
Gene start: 12269426
Gene end: 12340760
  
Corresponding Affymetrix probe sets: 10407742 (MoGene1.0st)   1448327_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152121
Ensembl peptide - ENSMUSP00000067708
Ensembl peptide - ENSMUSP00000129609
NCBI entrez gene - 11472     See in Manteia.
MGI - MGI:109192
RefSeq - NM_033268
RefSeq - XM_011244263
RefSeq Peptide - NP_150371
swissprot - A0A1Y7VMW4
swissprot - Q9JI91
Ensembl - ENSMUSG00000052374
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 actn2bENSDARG00000071090Danio rerio
 ACTN2ENSGALG00000014463Gallus gallus
 ACTN2ENSG00000077522Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Actn3 / O88990 / Alpha-actinin-3 / Q08043* / actinin alpha 3 (gene/pseudogene)*ENSMUSG0000000645780
Actn1 / Q7TPR4 / Mus musculus actinin, alpha 1 (Actn1), transcript variant 2, mRNA. / P12814* / actinin alpha 1*ENSMUSG0000001514379
Actn4 / P57780 / Alpha-actinin-4 / O43707* / actinin alpha 4*ENSMUSG0000005480877
Sptbn2 / spectrin beta, non-erythrocytic 2 / O15020*ENSMUSG0000006788929
Q62261 / Sptbn1 / Spectrin beta chain, non-erythrocytic 1 / Q01082* / spectrin beta, non-erythrocytic 1*ENSMUSG0000002031529
Sptbn4 / spectrin beta, non-erythrocytic 4 / Q9H254*ENSMUSG0000001175128
Sptb / spectrin beta, erythrocytic / P11277*ENSMUSG0000002106128
P16546 / Sptan1 / Spectrin alpha chain, non-erythrocytic 1 / Q13813* / spectrin alpha, non-erythrocytic 1*ENSMUSG0000005773819
Spta1 / P08032 / Spectrin alpha chain, erythrocytic 1 / P02549* / spectrin alpha, erythrocytic 1*ENSMUSG0000002653216


Protein motifs (from Interpro)
Interpro ID Name
 IPR001589  Actinin-type actin-binding domain, conserved site
 IPR001715  Calponin homology domain
 IPR002017  Spectrin repeat
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR014837  EF-hand, Ca insensitive
 IPR018159  Spectrin/alpha-actinin
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006936 muscle contraction IDA
 biological_processGO:0030035 microspike assembly ISO
 biological_processGO:0042391 regulation of membrane potential ISO
 biological_processGO:0043267 negative regulation of potassium ion transport ISO
 biological_processGO:0043268 positive regulation of potassium ion transport ISO
 biological_processGO:0045214 sarcomere organization ISO
 biological_processGO:0048041 focal adhesion assembly ISO
 biological_processGO:0051289 protein homotetramerization ISO
 biological_processGO:0051695 actin filament uncapping ISO
 biological_processGO:0055013 cardiac muscle cell development IMP
 biological_processGO:0072659 protein localization to plasma membrane IMP
 biological_processGO:0086097 phospholipase C-activating angiotensin-activated signaling pathway ISO
 biological_processGO:1901017 negative regulation of potassium ion transmembrane transporter activity ISO
 biological_processGO:1901018 positive regulation of potassium ion transmembrane transporter activity ISO
 biological_processGO:1903506 regulation of nucleic acid-templated transcription IEA
 biological_processGO:2000009 negative regulation of protein localization to cell surface ISO
 biological_processGO:2001137 positive regulation of endocytic recycling IMP
 biological_processGO:2001259 positive regulation of cation channel activity IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005865 striated muscle thin filament TAS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005925 focal adhesion ISO
 cellular_componentGO:0030017 sarcomere IDA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0030175 filopodium ISO
 cellular_componentGO:0030864 cortical actin cytoskeleton IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding ISO
 molecular_functionGO:0008092 cytoskeletal protein binding IDA
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0030274 LIM domain binding IPI
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IDA
 molecular_functionGO:0030375 thyroid hormone receptor coactivator activity IDA
 molecular_functionGO:0030674 protein binding, bridging TAS
 molecular_functionGO:0031432 titin binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity TAS
 molecular_functionGO:0044325 ion channel binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046983 protein dimerization activity ISO
 molecular_functionGO:0051015 actin filament binding TAS
 molecular_functionGO:0051373 FATZ binding ISO
 molecular_functionGO:0070080 titin Z domain binding ISO


Pathways (from Reactome)
Pathway description
Platelet degranulation
Striated Muscle Contraction
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025892 Gria4 / Q9Z2W8 / glutamate receptor, ionotropic, AMPA4 (alpha 4) / P48058* / glutamate ionotropic receptor AMPA type subunit 4*  / reaction
 ENSMUSG00000022055 Nefl / P08551 / Neurofilament light polypeptide / P07196* / neurofilament light*  / complex
 ENSMUSG00000020524 Gria1 / P23818 / Glutamate receptor 1 / P42261* / glutamate ionotropic receptor AMPA type subunit 1*  / reaction
 ENSMUSG00000024617 Camk2a / P11798 / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / reaction / complex
 ENSMUSG00000030209 Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*  / complex
 ENSMUSG00000002771 Grin2d / Q03391 / Glutamate receptor ionotropic, NMDA 2D / O15399* / glutamate ionotropic receptor NMDA type subunit 2D*  / complex
 ENSMUSG00000059003 Grin2a / P35436 / Glutamate receptor ionotropic, NMDA 2A / Q12879* / glutamate ionotropic receptor NMDA type subunit 2A*  / complex
 ENSMUSG00000026959 Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*  / complex
 ENSMUSG00000020734 Grin2c / Q01098 / Glutamate receptor ionotropic, NMDA 2C / Q14957* / glutamate ionotropic receptor NMDA type subunit 2C*  / complex
 ENSMUSG00000021820 Camk2g / Q923T9 / Calcium/calmodulin-dependent protein kinase type II subunit gamma / Q13555* / calcium/calmodulin dependent protein kinase II gamma*  / complex / reaction
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / complex
 ENSMUSG00000057897 Camk2b / P28652 / Calcium/calmodulin-dependent protein kinase type II subunit beta / Q13554* / calcium/calmodulin dependent protein kinase II beta*  / complex / reaction
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / complex / reaction
 ENSMUSG00000032356 P27671 / Rasgrf1 / RAS protein-specific guanine nucleotide-releasing factor 1 / Q13972*  / reaction / complex
 ENSMUSG00000053819 Camk2d / Q6PHZ2 / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q13557* / calcium/calmodulin dependent protein kinase II delta*  / complex / reaction
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSMUSG00000052374 Actn2 / Q9JI91 / Alpha-actinin-2 / P35609* / actinin alpha 2*  / complex
 ENSMUSG00000001986 Gria3 / Q9Z2W9 / Mus musculus glutamate receptor, ionotropic, AMPA3 (alpha 3) (Gria3), transcript variant 5, mRNA. / P42263* / glutamate ionotropic receptor AMPA type subunit 3*  / reaction






 

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