ENSGALG00000014463


Gallus gallus

Features
Gene ID: ENSGALG00000014463
  
Biological name :ACTN2
  
Synonyms : ACTN2 / Alpha-actinin-2 / P20111
  
Possible biological names infered from orthology : actinin alpha 2 / P35609 / Q9JI91
  
Species: Gallus gallus
  
Chr. number: 3
Strand: -1
Band:
Gene start: 37757315
Gene end: 37822442
  
Corresponding Affymetrix probe sets: Gga.18031.1.S1_at (Chicken Array)   Gga.4843.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000023309
Ensembl peptide - ENSGALP00000064678
Ensembl peptide - ENSGALP00000058457
Ensembl peptide - ENSGALP00000054549
NCBI entrez gene - 396263     See in Manteia.
RefSeq - NM_205323
RefSeq Peptide - NP_990654
swissprot - A0A1D5PZP3
swissprot - A0A1D5PNV5
swissprot - A0A1L1S0L2
swissprot - P20111
swissprot - R9PXQ0
Ensembl - ENSGALG00000014463
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 actn2bENSDARG00000071090Danio rerio
 ACTN2ENSG00000077522Homo sapiens
 Actn2ENSMUSG00000052374Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACTN1 / P05094 / Alpha-actinin-1 / P12814* / Q7TPR4* / actinin alpha 1* / Mus musculus actinin, alpha 1 (Actn1), transcript variant 2, mRNA.*ENSGALG0000004245880
SPTBN5 / spectrin beta, non-erythrocytic 5 / Q9NRC6*ENSGALG0000000894031
SPTBN1 / spectrin beta, non-erythrocytic 1 / Q01082* / Q62261* / Spectrin beta chain, non-erythrocytic 1 *ENSGALG0000002951229
SPTB / spectrin beta, erythrocytic / P11277*ENSGALG0000003680527
SPTAN1 / spectrin alpha chain, non-erythrocytic 1 / P16546* / Q13813* / spectrin alpha, non-erythrocytic 1*ENSGALG0000000471919


Protein motifs (from Interpro)
Interpro ID Name
 IPR001589  Actinin-type actin-binding domain, conserved site
 IPR001715  Calponin homology domain
 IPR002017  Spectrin repeat
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR014837  EF-hand, Ca insensitive
 IPR018159  Spectrin/alpha-actinin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006936 muscle contraction IEA
 biological_processGO:0030035 microspike assembly IDA
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0043267 negative regulation of potassium ion transport IEA
 biological_processGO:0043268 positive regulation of potassium ion transport IEA
 biological_processGO:0045214 sarcomere organization IEA
 biological_processGO:0048041 focal adhesion assembly IEA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0051695 actin filament uncapping IEA
 biological_processGO:0055013 cardiac muscle cell development IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0086097 phospholipase C-activating angiotensin-activated signaling pathway IEA
 biological_processGO:1901017 negative regulation of potassium ion transmembrane transporter activity IEA
 biological_processGO:1901018 positive regulation of potassium ion transmembrane transporter activity IEA
 biological_processGO:1903506 regulation of nucleic acid-templated transcription IEA
 biological_processGO:2000009 negative regulation of protein localization to cell surface IEA
 biological_processGO:2001137 positive regulation of endocytic recycling IEA
 biological_processGO:2001259 positive regulation of cation channel activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0030017 sarcomere IEA
 cellular_componentGO:0030018 Z disc ISS
 cellular_componentGO:0030175 filopodium IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030274 LIM domain binding IEA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IEA
 molecular_functionGO:0030375 thyroid hormone receptor coactivator activity IEA
 molecular_functionGO:0031432 titin binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0051015 actin filament binding IEA
 molecular_functionGO:0051373 FATZ binding IEA
 molecular_functionGO:0070080 titin Z domain binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Striated Muscle Contraction
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000314 NEFL / neurofilament light / P07196* / P08551* / Neurofilament light polypeptide *  / complex
 ENSGALG00000004083 GRIA1 / glutamate ionotropic receptor AMPA type subunit 1 / P23818* / P42261* / Glutamate receptor 1 *  / reaction
 ENSGALG00000005621 CAMK2A / calcium/calmodulin-dependent protein kinase type II subunit alpha / P11798* / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / reaction / complex
 ENSGALG00000007278 GRIN2A / glutamate ionotropic receptor NMDA type subunit 2A / P35436* / Q12879* / Glutamate receptor ionotropic, NMDA 2A *  / complex
 ENSGALG00000015598 RASGRF2 / Ras protein specific guanine nucleotide releasing factor 2 / O14827* / ras-specific guanine nucleotide-releasing factor 2 *  / complex / reaction
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSGALG00000008898 GRIN1 / glutamate ionotropic receptor NMDA type subunit 1 / P35438* / Q05586* / Glutamate receptor ionotropic, NMDA 1 *  / complex
 ENSGALG00000010023 CALM2 / P62149 / Calmodulin / Calm3* / CALM1* / P0DP23* / P0DP26* / P0DP27* / P0DP28* / calmodulin 1*  / reaction / complex
 ENSGALG00000027415 GRIN2C / glutamate ionotropic receptor NMDA type subunit 2C / Q01098* / Q14957* / Glutamate receptor ionotropic, NMDA 2C *  / complex
 ENSGALG00000014463 ACTN2 / P20111 / Alpha-actinin-2 / P35609* / Q9JI91* / actinin alpha 2*  / complex
 ENSGALG00000038995 GRIA4 / glutamate receptor 4 isoform 1 precursor / P48058* / Q9Z2W8* / glutamate receptor, ionotropic, AMPA4 (alpha 4)* / glutamate ionotropic receptor AMPA type subunit 4*  / reaction
 ENSGALG00000040724 AKAP9 / A-kinase anchoring protein 9 / Q99996*  / complex






 

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