ENSGALG00000000314


Gallus gallus

Features
Gene ID: ENSGALG00000000314
  
Biological name :NEFL
  
Synonyms : NEFL / neurofilament light
  
Possible biological names infered from orthology : Neurofilament light polypeptide / P07196 / P08551
  
Species: Gallus gallus
  
Chr. number: 22
Strand: 1
Band:
Gene start: 952291
Gene end: 957139
  
Corresponding Affymetrix probe sets: GgaAffx.25567.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000000419
Ensembl peptide - ENSGALP00000063512
Ensembl peptide - ENSGALP00000062579
NCBI entrez gene - 419528     See in Manteia.
RefSeq - XM_417679
swissprot - E1C5R3
swissprot - A0A1L1RXE3
swissprot - A0A1L1RUS3
Ensembl - ENSGALG00000000314
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 neflaENSDARG00000057568Danio rerio
 neflbENSDARG00000012426Danio rerio
 NEFLENSG00000277586Homo sapiens
 NeflENSMUSG00000022055Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NEFM / neurofilament medium polypeptide / P07197* / neurofilament medium*ENSGALG0000000031744
VIM / vimentin / P08670* / P20152*ENSGALG0000000867736
DES / desmin / P17661* / P31001*ENSGALG0000001130635
GFAP / glial fibrillary acidic protein / P03995* / P14136*ENSGALG0000000090933
NEFH / neurofilament heavy / P12036* / P19246* / Neurofilament heavy polypeptide *ENSGALG0000000808533
LMNB2 / lamin-B2 / P21619* / Q03252*ENSGALG0000000047024
LMNB1 / lamin-B1 / P14733* / P20700*ENSGALG0000001469223
LMNA* / P02545* / P48678* / lamin A/C* / Prelamin-A/C Lamin-A/C*ENSGALG0000000608323


Protein motifs (from Interpro)
Interpro ID Name
 IPR001664  Intermediate filament protein
 IPR002957  Keratin, type I
 IPR006821  Intermediate filament head, DNA-binding domain
 IPR018039  Intermediate filament protein, conserved site
 IPR027692  Neurofilament light polypeptide


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0008089 anterograde axonal transport IEA
 biological_processGO:0008090 retrograde axonal transport IEA
 biological_processGO:0014012 peripheral nervous system axon regeneration IEA
 biological_processGO:0019896 axonal transport of mitochondrion IEA
 biological_processGO:0031133 regulation of axon diameter IEA
 biological_processGO:0033693 neurofilament bundle assembly IEA
 biological_processGO:0040011 locomotion IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045109 intermediate filament organization IEA
 biological_processGO:0045110 intermediate filament bundle assembly IEA
 biological_processGO:0048812 neuron projection morphogenesis IEA
 biological_processGO:0050772 positive regulation of axonogenesis IEA
 biological_processGO:0050885 neuromuscular process controlling balance IEA
 biological_processGO:0060052 neurofilament cytoskeleton organization IEA
 biological_processGO:0061564 axon development IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005882 intermediate filament IEA
 cellular_componentGO:0005883 neurofilament IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0033596 TSC1-TSC2 complex IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:1904115 axon cytoplasm IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0030674 protein binding, bridging IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000027415 GRIN2C / glutamate ionotropic receptor NMDA type subunit 2C / Q01098* / Q14957* / Glutamate receptor ionotropic, NMDA 2C *  / complex
 ENSGALG00000015598 RASGRF2 / Ras protein specific guanine nucleotide releasing factor 2 / O14827* / ras-specific guanine nucleotide-releasing factor 2 *  / complex / reaction
 ENSGALG00000005621 CAMK2A / calcium/calmodulin-dependent protein kinase type II subunit alpha / P11798* / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / reaction / complex
 ENSGALG00000007278 GRIN2A / glutamate ionotropic receptor NMDA type subunit 2A / P35436* / Q12879* / Glutamate receptor ionotropic, NMDA 2A *  / complex
 ENSGALG00000014463 ACTN2 / P20111 / Alpha-actinin-2 / P35609* / Q9JI91* / actinin alpha 2*  / complex
 ENSGALG00000010023 CALM2 / P62149 / Calmodulin / Calm3* / CALM1* / P0DP23* / P0DP26* / P0DP27* / P0DP28* / calmodulin 1*  / complex / reaction
 ENSGALG00000008898 GRIN1 / glutamate ionotropic receptor NMDA type subunit 1 / P35438* / Q05586* / Glutamate receptor ionotropic, NMDA 1 *  / complex
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSGALG00000004083 GRIA1 / glutamate ionotropic receptor AMPA type subunit 1 / P23818* / P42261* / Glutamate receptor 1 *  / reaction
 ENSGALG00000038995 GRIA4 / glutamate receptor 4 isoform 1 precursor / P48058* / Q9Z2W8* / glutamate receptor, ionotropic, AMPA4 (alpha 4)* / glutamate ionotropic receptor AMPA type subunit 4*  / reaction
 ENSGALG00000040724 AKAP9 / A-kinase anchoring protein 9 / Q99996*  / complex






 

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