ENSGALG00000029260


Gallus gallus

Features
Gene ID: ENSGALG00000029260
  
Biological name :H-RAS
  
Synonyms : GTPase HRas GTPase HRas, N-terminally processed / H-RAS / P08642
  
Possible biological names infered from orthology : HRAS / HRas proto-oncogene, GTPase / P01112 / Q61411
  
Species: Gallus gallus
  
Chr. number: 5
Strand: 1
Band:
Gene start: 16012671
Gene end: 16077001
  
Corresponding Affymetrix probe sets: Gga.3849.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000051306
NCBI entrez gene - 107053420     See in Manteia.
RefSeq - XM_015286754
swissprot - F5ANT1
swissprot - P08642
Ensembl - ENSGALG00000029260
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hrasaENSDARG00000098497Danio rerio
 hrasbENSDARG00000005651Danio rerio
 HRASENSG00000174775Homo sapiens
 HrasENSMUSG00000025499Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*ENSGALG00000034526100
KRAS / KRAS proto-oncogene, GTPase / P01116* / P32883* / GTPase KRas GTPase KRas, N-terminally processed*ENSGALG0000003094387
NRAS / GTPase NRas precursor / P01111* / neuroblastoma ras oncogene* / NRAS proto-oncogene, GTPase*ENSGALG0000002669285
RRAS2 / RAS related 2 / P62070* / P62071* / Ras-related protein R-Ras2 *ENSGALG0000000599857
MRAS / muscle RAS oncogene homolog / O08989* / O14807* / muscle and microspikes RAS*ENSGALG0000001159252
RALA / RAS like proto-oncogene A / P11233* / P63321* / Ras-related protein Ral-A *ENSGALG0000003189349
RALB / RAS like proto-oncogene B / P11234* / Q9JIW9* / Ras-related protein Ral-B *ENSGALG0000002649348
RERG / RAS like estrogen regulated growth inhibitor / Q8R367* / Q96A58* / Ras-related and estrogen-regulated growth inhibitor *ENSGALG0000002818637
ENSGALG0000002777832
RASL11A / RAS like family 11 member A / Q6IMB1* / Q6T310* / Ras-like protein family member 11A *ENSGALG0000001709930
GEM / GTP-binding protein GEM / P55040* / P55041* / GTP binding protein overexpressed in skeletal muscle*ENSGALG0000003250629
RASL12 / RAS like family 12 / Q08AT1* / Q9NYN1* / Ras-like protein family member 12 *ENSGALG0000000734928
ENSGALG0000000771028
REM1 / RRAD and GEM like GTPase 1 / O35929* / O75628* / GTP-binding protein REM 1 *ENSGALG0000004560228
RASL11B / RAS like family 11 member B / Q922H7* / Q9BPW5* / Ras-like protein family member 11B *ENSGALG0000001394827
RERGL / RERG like / Q9H628* / RERG/RAS-like*ENSGALG0000001311227
RRAD / GTP-binding protein RAD / P55042* / Ras-related associated with diabetes* / RRAD, Ras related glycolysis inhibitor and calcium channel regulator*ENSGALG0000000514026


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR020849  Small GTPase superfamily, Ras-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000314 NEFL / neurofilament light / P07196* / P08551* / Neurofilament light polypeptide *  / reaction
 ENSGALG00000000681 PAK1 / p21 (RAC1) activated kinase 1 / Q13153* / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA.*  / reaction
 ENSGALG00000000949 HBEGF / Q9W7C5 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q06186* / Q99075* / heparin binding EGF like growth factor*  / reaction
 ENSGALG00000015708 FGFR3 / fibroblast growth factor receptor 3 / P22607* / Mus musculus fibroblast growth factor receptor 3 (Fgfr3), transcript variant 6, mRNA.*  / reaction
 ENSGALG00000004741 EPHB2 / EPH receptor B2 / P29323* / P54763* / Ephrin type-B receptor 2 *  / complex / reaction
 ENSGALG00000002952 NRG4 / neuregulin 4 / Q8WWG1* / Q9WTX4* / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4*  / reaction
 ENSGALG00000003412 RGL4* / RGL2* / Q12967* / Q61193* / RALGDS* / Q8IZJ4* / O15211* / Q03385* / AL162417.1* / ral guanine nucleotide dissociation stimulator* / ral guanine nucleotide dissociation stimulator li...  / reaction / complex
 ENSGALG00000005621 CAMK2A / calcium/calmodulin-dependent protein kinase type II subunit alpha / P11798* / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / reaction
 ENSGALG00000007278 GRIN2A / glutamate ionotropic receptor NMDA type subunit 2A / P35436* / Q12879* / Glutamate receptor ionotropic, NMDA 2A *  / reaction
 ENSGALG00000008058 PAK3 / p21 (RAC1) activated kinase 3 / O75914* / Q61036* / Serine/threonine-protein kinase PAK 3 *  / reaction
 ENSGALG00000007403 PEBP1 / phosphatidylethanolamine binding protein 1 / Pbp2* / P30086* / P70296*  / complex / reaction
 ENSGALG00000006609 EPHB1 / EPH receptor B1 / P54762* / Q8CBF3* / Ephrin type-B receptor 1 *  / complex / reaction
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / reaction
 ENSGALG00000006426 PAK2 / p21 (RAC1) activated kinase 2 / Q13177* / Q8CIN4* / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34*  / reaction
 ENSGALG00000011505 MARK3 / microtubule affinity regulating kinase 3 / P27448* / Q03141* / MAP/microtubule affinity-regulating kinase 3 *  / complex / reaction
 ENSGALG00000004998 RAF1 / P05625 / RAF proto-oncogene serine/threonine-protein kinase / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), t...  / complex / reaction
 ENSGALG00000028543 FGFR4 / fibroblast growth factor receptor 4 / P22455*  / reaction
 ENSGALG00000017068 KL / klotho / O35082* / Q9UEF7* / Klotho Klotho peptide*  / reaction
 ENSGALG00000014463 ACTN2 / P20111 / Alpha-actinin-2 / P35609* / Q9JI91* / actinin alpha 2*  / reaction
 ENSGALG00000010023 CALM2 / P62149 / Calmodulin / Calm3* / CALM1* / P0DP23* / P0DP26* / P0DP27* / P0DP28* / calmodulin 1*  / reaction
 ENSGALG00000009966 FRS2 / fibroblast growth factor receptor substrate 2 / Q8C180* / Q8WU20*  / reaction
 ENSGALG00000015422 NRG1 / pro-neuregulin-1, membrane-bound isoform / Q02297* / neuregulin 1*  / reaction
 ENSGALG00000015598 RASGRF2 / Ras protein specific guanine nucleotide releasing factor 2 / O14827* / ras-specific guanine nucleotide-releasing factor 2 *  / reaction
 ENSGALG00000012865 BRAF / Q04982 / Serine/threonine-protein kinase B-raf / P15056* / P28028* / B-Raf proto-oncogene, serine/threonine kinase*  / reaction / complex
 ENSGALG00000017706 RASA1* / P20936* / RAS p21 protein activator 1*  / complex / reaction
 ENSGALG00000010435 RASGRP3 / RAS guanyl releasing protein 3 / Q8IV61*  / reaction
 ENSGALG00000036883 MET / hepatocyte growth factor receptor precursor / P08581* / MET proto-oncogene, receptor tyrosine kinase*  / reaction
 ENSGALG00000023541 SPHK1 / sphingosine kinase 1 / Q8CI15* / Q9NYA1*  / reaction
 ENSGALG00000027415 GRIN2C / glutamate ionotropic receptor NMDA type subunit 2C / Q01098* / Q14957* / Glutamate receptor ionotropic, NMDA 2C *  / reaction
 ENSGALG00000027791 FGF23 / fibroblast growth factor 23 / Q9EPC2* / Q9GZV9*  / reaction
 ENSGALG00000028608 BTC / probetacellulin precursor / P35070* / Q05928* / betacellulin* / Probetacellulin Betacellulin*  / reaction
 ENSGALG00000003126 ERBB4 / receptor tyrosine-protein kinase erbB-4 / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain*  / reaction
 ENSGALG00000038089 EGFR / epidermal growth factor receptor / P00533* / Q01279*  / reaction
 ENSGALG00000004143 YWHAB / Q5ZLQ6 / 14-3-3 protein beta/alpha / Q9CQV8* / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta* / tyrosine 3-monooxygenase/tryptophan 5-monoox...  / complex / reaction
 ENSGALG00000008898 GRIN1 / glutamate ionotropic receptor NMDA type subunit 1 / P35438* / Q05586* / Glutamate receptor ionotropic, NMDA 1 *  / reaction
 ENSGALG00000028376 FGF19 / fibroblast growth factor 19 / Fgf15* / O95750* / O35622* / Fibroblast growth factor 15 *  / reaction
 ENSGALG00000029175 EFNB2 / ephrin B2 / P52799* / P52800*  / complex / reaction
 ENSGALG00000009495 FGFR2 / P18461 / Fibroblast growth factor receptor 2 / P21802* / fibroblast growth factor receptor 2 isoform 3 *  / reaction
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000001501 MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction
 ENSGALG00000007687 MAP2K1 / mitogen-activated protein kinase kinase 1 / P31938* / Q02750* / Dual specificity mitogen-activated protein kinase kinase 1 *  / complex / reaction
 ENSGALG00000031529 ERBB2 / receptor tyrosine-protein kinase erbB-2 precursor / P04626* / P70424* / erb-b2 receptor tyrosine kinase 2* / Receptor tyrosine-protein kinase erbB-2 *  / reaction
 ENSGALG00000039786 FGFR1 / fibroblast growth factor receptor 1 precursor / P11362* / P16092* / fibroblast growth factor receptor 1*  / reaction
 ENSGALG00000040724 AKAP9 / A-kinase anchoring protein 9 / Q99996*  / reaction
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / reaction
 ENSGALG00000033974 HGF / hepatocyte growth factor / P14210* / Q08048* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / reaction






 

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