ENSGALG00000028543


Gallus gallus

Features
Gene ID: ENSGALG00000028543
  
Biological name :FGFR4
  
Synonyms : FGFR4 / fibroblast growth factor receptor 4
  
Possible biological names infered from orthology : P22455
  
Species: Gallus gallus
  
Chr. number: 13
Strand: -1
Band:
Gene start: 10261730
Gene end: 10269384
  
Corresponding Affymetrix probe sets: Gga.2908.1.S1_at (Chicken Array)   Gga.3907.1.S1_at (Chicken Array)   GgaAffx.23244.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000025286
NCBI entrez gene - 395603     See in Manteia.
RefSeq - XM_015293863
RefSeq - XM_015293864
swissprot - F1NCL8
Ensembl - ENSGALG00000028543
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgfr4ENSDARG00000069105Danio rerio
 FGFR4ENSG00000160867Homo sapiens
 Fgfr4ENSMUSG00000005320Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGFR3 / fibroblast growth factor receptor 3 / P22607* / Mus musculus fibroblast growth factor receptor 3 (Fgfr3), transcript variant 6, mRNA.*ENSGALG0000001570865
FGFR2 / P18461 / Fibroblast growth factor receptor 2 / P21802* / fibroblast growth factor receptor 2 isoform 3 *ENSGALG0000000949562
FGFR1 / fibroblast growth factor receptor 1 precursor / P11362* / P16092* / fibroblast growth factor receptor 1*ENSGALG0000003978660
KDR / vascular endothelial growth factor receptor 2 precursor / P35968* / kinase insert domain receptor*ENSGALG0000001390731
FLT4 / fms related tyrosine kinase 4 / P35916* / P35917* / Vascular endothelial growth factor receptor 3 *ENSGALG0000000580230
ENSGALG0000000764629
FLT1 / vascular endothelial growth factor receptor 1 precursor / P17948* / fms related tyrosine kinase 1*ENSGALG0000001709129
PDGFRA / platelet derived growth factor receptor alpha / P16234* / P26618* / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA.*ENSGALG0000001392928
CSF1R / Gallus gallus colony stimulating factor 1 receptor (CSF1R), mRNA. / P07333* / P09581* / colony stimulating factor 1 receptor* / Macrophage colony-stimulating factor 1 receptor *ENSGALG0000000572527
KIT / Q08156 / Mast/stem cell growth factor receptor Kit / P05532* / P10721* / KIT proto-oncogene receptor tyrosine kinase*ENSGALG0000003863427
PDGFRB / platelet derived growth factor receptor beta / P09619* / platelet-derived growth factor receptor beta isoform 2 *ENSGALG0000003061327
RET / ret proto-oncogene / P07949* / P35546* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment*ENSGALG0000000255526
FLT3 / fms related tyrosine kinase 3 / P36888*ENSGALG0000003572624


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR016248  Fibroblast growth factor receptor family
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010715 regulation of extracellular matrix disassembly IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0045862 positive regulation of proteolysis IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070857 regulation of bile acid biosynthetic process IEA
 biological_processGO:2000573 positive regulation of DNA biosynthetic process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030133 transport vesicle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005007 fibroblast growth factor-activated receptor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017134 fibroblast growth factor binding IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
betaKlotho-mediated ligand binding
FGFR4 ligand binding and activation
Phospholipase C-mediated cascade; FGFR4
FRS-mediated FGFR1 signaling
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR4 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001501 MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction
 ENSGALG00000004821 PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSGALG00000003750 PLCG1 / phospholipase C gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / reaction / complex
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000009898 GAB1 / GRB2 associated binding protein 1 / Q13480* / Q9QYY0*  / reaction / complex
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / complex / reaction
 ENSGALG00000028376 FGF19 / fibroblast growth factor 19 / Fgf15* / O95750* / O35622* / Fibroblast growth factor 15 *  / complex / reaction
 ENSGALG00000030943 KRAS / KRAS proto-oncogene, GTPase / P01116* / P32883* / GTPase KRas GTPase KRas, N-terminally processed*  / reaction
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / reaction / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction / complex
 ENSGALG00000028543 FGFR4 / fibroblast growth factor receptor 4 / P22455*  / complex / reaction
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction / complex
 ENSGALG00000009966 FRS2 / fibroblast growth factor receptor substrate 2 / Q8C180* / Q8WU20*  / complex / reaction
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / complex / reaction
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex / reaction






 

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