ENSGALG00000005802


Gallus gallus

Features
Gene ID: ENSGALG00000005802
  
Biological name :FLT4
  
Synonyms : FLT4 / fms related tyrosine kinase 4
  
Possible biological names infered from orthology : P35916 / P35917 / Vascular endothelial growth factor receptor 3
  
Species: Gallus gallus
  
Chr. number: 13
Strand: 1
Band:
Gene start: 13348919
Gene end: 13395196
  
Corresponding Affymetrix probe sets: Gga.15805.1.S1_at (Chicken Array)   Gga.439.1.S1_s_at (Chicken Array)   GgaAffx.26579.2.S1_at (Chicken Array)   GgaAffx.26579.3.S1_s_at (Chicken Array)   GgaAffx.26579.3.S1_x_at (Chicken Array)   GgaAffx.3625.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000009174
NCBI entrez gene - 395742     See in Manteia.
RefSeq - XM_015293744
RefSeq - NM_001293093
RefSeq - XM_015293742
RefSeq - XM_015293743
RefSeq Peptide - NP_001280022
swissprot - F1N871
Ensembl - ENSGALG00000005802
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 flt4ENSDARG00000104453Danio rerio
 FLT4ENSG00000037280Homo sapiens
 Flt4ENSMUSG00000020357Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KDR / vascular endothelial growth factor receptor 2 precursor / P35968* / kinase insert domain receptor*ENSGALG0000001390745
FLT1 / vascular endothelial growth factor receptor 1 precursor / P17948* / fms related tyrosine kinase 1*ENSGALG0000001709142
ENSGALG0000000764640
PDGFRA / platelet derived growth factor receptor alpha / P16234* / P26618* / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA.*ENSGALG0000001392923
PDGFRB / platelet derived growth factor receptor beta / P09619* / platelet-derived growth factor receptor beta isoform 2 *ENSGALG0000003061322
CSF1R / Gallus gallus colony stimulating factor 1 receptor (CSF1R), mRNA. / P07333* / P09581* / colony stimulating factor 1 receptor* / Macrophage colony-stimulating factor 1 receptor *ENSGALG0000000572522
KIT / Q08156 / Mast/stem cell growth factor receptor Kit / P05532* / P10721* / KIT proto-oncogene receptor tyrosine kinase*ENSGALG0000003863420
FLT3 / fms related tyrosine kinase 3 / P36888*ENSGALG0000003572619
FGFR4 / fibroblast growth factor receptor 4 / P22455*ENSGALG0000002854318
FGFR1 / fibroblast growth factor receptor 1 precursor / P11362* / P16092* / fibroblast growth factor receptor 1*ENSGALG0000003978618
FGFR2 / P18461 / Fibroblast growth factor receptor 2 / P21802* / fibroblast growth factor receptor 2 isoform 3 *ENSGALG0000000949518
FGFR3 / fibroblast growth factor receptor 3 / P22607* / Mus musculus fibroblast growth factor receptor 3 (Fgfr3), transcript variant 6, mRNA.*ENSGALG0000001570818
RET / ret proto-oncogene / P07949* / P35546* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment*ENSGALG0000000255517


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001824  Tyrosine-protein kinase, receptor class III, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR009137  Vascular endothelial growth factor receptor 3 (VEGFR3)
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0001944 vasculature development IEA
 biological_processGO:0001945 lymph vessel development IEA
 biological_processGO:0001946 lymphangiogenesis IEA
 biological_processGO:0002040 sprouting angiogenesis IEA
 biological_processGO:0003016 respiratory system process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007585 respiratory gaseous exchange IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IEA
 biological_processGO:0038084 vascular endothelial growth factor signaling pathway IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0048286 lung alveolus development IEA
 biological_processGO:0048514 blood vessel morphogenesis IEA
 biological_processGO:0060312 regulation of blood vessel remodeling IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0090037 positive regulation of protein kinase C signaling IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005021 vascular endothelial growth factor-activated receptor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0036328 VEGF-C-activated receptor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
VEGF binds to VEGFR leading to receptor dimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000005802 FLT4 / fms related tyrosine kinase 4 / P35916* / P35917* / Vascular endothelial growth factor receptor 3 *  / complex / reaction






 

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