ENSGALG00000017091


Gallus gallus

Features
Gene ID: ENSGALG00000017091
  
Biological name :FLT1
  
Synonyms : FLT1 / vascular endothelial growth factor receptor 1 precursor
  
Possible biological names infered from orthology : fms related tyrosine kinase 1 / P17948
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 175837246
Gene end: 175938674
  
Corresponding Affymetrix probe sets: Gga.150.1.S1_at (Chicken Array)   Gga.150.2.S1_a_at (Chicken Array)   Gga.150.2.S2_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000027556
NCBI entrez gene - 374100     See in Manteia.
RefSeq - NM_204252
RefSeq Peptide - NP_989583
swissprot - F1P382
Ensembl - ENSGALG00000017091
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 flt1ENSDARG00000019371Danio rerio
 FLT1ENSG00000102755Homo sapiens
 Flt1ENSMUSG00000029648Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENSGALG0000000764646
KDR / vascular endothelial growth factor receptor 2 precursor / P35968* / kinase insert domain receptor*ENSGALG0000001390744
FLT4 / fms related tyrosine kinase 4 / P35916* / P35917* / Vascular endothelial growth factor receptor 3 *ENSGALG0000000580243
PDGFRA / platelet derived growth factor receptor alpha / P16234* / P26618* / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA.*ENSGALG0000001392923
PDGFRB / platelet derived growth factor receptor beta / P09619* / platelet-derived growth factor receptor beta isoform 2 *ENSGALG0000003061323
CSF1R / Gallus gallus colony stimulating factor 1 receptor (CSF1R), mRNA. / P07333* / P09581* / colony stimulating factor 1 receptor* / Macrophage colony-stimulating factor 1 receptor *ENSGALG0000000572522
KIT / Q08156 / Mast/stem cell growth factor receptor Kit / P05532* / P10721* / KIT proto-oncogene receptor tyrosine kinase*ENSGALG0000003863421
FGFR2 / P18461 / Fibroblast growth factor receptor 2 / P21802* / fibroblast growth factor receptor 2 isoform 3 *ENSGALG0000000949519
FLT3 / fms related tyrosine kinase 3 / P36888*ENSGALG0000003572619
FGFR1 / fibroblast growth factor receptor 1 precursor / P11362* / P16092* / fibroblast growth factor receptor 1*ENSGALG0000003978618
FGFR3 / fibroblast growth factor receptor 3 / P22607* / Mus musculus fibroblast growth factor receptor 3 (Fgfr3), transcript variant 6, mRNA.*ENSGALG0000001570818
FGFR4 / fibroblast growth factor receptor 4 / P22455*ENSGALG0000002854317
RET / ret proto-oncogene / P07949* / P35546* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment*ENSGALG0000000255517


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001824  Tyrosine-protein kinase, receptor class III, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR009135  Vascular endothelial growth factor receptor 1 (VEGFR1)
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002548 monocyte chemotaxis IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0010863 positive regulation of phospholipase C activity IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IEA
 biological_processGO:0036323 vascular endothelial growth factor receptor-1 signaling pathway IEA
 biological_processGO:0038084 vascular endothelial growth factor signaling pathway IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:1905563 negative regulation of vascular endothelial cell proliferation IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005021 vascular endothelial growth factor-activated receptor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0036326 VEGF-A-activated receptor activity IEA
 molecular_functionGO:0036327 VEGF-B-activated receptor activity IEA
 molecular_functionGO:0036332 placental growth factor-activated receptor activity IEA


Pathways (from Reactome)
Pathway description
Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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