ENSGALG00000035726


Gallus gallus

Features
Gene ID: ENSGALG00000035726
  
Biological name :FLT3
  
Synonyms : FLT3 / fms related tyrosine kinase 3
  
Possible biological names infered from orthology : P36888
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 176034740
Gene end: 176060887
  
Corresponding Affymetrix probe sets: GgaAffx.10948.1.S1_at (Chicken Array)   GgaAffx.10948.2.S1_s_at (Chicken Array)   GgaAffx.10948.3.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000054394
NCBI entrez gene - 100858422     See in Manteia.
RefSeq - XM_003640612
RefSeq - XM_015278776
swissprot - A0A1D5PNF3
Ensembl - ENSGALG00000035726
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 flt3ENSDARG00000058503Danio rerio
 FLT3ENSG00000122025Homo sapiens
 Flt3ENSMUSG00000042817Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CSF1R / Gallus gallus colony stimulating factor 1 receptor (CSF1R), mRNA. / P07333* / P09581* / colony stimulating factor 1 receptor* / Macrophage colony-stimulating factor 1 receptor *ENSGALG0000000572528
KIT / Q08156 / Mast/stem cell growth factor receptor Kit / P05532* / P10721* / KIT proto-oncogene receptor tyrosine kinase*ENSGALG0000003863428
PDGFRA / platelet derived growth factor receptor alpha / P16234* / P26618* / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA.*ENSGALG0000001392927
FLT1 / vascular endothelial growth factor receptor 1 precursor / P17948* / fms related tyrosine kinase 1*ENSGALG0000001709126
PDGFRB / platelet derived growth factor receptor beta / P09619* / platelet-derived growth factor receptor beta isoform 2 *ENSGALG0000003061326
FLT4 / fms related tyrosine kinase 4 / P35916* / P35917* / Vascular endothelial growth factor receptor 3 *ENSGALG0000000580226
KDR / vascular endothelial growth factor receptor 2 precursor / P35968* / kinase insert domain receptor*ENSGALG0000001390725
ENSGALG0000000764625
FGFR2 / P18461 / Fibroblast growth factor receptor 2 / P21802* / fibroblast growth factor receptor 2 isoform 3 *ENSGALG0000000949521
FGFR3 / fibroblast growth factor receptor 3 / P22607* / Mus musculus fibroblast growth factor receptor 3 (Fgfr3), transcript variant 6, mRNA.*ENSGALG0000001570821
RET / ret proto-oncogene / P07949* / P35546* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment*ENSGALG0000000255520
FGFR1 / fibroblast growth factor receptor 1 precursor / P11362* / P16092* / fibroblast growth factor receptor 1*ENSGALG0000003978620
FGFR4 / fibroblast growth factor receptor 4 / P22455*ENSGALG0000002854320


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001824  Tyrosine-protein kinase, receptor class III, conserved site
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR030118  Receptor-type tyrosine-protein kinase FLT3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030154 cell differentiation IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0043621 protein self-association IEA


Pathways (from Reactome)
Pathway description
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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