ENSG00000122025


Homo sapiens

Features
Gene ID: ENSG00000122025
  
Biological name :FLT3
  
Synonyms : FLT3 / fms related tyrosine kinase 3 / P36888
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q12.2
Gene start: 28003274
Gene end: 28100592
  
Corresponding Affymetrix probe sets: 206674_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000370374
Ensembl peptide - ENSP00000241453
NCBI entrez gene - 2322     See in Manteia.
OMIM - 136351
RefSeq - XM_017020489
RefSeq - NM_004119
RefSeq - XM_017020486
RefSeq - XM_017020487
RefSeq - XM_017020488
RefSeq - XM_011535015
RefSeq - XM_011535017
RefSeq - XM_011535018
RefSeq Peptide - NP_004110
swissprot - P36888
swissprot - E7ER61
Ensembl - ENSG00000122025
  
Related genetic diseases (OMIM): 601626 - Leukemia, acute myeloid, reduced survival in, somatic, 601626
  613065 - Leukemia, acute lymphoblastic, somatic, 613065
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 flt3ENSDARG00000058503Danio rerio
 FLT3ENSGALG00000035726Gallus gallus
 Flt3ENSMUSG00000042817Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KIT / P10721 / KIT proto-oncogene receptor tyrosine kinaseENSG0000015740430
CSF1R / P07333 / colony stimulating factor 1 receptorENSG0000018257830
P16234 / PDGFRA / platelet derived growth factor receptor alphaENSG0000013485328
P09619 / PDGFRB / platelet derived growth factor receptor betaENSG0000011372127
FLT4 / P35916 / fms related tyrosine kinase 4ENSG0000003728026
KDR / P35968 / kinase insert domain receptorENSG0000012805226
FLT1 / P17948 / fms related tyrosine kinase 1ENSG0000010275526
RET / P07949 / ret proto-oncogeneENSG0000016573122
FGFR1 / P11362 / fibroblast growth factor receptor 1ENSG0000007778221
FGFR2 / P21802 / fibroblast growth factor receptor 2ENSG0000006646821
FGFR3 / P22607 / fibroblast growth factor receptor 3ENSG0000006807821
FGFR4 / P22455 / fibroblast growth factor receptor 4ENSG0000016086721


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001824  Tyrosine-protein kinase, receptor class III, conserved site
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR030118  Receptor-type tyrosine-protein kinase FLT3
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001776 leukocyte homeostasis ISS
 biological_processGO:0002318 myeloid progenitor cell differentiation ISS
 biological_processGO:0002328 pro-B cell differentiation ISS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway ISS
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030183 B cell differentiation ISS
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0035726 common myeloid progenitor cell proliferation ISS
 biological_processGO:0038084 vascular endothelial growth factor signaling pathway IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein TAS
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0043406 positive regulation of MAP kinase activity TAS
 biological_processGO:0043410 positive regulation of MAPK cascade TAS
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity TAS
 biological_processGO:0046651 lymphocyte proliferation ISS
 biological_processGO:0046777 protein autophosphorylation TAS
 biological_processGO:0071345 cellular response to cytokine stimulus TAS
 biological_processGO:0071385 cellular response to glucocorticoid stimulus IEA
 biological_processGO:0097028 dendritic cell differentiation ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0004896 cytokine receptor activity ISS
 molecular_functionGO:0005021 vascular endothelial growth factor-activated receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035259 glucocorticoid receptor binding IEA
 molecular_functionGO:0042803 protein homodimerization activity TAS
 molecular_functionGO:0043621 protein self-association IMP


Pathways (from Reactome)
Pathway description
PI3K Cascade
Other interleukin signaling
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0006721 Acute lymphatic leukemia "A form of acute leukemia characterized by excess lympoblasts." [HPO:curators]
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 HP:0010982 Polygenic inheritance "A type of multifactorial inheritance governed by the simultaneous action of many (more than three) gene loci." [HPO:probinson, ISBN:978-0192628961]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000090554 FLT3LG / P49771 / fms related tyrosine kinase 3 ligand  / complex / reaction
 ENSG00000122025 FLT3 / P36888 / fms related tyrosine kinase 3  / reaction / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex
 ENSG00000033327 GAB2 / Q9UQC2 / GRB2 associated binding protein 2  / complex
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex






 

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