ENSG00000090554


Homo sapiens

Features
Gene ID: ENSG00000090554
  
Biological name :FLT3LG
  
Synonyms : FLT3LG / fms related tyrosine kinase 3 ligand / P49771
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.33
Gene start: 49474207
Gene end: 49486231
  
Corresponding Affymetrix probe sets: 206980_s_at (Human Genome U133 Plus 2.0 Array)   210607_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000473098
Ensembl peptide - ENSP00000471860
Ensembl peptide - ENSP00000472628
Ensembl peptide - ENSP00000204637
Ensembl peptide - ENSP00000468977
Ensembl peptide - ENSP00000469181
Ensembl peptide - ENSP00000469613
Ensembl peptide - ENSP00000469942
Ensembl peptide - ENSP00000470453
Ensembl peptide - ENSP00000471226
NCBI entrez gene - 2323     See in Manteia.
OMIM - 600007
RefSeq - XM_017026535
RefSeq - XM_005258683
RefSeq - XM_006723116
RefSeq - XM_011526675
RefSeq - XM_011526676
RefSeq - XM_011526677
RefSeq - XM_011526678
RefSeq - XM_011526682
RefSeq - XM_017026532
RefSeq - XM_017026533
RefSeq - XM_017026534
RefSeq - NM_001204502
RefSeq - NM_001204503
RefSeq - NM_001278637
RefSeq - NM_001278638
RefSeq - NM_001459
RefSeq - XM_005258680
RefSeq - XM_005258681
RefSeq - XM_005258682
RefSeq Peptide - NP_001191432
RefSeq Peptide - NP_001265566
RefSeq Peptide - NP_001265567
RefSeq Peptide - NP_001450
RefSeq Peptide - NP_001191431
swissprot - M0QYM9
swissprot - M0R2K0
swissprot - M0R3A6
swissprot - P49771
swissprot - M0QXI0
Ensembl - ENSG00000090554
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Flt3lENSMUSG00000110206Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004213  Flt3 ligand
 IPR009079  Four-helical cytokine-like, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030098 lymphocyte differentiation IEA
 biological_processGO:0030885 regulation of myeloid dendritic cell activation IEA
 biological_processGO:0032819 positive regulation of natural killer cell proliferation IEA
 biological_processGO:0032825 positive regulation of natural killer cell differentiation IEA
 biological_processGO:0035162 embryonic hemopoiesis IDA
 biological_processGO:0045663 positive regulation of myoblast differentiation IEA
 biological_processGO:0045787 positive regulation of cell cycle IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048873 homeostasis of number of cells within a tissue IEA
 biological_processGO:0071864 positive regulation of cell proliferation in bone marrow IEA
 biological_processGO:0071866 negative regulation of apoptotic process in bone marrow IEA
 biological_processGO:0090290 positive regulation of osteoclast proliferation IEA
 biological_processGO:1901741 positive regulation of myoblast fusion IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0031233 intrinsic component of external side of plasma membrane IEA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
Other interleukin signaling
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000090554 FLT3LG / P49771 / fms related tyrosine kinase 3 ligand  / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex
 ENSG00000122025 FLT3 / P36888 / fms related tyrosine kinase 3  / reaction / complex
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex
 ENSG00000033327 GAB2 / Q9UQC2 / GRB2 associated binding protein 2  / complex
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex






 

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contact: otassy@igbmc.fr