ENSG00000033327


Homo sapiens

Features
Gene ID: ENSG00000033327
  
Biological name :GAB2
  
Synonyms : GAB2 / GRB2 associated binding protein 2 / Q9UQC2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q14.1
Gene start: 78215297
Gene end: 78418348
  
Corresponding Affymetrix probe sets: 203853_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000354952
Ensembl peptide - ENSP00000433762
Ensembl peptide - ENSP00000431868
Ensembl peptide - ENSP00000343959
NCBI entrez gene - 9846     See in Manteia.
OMIM - 606203
RefSeq - XM_006718753
RefSeq - XM_011545408
RefSeq - NM_012296
RefSeq - NM_080491
RefSeq Peptide - NP_036428
RefSeq Peptide - NP_536739
swissprot - Q9UQC2
swissprot - E9PJE2
swissprot - E9PJ26
Ensembl - ENSG00000033327
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gab2ENSDARG00000105120Danio rerio
 Gab2ENSMUSG00000004508Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GAB4 / Q2WGN9 / GRB2 associated binding protein family member 4ENSG0000021556849
GAB1 / Q13480 / GRB2 associated binding protein 1ENSG0000010945839
GAB3 / Q8WWW8 / GRB2 associated binding protein 3ENSG0000016021929


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030316 osteoclast differentiation IMP
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0043306 positive regulation of mast cell degranulation ISS
 biological_processGO:0048015 phosphatidylinositol-mediated signaling ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding ISS
 molecular_functionGO:0043325 phosphatidylinositol-3,4-bisphosphate binding ISS


Pathways (from Reactome)
Pathway description
PI3K Cascade
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Role of LAT2/NTAL/LAB on calcium mobilization
RET signaling
Interleukin-15 signaling
Interleukin receptor SHC signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / reaction
 ENSG00000105647 O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2  / complex / reaction
 ENSG00000113525 IL5 / P05113 / interleukin 5  / complex
 ENSG00000125650 PSPN / O60542 / persephin  / complex
 ENSG00000091181 IL5RA / Q01344 / interleukin 5 receptor subunit alpha  / complex
 ENSG00000100368 CSF2RB / P32927 / colony stimulating factor 2 receptor beta common subunit  / complex
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000158869 FCER1G / P30273 / Fc fragment of IgE receptor Ig  / reaction
 ENSG00000168546 GFRA2 / O00451 / GDNF family receptor alpha 2  / complex
 ENSG00000164399 IL3 / P08700 / interleukin 3  / complex
 ENSG00000164400 CSF2 / P04141 / colony stimulating factor 2  / complex
 ENSG00000149534 MS4A2 / Q01362 / membrane spanning 4-domains A2  / reaction
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / reaction / complex
 ENSG00000171119 NRTN / Q99748 / neurturin  / complex
 ENSG00000146013 GFRA3 / O60609 / GDNF family receptor alpha 3  / complex
 ENSG00000186716 BCR / P11274 / BCR, RhoGEF and GTPase activating protein  / complex / reaction
 ENSG00000086730 LAT2 / Q9GZY6 / linker for activation of T cells family member 2  / complex / reaction
 ENSG00000125861 GFRA4 / Q9GZZ7 / GDNF family receptor alpha 4  / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / reaction / complex
 ENSG00000165731 RET / P07949 / ret proto-oncogene  / complex
 ENSG00000185291 IL3RA / P26951 / interleukin 3 receptor subunit alpha  / complex
 ENSG00000168621 GDNF / P39905 / glial cell derived neurotrophic factor  / complex
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction / complex
 ENSG00000157404 KIT / P10721 / KIT proto-oncogene receptor tyrosine kinase  / complex / reaction
 ENSG00000117407 ARTN / Q5T4W7 / artemin  / complex
 ENSG00000171608 O00329 / PIK3CD / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta  / complex / reaction
 ENSG00000151892 GFRA1 / P56159 / GDNF family receptor alpha 1  / complex
 ENSG00000049130 KITLG / P21583 / KIT ligand  / complex / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / complex / reaction
 ENSG00000090554 FLT3LG / P49771 / fms related tyrosine kinase 3 ligand  / complex
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / reaction / complex
 ENSG00000122025 FLT3 / P36888 / fms related tyrosine kinase 3  / complex
 ENSG00000198223 CSF2RA / P15509 / colony stimulating factor 2 receptor alpha subunit  / complex
 ENSG00000179639 FCER1A / P12319 / Fc fragment of IgE receptor Ia  / reaction
 ENSG00000211891 IGHE / P01854 / immunoglobulin heavy constant epsilon  / reaction
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / reaction
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr