ENSG00000211891


Homo sapiens

Features
Gene ID: ENSG00000211891
  
Biological name :IGHE
  
Synonyms : IGHE / immunoglobulin heavy constant epsilon / P01854
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q32.33
Gene start: 105597691
Gene end: 105601728
  
Corresponding Affymetrix probe sets: 1558438_a_at (Human Genome U133 Plus 2.0 Array)   217469_at (Human Genome U133 Plus 2.0 Array)   234373_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000374983
Ensembl peptide - ENSP00000492979
swissprot - A0A286YES5
swissprot - P01854
Ensembl - ENSG00000211891
  
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ighv1-4ENSDARG00000096355Danio rerio
 IgheENSMUSG00000087642Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IGHG1 / P01857 / immunoglobulin heavy constant gamma 1 (G1m marker)ENSG0000021189627
IGHG3 / immunoglobulin heavy constant gamma 3 (G3m marker)ENSG0000021189726
IGHG2 / P01859 / immunoglobulin heavy constant gamma 2 (G2m marker)ENSG0000021189326
IGHG4 / P01861 / immunoglobulin heavy constant gamma 4 (G4m marker)ENSG0000021189225
IGHM / P01871 / immunoglobulin heavy constant muENSG0000021189924
IGHA2 / P01877 / immunoglobulin heavy constant alpha 2 (A2m marker)ENSG0000021189021
IGHA1 / P01876 / immunoglobulin heavy constant alpha 1ENSG0000021189520


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006910 phagocytosis, recognition IBA
 biological_processGO:0006911 phagocytosis, engulfment IBA
 biological_processGO:0006955 immune response NAS
 biological_processGO:0006958 complement activation, classical pathway IBA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0042742 defense response to bacterium IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0050853 B cell receptor signaling pathway IBA
 biological_processGO:0050871 positive regulation of B cell activation IBA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042571 immunoglobulin complex, circulating IBA
 cellular_componentGO:0072562 blood microparticle IBA
 molecular_functionGO:0003823 antigen binding IBA
 molecular_functionGO:0034987 immunoglobulin receptor binding IBA


Pathways (from Reactome)
Pathway description
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / complex / reaction
 ENSG00000179639 FCER1A / P12319 / Fc fragment of IgE receptor Ia  / complex / -
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / reaction
 ENSG00000211891 IGHE / P01854 / immunoglobulin heavy constant epsilon  / -
 ENSG00000158869 FCER1G / P30273 / Fc fragment of IgE receptor Ig  / - / complex
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / reaction
 ENSG00000086730 LAT2 / Q9GZY6 / linker for activation of T cells family member 2  / reaction
 ENSG00000149534 MS4A2 / Q01362 / membrane spanning 4-domains A2  / complex / -
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / reaction
 ENSG00000033327 GAB2 / Q9UQC2 / GRB2 associated binding protein 2  / reaction
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / complex / reaction






 

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