ENSG00000086730


Homo sapiens

Features
Gene ID: ENSG00000086730
  
Biological name :LAT2
  
Synonyms : LAT2 / linker for activation of T cells family member 2 / Q9GZY6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q11.23
Gene start: 74199652
Gene end: 74229834
  
Corresponding Affymetrix probe sets: 211768_at (Human Genome U133 Plus 2.0 Array)   221581_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000417533
Ensembl peptide - ENSP00000419150
Ensembl peptide - ENSP00000433807
Ensembl peptide - ENSP00000420549
Ensembl peptide - ENSP00000420494
Ensembl peptide - ENSP00000275635
Ensembl peptide - ENSP00000344881
Ensembl peptide - ENSP00000354374
Ensembl peptide - ENSP00000381492
NCBI entrez gene - 7462     See in Manteia.
OMIM - 605719
RefSeq - XM_011516558
RefSeq - NM_014146
RefSeq - NM_032463
RefSeq - NM_032464
RefSeq Peptide - NP_115853
RefSeq Peptide - NP_054865
RefSeq Peptide - NP_115852
swissprot - C9JA24
swissprot - F8W947
swissprot - C9JDY7
swissprot - Q9GZY6
swissprot - C9JXP0
Ensembl - ENSG00000086730
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LAT2ENSGALG00000043302Gallus gallus
 Lat2ENSMUSG00000040751Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR031428  Linker for activation of T-cells family member 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002764 immune response-regulating signaling pathway IEA
 biological_processGO:0019722 calcium-mediated signaling IGI
 biological_processGO:0035556 intracellular signal transduction IGI
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0042113 B cell activation IEA
 biological_processGO:0043303 mast cell degranulation IEA
 biological_processGO:0050853 B cell receptor signaling pathway IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042629 mast cell granule IEA
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042169 SH2 domain binding IPI


Pathways (from Reactome)
Pathway description
Role of LAT2/NTAL/LAB on calcium mobilization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / reaction
 ENSG00000105647 O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2  / complex / reaction
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000158869 FCER1G / P30273 / Fc fragment of IgE receptor Ig  / reaction
 ENSG00000149534 MS4A2 / Q01362 / membrane spanning 4-domains A2  / reaction
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / reaction / complex
 ENSG00000033327 GAB2 / Q9UQC2 / GRB2 associated binding protein 2  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / reaction / complex
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / reaction / complex
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000179639 FCER1A / P12319 / Fc fragment of IgE receptor Ia  / reaction
 ENSG00000211891 IGHE / P01854 / immunoglobulin heavy constant epsilon  / reaction
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / reaction
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr