ENSG00000179639


Homo sapiens

Features
Gene ID: ENSG00000179639
  
Biological name :FCER1A
  
Synonyms : FCER1A / Fc fragment of IgE receptor Ia / P12319
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q23.2
Gene start: 159289714
Gene end: 159308224
  
Corresponding Affymetrix probe sets: 1562537_at (Human Genome U133 Plus 2.0 Array)   211734_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357096
Ensembl peptide - ENSP00000357097
NCBI entrez gene - 2205     See in Manteia.
OMIM - 147140
RefSeq - NM_002001
RefSeq Peptide - NP_001992
swissprot - E9PRN1
swissprot - P12319
Ensembl - ENSG00000179639
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Fcer1aENSMUSG00000005339Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FCGR3A / P08637 / Fc fragment of IgG receptor IIIaENSG0000020374735
FCGR3B / O75015 / Fc fragment of IgG receptor IIIbENSG0000016274733
FCGR1B / Q92637 / Fc fragment of IgG receptor IbENSG0000019801933
FCGR1A / P12314 / Fc fragment of IgG receptor IaENSG0000015033733
FCGR2C / Fc fragment of IgG receptor IIc (gene/pseudogene)ENSG0000024468232
FCGR2B / P31994 / Fc fragment of IgG receptor IIbENSG0000007269432
FCRLB / Q6BAA4 / Fc receptor like BENSG0000016274632
FCGR2A / P12318 / Fc fragment of IgG receptor IIaENSG0000014322629
FCRL4 / Q96PJ5 / Fc receptor like 4ENSG0000016351828
FCRL5 / Q96RD9 / Fc receptor like 5ENSG0000014329727
FCRL3 / Q96P31 / Fc receptor like 3ENSG0000016085625
FCRLA / Q7L513 / Fc receptor like AENSG0000013218522
FCRL6 / Q6DN72 / Fc receptor like 6ENSG0000018103617
FCRL2 / Q96LA5 / Fc receptor like 2ENSG0000013270416
FCRL1 / Q96LA6 / Fc receptor like 1ENSG000001635344


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0019863 IgE binding IEA


Pathways (from Reactome)
Pathway description
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000158869 FCER1G / P30273 / Fc fragment of IgE receptor Ig  / - / complex
 ENSG00000149534 MS4A2 / Q01362 / membrane spanning 4-domains A2  / complex / -
 ENSG00000033327 GAB2 / Q9UQC2 / GRB2 associated binding protein 2  / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / reaction
 ENSG00000179639 FCER1A / P12319 / Fc fragment of IgE receptor Ia  / -
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / reaction / complex
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / reaction
 ENSG00000086730 LAT2 / Q9GZY6 / linker for activation of T cells family member 2  / reaction
 ENSG00000211891 IGHE / P01854 / immunoglobulin heavy constant epsilon  / complex / -
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / complex / reaction






 

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