ENSG00000072694


Homo sapiens

Features
Gene ID: ENSG00000072694
  
Biological name :FCGR2B
  
Synonyms : Fc fragment of IgG receptor IIb / FCGR2B / P31994
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q23.3
Gene start: 161663147
Gene end: 161678654
  
Corresponding Affymetrix probe sets: 210889_s_at (Human Genome U133 Plus 2.0 Array)   211395_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000236937
Ensembl peptide - ENSP00000351497
Ensembl peptide - ENSP00000356938
NCBI entrez gene - 2213     See in Manteia.
OMIM - 604590
RefSeq - NM_004001
RefSeq - XM_017000672
RefSeq - NM_001002273
RefSeq - NM_001002274
RefSeq - NM_001002275
RefSeq - NM_001190828
RefSeq - XM_017000669
RefSeq - XM_017000670
RefSeq - XM_017000671
RefSeq Peptide - NP_003992
RefSeq Peptide - NP_001002273
RefSeq Peptide - NP_001002274
RefSeq Peptide - NP_001002275
RefSeq Peptide - NP_001177757
swissprot - P31994
Ensembl - ENSG00000072694
  
Related genetic diseases (OMIM): 152700 - {Systemic lupus erythematosus, susceptibility to}, 152700
  611162 - {Malaria, resistance to}, 611162
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Fcgr2bENSMUSG00000026656Mus musculus
 Fcgr3ENSMUSG00000059498Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FCGR2C / Fc fragment of IgG receptor IIc (gene/pseudogene)ENSG0000024468285
FCGR2A / P12318 / Fc fragment of IgG receptor IIaENSG0000014322669
FCGR3B / O75015 / Fc fragment of IgG receptor IIIbENSG0000016274732
FCGR3A / P08637 / Fc fragment of IgG receptor IIIaENSG0000020374732
FCGR1A / P12314 / Fc fragment of IgG receptor IaENSG0000015033729
FCRLB / Q6BAA4 / Fc receptor like BENSG0000016274629
FCGR1B / Q92637 / Fc fragment of IgG receptor IbENSG0000019801928
FCRL5 / Q96RD9 / Fc receptor like 5ENSG0000014329727
FCER1A / P12319 / Fc fragment of IgE receptor IaENSG0000017963926
FCRL3 / Q96P31 / Fc receptor like 3ENSG0000016085622
FCRL4 / Q96PJ5 / Fc receptor like 4ENSG0000016351822
FCRLA / Q7L513 / Fc receptor like AENSG0000013218519
FCRL6 / Q6DN72 / Fc receptor like 6ENSG0000018103615
FCRL2 / Q96LA5 / Fc receptor like 2ENSG0000013270414
FCRL1 / Q96LA6 / Fc receptor like 1ENSG000001635346


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001811 negative regulation of type I hypersensitivity ISS
 biological_processGO:0001814 negative regulation of antibody-dependent cellular cytotoxicity TAS
 biological_processGO:0002266 follicular dendritic cell activation TAS
 biological_processGO:0002313 mature B cell differentiation involved in immune response TAS
 biological_processGO:0002316 follicular B cell differentiation TAS
 biological_processGO:0002436 immune complex clearance by monocytes and macrophages TAS
 biological_processGO:0002605 negative regulation of dendritic cell antigen processing and presentation TAS
 biological_processGO:0002622 regulation of B cell antigen processing and presentation TAS
 biological_processGO:0002638 negative regulation of immunoglobulin production ISS
 biological_processGO:0002819 regulation of adaptive immune response TAS
 biological_processGO:0002865 negative regulation of acute inflammatory response to antigenic stimulus ISS
 biological_processGO:0002922 positive regulation of humoral immune response TAS
 biological_processGO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin ISS
 biological_processGO:0006898 receptor-mediated endocytosis IDA
 biological_processGO:0006911 phagocytosis, engulfment ISS
 biological_processGO:0006952 defense response ISS
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0009617 response to bacterium ISS
 biological_processGO:0010469 regulation of signaling receptor activity TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016064 immunoglobulin mediated immune response ISS
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II ISS
 biological_processGO:0021549 cerebellum development ISS
 biological_processGO:0030889 negative regulation of B cell proliferation ISS
 biological_processGO:0032693 negative regulation of interleukin-10 production ISS
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis IDA
 biological_processGO:0043031 negative regulation of macrophage activation TAS
 biological_processGO:0043318 negative regulation of cytotoxic T cell degranulation TAS
 biological_processGO:0045088 regulation of innate immune response TAS
 biological_processGO:0046330 positive regulation of JNK cascade ISS
 biological_processGO:0050710 negative regulation of cytokine secretion TAS
 biological_processGO:0050765 negative regulation of phagocytosis TAS
 biological_processGO:0050766 positive regulation of phagocytosis ISS
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0050777 negative regulation of immune response ISS
 biological_processGO:0050869 negative regulation of B cell activation TAS
 biological_processGO:0071219 cellular response to molecule of bacterial origin ISS
 biological_processGO:0090264 regulation of immune complex clearance by monocytes and macrophages TAS
 biological_processGO:1901216 positive regulation of neuron death ISS
 biological_processGO:1902564 negative regulation of neutrophil activation TAS
 biological_processGO:1902950 regulation of dendritic spine maintenance IGI
 biological_processGO:1904646 cellular response to amyloid-beta ISS
 biological_processGO:1905898 positive regulation of response to endoplasmic reticulum stress ISS
 biological_processGO:2001199 negative regulation of dendritic cell differentiation TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0009897 external side of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043197 dendritic spine ISS
 cellular_componentGO:0044297 cell body ISS
 molecular_functionGO:0001540 amyloid-beta binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019772 low-affinity IgG receptor activity IDA
 molecular_functionGO:0019864 IgG binding IDA
 molecular_functionGO:0044877 protein-containing complex binding IPI


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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