ENSMUSG00000026656


Mus musculus

Features
Gene ID: ENSMUSG00000026656
  
Biological name :Fcgr2b
  
Synonyms : Fcgr2b
  
Possible biological names infered from orthology : Fc fragment of IgG receptor IIa / Fc fragment of IgG receptor IIb / Fc fragment of IgG receptor IIc (gene/pseudogene) / FCGR2A / FCGR2C / P12318 / P31994
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H3
Gene start: 170958617
Gene end: 170976547
  
Corresponding Affymetrix probe sets: 10360028 (MoGene1.0st)   1435476_a_at (Mouse Genome 430 2.0 Array)   1435477_s_at (Mouse Genome 430 2.0 Array)   1442118_at (Mouse Genome 430 2.0 Array)   1447622_at (Mouse Genome 430 2.0 Array)   1451941_a_at (Mouse Genome 430 2.0 Array)   1455332_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027966
Ensembl peptide - ENSMUSP00000137669
Ensembl peptide - ENSMUSP00000123774
Ensembl peptide - ENSMUSP00000079882
NCBI entrez gene - 14130     See in Manteia.
MGI - MGI:95499
RefSeq - NM_010187
RefSeq - NM_001077189
RefSeq Peptide - NP_034317
RefSeq Peptide - NP_001070657
swissprot - A0A0B4J1G1
swissprot - E9Q415
swissprot - A0A0B4J1E6
Ensembl - ENSMUSG00000026656
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FCGR2AENSG00000143226Homo sapiens
 FCGR2BENSG00000072694Homo sapiens
 FCGR2CENSG00000244682Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fcgr3 / Mus musculus Fc receptor, IgG, low affinity III (Fcgr3), transcript variant 2, mRNA. / FCGR2C* / P31994* / FCGR2A* / FCGR2B* / P12318* / Fc fragment of IgG receptor IIb* / Fc fragme...ENSMUSG0000005949854
Fcgr1 / P26151 / High affinity immunoglobulin gamma Fc receptor I / Q92637* / FCGR1A* / FCGR1B* / P12314* / Fc fragment of IgG receptor Ib* / Fc fragment of IgG receptor Ia*ENSMUSG0000001594728
Fcrlb / Q5DRQ8 / Fc receptor-like B / Q6BAA4*ENSMUSG0000007052426
Fcgr4 / A0A0B4J1G0 / Low affinity immunoglobulin gamma Fc region receptor IV / P08637* / FCGR3A* / FCGR3B* / O75015* / Fc fragment of IgG receptor IIIa* / Fc fragment of IgG receptor IIIb*ENSMUSG0000005908926
Fcrl5 / Q68SN8 / Fc receptor-like protein 5 / Q96RD9* / Fc receptor like 5*ENSMUSG0000004803120
Fcer1a / P20489 / High affinity immunoglobulin epsilon receptor subunit alpha / P12319* / Fc fragment of IgE receptor Ia*ENSMUSG0000000533920
Fcrla / Q920A9 / Fc receptor-like A / Q7L513*ENSMUSG0000003842116
FcrlsENSMUSG0000001585211
Fcrl6 / A1YIY0 / Fc receptor-like protein 6 ENSMUSG0000007050411
Fcrl1 / Q96LA6* / Fc receptor like 1*ENSMUSG000000599946


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp1b1tm1.1Akra/Atp1b1tm1.1Akra,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

Allelic Composition: Fcgr2btm1.2Jsv/Fcgr2b+,X/Yaa
Genetic Background: involves: C57BL/6 * FVB/N * SB/Le

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0000540 abnormal urinary bladder epithelium morphology "malformation of the epithelial layer of the urinary bladder" [MGI:tc]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * BALB/c

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Fcgr2btm1.2Jsv/Fcgr2b+,X/Yaa
Genetic Background: involves: C57BL/6 * FVB/N * SB/Le

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: B6.129S4-Fcgr2btm1Ttk

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1.2Jsv,Sle21129P2/Ola/Sle21C57BL/6
Genetic Background: involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Tlr7tm1Flv/Y,X/Yaa
Genetic Background: B6.Cg-Fcgr2btm1Ttk Tlr7tm1Flv Yaa

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,X/Yaa
Genetic Background: B6.Cg-Fcgr2btm1Ttk Yaa

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * BALB/c

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001650 electrically induced seizures "high or low frequency electrical stimulation applied to induce seizure activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, wf:Wayne Frankel , TJL staff]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Tlr7tm1Flv/Y,X/Yaa
Genetic Background: B6.Cg-Fcgr2btm1Ttk Tlr7tm1Flv Yaa

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,X/Yaa
Genetic Background: B6.Cg-Fcgr2btm1Ttk Yaa

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Fcgr2btm1.2Jsv/Fcgr2btm1.2Jsv,Sle16C57BL/6/Sle16C57BL/6
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: B6.129S4-Fcgr2btm1Ttk

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17a+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001864 vasculitis "inflammation of a blood or lymph vessel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Fcgr2btm1.2Jsv/Fcgr2b+,X/Yaa
Genetic Background: involves: C57BL/6 * FVB/N * SB/Le

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: B6.129S4-Fcgr2btm1Ttk

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1.2Jsv,Sle21129P2/Ola/Sle21C57BL/6
Genetic Background: involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17a+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17atm1Yiw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Tlr7tm1Flv/Y,X/Yaa
Genetic Background: B6.Cg-Fcgr2btm1Ttk Tlr7tm1Flv Yaa

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,X/Yaa
Genetic Background: B6.Cg-Fcgr2btm1Ttk Yaa

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fcgr2btm1.2Jsv/Fcgr2btm1.2Jsv,Sle16C57BL/6/Sle16C57BL/6
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1.2Jsv,Sle21129P2/Ola/Sle21C57BL/6
Genetic Background: involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Tlr7tm1Flv/Y,X/Yaa
Genetic Background: B6.Cg-Fcgr2btm1Ttk Tlr7tm1Flv Yaa

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,X/Yaa
Genetic Background: B6.Cg-Fcgr2btm1Ttk Yaa

 MP:0002148 immune system: hypersensitivity "immune response that results in tissue injury" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dock8cpm/Dock8pri
Genetic Background: C57BL/6J-Dock8cpm/Dock8pri

 MP:0002194 maximal tonic hindlimb extension seizures "seizures induced by electrical stimulation of the brainstem; manifesting as a tonic-clonic flexion/extension sequence, starting in tonic extension of the forelimbs and terminating in a full tonic hindlimb extension, which is defined when the angle of the hindlimbs to the torso exceeds 90 degrees (although it is usually 180 degrees)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, wf:Wayne Frankel , TJL staff]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002420 abnormal adaptive immunity "anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gata4tm1Grg/Gata4tm1.1Wtp,Tg(Nkx2-5-cre)9Eno/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: B6.129S4-Fcgr2btm1Ttk

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Fcer1atm1Knt/Fcer1atm1Knt,Fcer2atm1Max/Fcer2atm1Max,Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fcer1atm1Knt/Fcer1atm1Knt,Fcer2atm1Max/Fcer2atm1Max,Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Fcgr2btm1.2Jsv/Fcgr2btm1.2Jsv,Sle16C57BL/6/Sle16C57BL/6
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: B6.129S4-Fcgr2btm1Ttk

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Fcgr2btm1Kgcs/Fcgr2b+
Genetic Background: involves: C57BL/6

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2tm2Sbn,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17a+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fcgr2btm1.2Jsv/Fcgr2btm1.2Jsv,Sle16C57BL/6/Sle16C57BL/6
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: B6.129S4-Fcgr2btm1Ttk

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1.2Jsv,Sle21129P2/Ola/Sle21C57BL/6
Genetic Background: involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003620 decreased urine output "decreased volume of urine produced and excreted" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * BALB/c

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Fcgr2btm1.2Jsv/Fcgr2btm1.2Jsv,Sle16C57BL/6/Sle16C57BL/6
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: B6.129S4-Fcgr2btm1Ttk

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk
Genetic Background: Not Specified

Allelic Composition: Fcgr2btm1Kgcs/Fcgr2b+
Genetic Background: involves: C57BL/6

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: B6.129S4-Fcgr2btm1Ttk

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * BALB/c

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1.2Jsv/Fcgr2b+,X/Yaa
Genetic Background: involves: C57BL/6 * FVB/N * SB/Le

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: B6.129S4-Fcgr2btm1Ttk

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1.2Jsv,Sle21129P2/Ola/Sle21C57BL/6
Genetic Background: involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17atm1Yiw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Kgcs/Fcgr2b+
Genetic Background: involves: C57BL/6

 MP:0004771 increased anti-single stranded DNA antibody level "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: B6.129S4-Fcgr2btm1Ttk

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1.2Jsv,Sle21129P2/Ola/Sle21C57BL/6
Genetic Background: involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17atm1Yiw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Tlr7tm1Flv/Y,X/Yaa
Genetic Background: B6.Cg-Fcgr2btm1Ttk Tlr7tm1Flv Yaa

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,X/Yaa
Genetic Background: B6.Cg-Fcgr2btm1Ttk Yaa

 MP:0004796 increased anti-histone antibody level "elevated level of antibodies to histones present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: B6.129S4-Fcgr2btm1Ttk

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1.2Jsv,Sle21129P2/Ola/Sle21C57BL/6
Genetic Background: involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1.2Jsv/Fcgr2b+,X/Yaa
Genetic Background: involves: C57BL/6 * FVB/N * SB/Le

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: B6.129S4-Fcgr2btm1Ttk

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1.2Jsv,Sle21129P2/Ola/Sle21C57BL/6
Genetic Background: involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Tlr7tm1Flv/Y,X/Yaa
Genetic Background: B6.Cg-Fcgr2btm1Ttk Tlr7tm1Flv Yaa

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,X/Yaa
Genetic Background: B6.Cg-Fcgr2btm1Ttk Yaa

 MP:0004802 decreased susceptibility to systemic lupus erythematosus "reduced likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17atm1Yiw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: C3tm1Crr/C3tm1Crr,Fcer1gtm1Rav/Fcer1gtm1Rav,Tg(Ins2-TFRC/OVA)296Wehi/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0004829 increased anti-chromatin antibody level "increase in the level of antibodies that recognize chromatin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1.2Jsv/Fcgr2b+,X/Yaa
Genetic Background: involves: C57BL/6 * FVB/N * SB/Le

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: B6.129S4-Fcgr2btm1Ttk

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1.2Jsv,Sle21129P2/Ola/Sle21C57BL/6
Genetic Background: involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Fcgr2btm1Kgcs/Fcgr2b+
Genetic Background: involves: C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: B6.129S4-Fcgr2btm1Ttk

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1.2Jsv,Sle21129P2/Ola/Sle21C57BL/6
Genetic Background: involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005065 abnormal neutrophil morphology "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17atm1Yiw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fcgr2btm1.2Jsv/Fcgr2btm1.2Jsv,Sle16C57BL/6/Sle16C57BL/6
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: B6.129S4-Fcgr2btm1Ttk

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Fcer1atm1Knt/Fcer1atm1Knt,Fcer2atm1Max/Fcer2atm1Max,Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2tm2Sbn,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17a+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17atm1Yiw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008121 increased myeloid dendritic cell number "greater number of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses" [PMID:10449155, PMID:9521319]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0008177 increased germinal center B cell number "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2tm2Sbn,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Fcgr2btm1Kgcs/Fcgr2b+
Genetic Background: involves: C57BL/6

 MP:0008481 increased spleen germinal center number "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17a+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17atm1Yiw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Fcgr2btm1Kgcs/Fcgr2b+
Genetic Background: involves: C57BL/6

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: B6.129S4-Fcgr2btm1Ttk

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Fcgr2btm1Kgcs/Fcgr2b+
Genetic Background: involves: C57BL/6

 MP:0008524 increased plasmacytoid dendritic cell number "greater number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * BALB/c

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17a+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17atm1Yiw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008783 decreased B cell apoptosis "reduction in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Kgcs/Fcgr2b+
Genetic Background: involves: C57BL/6

 MP:0009333 abnormal splenocyte physiology "any functional anomaly of a cell of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Tlr7tm1Flv/Y,X/Yaa
Genetic Background: B6.Cg-Fcgr2btm1Ttk Tlr7tm1Flv Yaa

 MP:0009646 urinary bladder inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the urinary bladder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * BALB/c

 MP:0011508 glomerular capillary thrombosis "formation or presence of a thrombus within the renal glomerular capillaries" [MGI:anna]
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Allelic Composition: Fcgr2btm1.2Jsv/Fcgr2btm1.2Jsv,Sle16C57BL/6/Sle16C57BL/6
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: B6.129S4-Fcgr2btm1Ttk

 MP:0020518 renal glomerular protein deposits "any anomalous accumulation of protein in the renal glomerulus" [HP:0030949]
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Allelic Composition: Fcgr2btm1Kgcs/Fcgr2b+
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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