ENSMUSG00000005339


Mus musculus

Features
Gene ID: ENSMUSG00000005339
  
Biological name :Fcer1a
  
Synonyms : Fcer1a / High affinity immunoglobulin epsilon receptor subunit alpha / P20489
  
Possible biological names infered from orthology : Fc fragment of IgE receptor Ia / P12319
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H3
Gene start: 173221284
Gene end: 173227214
  
Corresponding Affymetrix probe sets: 10360338 (MoGene1.0st)   1421775_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141932
Ensembl peptide - ENSMUSP00000056882
NCBI entrez gene - 14125     See in Manteia.
MGI - MGI:95494
RefSeq - NM_010184
RefSeq - XM_006496655
RefSeq Peptide - NP_034314
swissprot - A0A0A6YXC5
swissprot - P20489
Ensembl - ENSMUSG00000005339
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FCER1AENSG00000179639Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fcgr1 / P26151 / High affinity immunoglobulin gamma Fc receptor I / Q92637* / FCGR1A* / FCGR1B* / P12314* / Fc fragment of IgG receptor Ib* / Fc fragment of IgG receptor Ia*ENSMUSG0000001594734
Fcgr4 / A0A0B4J1G0 / Low affinity immunoglobulin gamma Fc region receptor IV / P08637* / FCGR3A* / FCGR3B* / O75015* / Fc fragment of IgG receptor IIIa* / Fc fragment of IgG receptor IIIb*ENSMUSG0000005908933
Fcrlb / Q5DRQ8 / Fc receptor-like B / Q6BAA4*ENSMUSG0000007052429
Fcgr3 / Mus musculus Fc receptor, IgG, low affinity III (Fcgr3), transcript variant 2, mRNA. / FCGR2C* / P31994* / FCGR2A* / FCGR2B* / P12318* / Fc fragment of IgG receptor IIb* / Fc fragme...ENSMUSG0000005949829
Fcgr2b / P31994* / FCGR2A* / FCGR2C* / P12318* / Fc fragment of IgG receptor IIa* / Fc fragment of IgG receptor IIb* / Fc fragment of IgG receptor IIc (gene/pseudogene)*ENSMUSG0000002665627
Fcrl5 / Q68SN8 / Fc receptor-like protein 5 / Q96RD9* / Fc receptor like 5*ENSMUSG0000004803122
Fcrla / Q920A9 / Fc receptor-like A / Q7L513*ENSMUSG0000003842116
FcrlsENSMUSG0000001585211
Fcrl6 / A1YIY0 / Fc receptor-like protein 6 ENSMUSG000000705048
Fcrl1 / Q96LA6* / Fc receptor like 1*ENSMUSG000000599942


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IDA
 biological_processGO:0001812 positive regulation of type I hypersensitivity IMP
 biological_processGO:0001820 serotonin secretion IMP
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0007166 cell surface receptor signaling pathway IMP
 biological_processGO:0007257 activation of JUN kinase activity IDA
 biological_processGO:0019370 leukotriene biosynthetic process IDA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway IEA
 biological_processGO:0043306 positive regulation of mast cell degranulation IDA
 biological_processGO:0045401 positive regulation of interleukin-3 biosynthetic process IDA
 biological_processGO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050850 positive regulation of calcium-mediated signaling IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045121 membrane raft TAS
 molecular_functionGO:0019767 IgE receptor activity IMP
 molecular_functionGO:0019863 IgE binding IMP


Pathways (from Reactome)
Pathway description
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Adora1tm1Rgrn/Adora1tm1Rgrn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Fcer1atm1Knt/Fcer1atm1Knt
Genetic Background: involves: 129 * BALB/c

Allelic Composition: Fcer1atm1Ftl/Fcer1atm1Ftl
Genetic Background: CBy.129S2-Fcer1atm1Ftl

Allelic Composition: Fcer1atm1Knt/Fcer1atm1Knt,Fcer2atm1Max/Fcer2atm1Max
Genetic Background: B6.Cg-Fcer1atm1Knt Fcer2atm1Max

Allelic Composition: Fcer1atm1Knt/Fcer1atm1Knt,Fcer2atm1Max/Fcer2atm1Max,Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fcer1atm1Knt/Fcer1atm1Knt,Fcer2atm1Max/Fcer2atm1Max
Genetic Background: B6.Cg-Fcer1atm1Knt Fcer2atm1Max

Allelic Composition: Fcer1atm1Knt/Fcer1atm1Knt,Fcer2atm1Max/Fcer2atm1Max,Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max

 MP:0002531 type I hypersensitivity reaction "a reaction manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology , 2nd edition:ISBN 0-397-51047-0]
Show

Allelic Composition: Suz12tm1Hko/Suz12tm1Hko
Genetic Background: Not Specified

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Suz12tm1Hko/Suz12tm1Hko
Genetic Background: Not Specified

 MP:0003423 reduced thrombolysis "reduced ability or inability to break up (lyse) blood clots that are restricting the blood flow" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:17427]
Show

Allelic Composition: Fcer1atm1Knt/Fcer1atm1Knt
Genetic Background: involves: 129 * BALB/c

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fcer1atm1Ftl/Fcer1atm1Ftl
Genetic Background: CBy.129S2-Fcer1atm1Ftl

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fcer1atm1Knt/Fcer1atm1Knt
Genetic Background: involves: 129 * BALB/c

Allelic Composition: Fcer1atm1Knt/Fcer1atm1Knt,Fcer2atm1Max/Fcer2atm1Max,Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Fcer1atm1Knt/Fcer1atm1Knt,Fcer2atm1Max/Fcer2atm1Max
Genetic Background: B6.Cg-Fcer1atm1Knt Fcer2atm1Max

 MP:0008603 decreased circulating interleukin-4 level "reduction in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Fcer1atm1Ftl/Fcer1atm1Ftl
Genetic Background: CBy.129S2-Fcer1atm1Ftl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000042228 Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*  / reaction / complex
 ENSMUSG00000005339 Fcer1a / P20489 / High affinity immunoglobulin epsilon receptor subunit alpha / P12319* / Fc fragment of IgE receptor Ia*  / -
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction
 ENSMUSG00000024680 Ms4a2 / P20490 / membrane-spanning 4-domains, subfamily A, member 2 / Q01362* / membrane spanning 4-domains A2*  / - / complex
 ENSMUSG00000058715 Fcer1g / P20491 / High affinity immunoglobulin epsilon receptor subunit gamma / P30273* / Fc fragment of IgE receptor Ig*  / - / complex






 

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