ENSMUSG00000058715


Mus musculus

Features
Gene ID: ENSMUSG00000058715
  
Biological name :Fcer1g
  
Synonyms : Fcer1g / High affinity immunoglobulin epsilon receptor subunit gamma / P20491
  
Possible biological names infered from orthology : Fc fragment of IgE receptor Ig / P30273
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H3
Gene start: 171229572
Gene end: 171234365
  
Corresponding Affymetrix probe sets: 10360070 (MoGene1.0st)   1418340_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141240
Ensembl peptide - ENSMUSP00000078875
NCBI entrez gene - 14127     See in Manteia.
MGI - MGI:95496
RefSeq - NM_010185
RefSeq Peptide - NP_034315
swissprot - A0A0A6YVS1
swissprot - P20491
Ensembl - ENSMUSG00000058715
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fcer1gENSDARG00000103276Danio rerio
 fcer1glENSDARG00000104077Danio rerio
 FCER1GENSG00000158869Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003110  Phosphorylated immunoreceptor signalling ITAM
 IPR021663  T-cell surface glycoprotein CD3 zeta subunit/High affinity IgE receptor gamma subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001798 positive regulation of type IIa hypersensitivity IMP
 biological_processGO:0001805 positive regulation of type III hypersensitivity IMP
 biological_processGO:0001812 positive regulation of type I hypersensitivity IMP
 biological_processGO:0002283 neutrophil activation involved in immune response IMP
 biological_processGO:0002292 T cell differentiation involved in immune response IMP
 biological_processGO:0002431 Fc receptor mediated stimulatory signaling pathway IMP
 biological_processGO:0002554 serotonin secretion by platelet IMP
 biological_processGO:0006911 phagocytosis, engulfment IMP
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0007166 cell surface receptor signaling pathway IMP
 biological_processGO:0007229 integrin-mediated signaling pathway IMP
 biological_processGO:0010543 regulation of platelet activation IMP
 biological_processGO:0016064 immunoglobulin mediated immune response IMP
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II IMP
 biological_processGO:0030593 neutrophil chemotaxis IMP
 biological_processGO:0031623 receptor internalization IDA
 biological_processGO:0032733 positive regulation of interleukin-10 production IMP
 biological_processGO:0032755 positive regulation of interleukin-6 production IMP
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IMP
 biological_processGO:0032765 positive regulation of mast cell cytokine production IMP
 biological_processGO:0033026 negative regulation of mast cell apoptotic process IMP
 biological_processGO:0038094 Fc-gamma receptor signaling pathway IDA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway IEA
 biological_processGO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I IMP
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0043306 positive regulation of mast cell degranulation IMP
 biological_processGO:0045087 innate immune response IMP
 biological_processGO:0045576 mast cell activation IMP
 biological_processGO:0050766 positive regulation of phagocytosis IMP
 biological_processGO:0050776 regulation of immune response IMP
 biological_processGO:0050778 positive regulation of immune response IMP
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0071404 cellular response to low-density lipoprotein particle stimulus IDA
 biological_processGO:0072659 protein localization to plasma membrane IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032998 Fc-epsilon receptor I complex IMP
 cellular_componentGO:0045121 membrane raft TAS
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019767 IgE receptor activity IMP
 molecular_functionGO:0019863 IgE binding IMP
 molecular_functionGO:0019864 IgG binding IMP
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Cell surface interactions at the vascular wall
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
Neutrophil degranulation
Platelet Adhesion to exposed collagen


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Hcst/Tyrobptm1Ttk/Hcst/Tyrobptm1Ttk
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001588 hemoglobin abnormalities "defects in the levels or the function of the oxygen-carrying protein of erythrocytes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Celsr1Crsh/Celsr1+,Ptk7chz/Ptk7+
Genetic Background: involves: 101/H * BALB/c * BALB/cAnN * C3H/HeH

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: involves: C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: involves: C57BL/6

 MP:0001819 abnormal immune cell physiology "abnormal function of the cells of the immune system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

 MP:0001835 abnormal antigen presentation "aberration in the process by which peptide is presented to lymphocytes in a form they can recognize " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Th/Th
Genetic Background: Not Specified

 MP:0001864 vasculitis "inflammation of a blood or lymph vessel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Th/Th
Genetic Background: Not Specified

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1.1Viv/Tyrobptm1.1Viv
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

 MP:0002435 abnormal effector T cell morphology/development "anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: involves: C57BL/6

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

 MP:0003038 decreased infarction size "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

 MP:0003795 abnormal bone structure 
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004256 abnormal maternal decidual layer morphology "anomaly in the structure of the maternal uterine-derived portion of the placenta" [PMID:11433360]
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Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1.1Viv/Tyrobptm1.1Viv
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1.1Viv/Tyrobptm1.1Viv
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004260 enlarged placenta "increased size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: 1700016L21RikTg(Itgax-DTR/EGFP)57Lan/0
Genetic Background: B6.FVB-1700016L21RikTg(Itgax-DTR/EGFP)57Lan/J

Allelic Composition: C3tm1Crr/C3tm1Crr,Fcer1gtm1Rav/Fcer1gtm1Rav,Tg(Ins2-TFRC/OVA)296Wehi/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0004828 decreased susceptibility to autoimmune hemolytic anemia "reduced likelihood that an organism will develop an abnormality of the immune system that destroys red blood cells (hemolysis) prematurely" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp1b1tm1.1Akra/Atp1b1tm1.1Akra,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0004867 decreased platelet calcium level "decreased concentration in the platelet of this bivalent element" [RGD:Rat Genome Database submission]
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Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

 MP:0004993 decreased bone resorption "reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Celsr1Crsh/Celsr1+,Ptk7chz/Ptk7+
Genetic Background: involves: 101/H * BALB/c * BALB/cAnN * C3H/HeH

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: involves: C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: 1700016L21RikTg(Itgax-DTR/EGFP)57Lan/0
Genetic Background: B6.FVB-1700016L21RikTg(Itgax-DTR/EGFP)57Lan/J

Allelic Composition: Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: involves: C57BL/6

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: involves: C57BL/6

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005614 decreased susceptibility to type III hypersensitivity reaction "less likelihood of or resistance to developing tissue injury mediated by immune complexes; generally involves immune complexes formed in the blood via Abs encountering circulating Ag; Ag-Ab complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: involves: C57BL/6

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0006298 abnormal platelet activation "anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug" [GO:0030168, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

 MP:0008042 abnormal NK T cell physiology "any functional anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: involves: C57BL/6

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clec4etm1Tks/Clec4etm1Tks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008158 increased diameter of femur "increased width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008352 absent gamma-delta intraepithelial T cell "absence of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000801, ISBN:0781735149]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: involves: C57BL/6

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: involves: C57BL/6

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: involves: C57BL/6

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: involves: C57BL/6

 MP:0008559 abnormal interferon-gamma secretion "anomaly in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Clec4etm1Tks/Clec4etm1Tks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: ArTfm/Ar+,EdaTa-25H/Eda+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: involves: C57BL/6J

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1.1Viv/Tyrobptm1.1Viv
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: involves: C57BL/6

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: ArTfm/Ar+,EdaTa-25H/Eda+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: ArTfm/Ar+,EdaTa-25H/Eda+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0008670 decreased interleukin-12b secretion "reduction in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: ArTfm/Ar+,EdaTa-25H/Eda+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0008680 abnormal interleukin-17 secretion "anomaly in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: involves: C57BL/6J

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: involves: C57BL/6

 MP:0008691 decreased interleukin-23 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells" [MESH:D12.644.276.374.465.759]
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Allelic Composition: ArTfm/Ar+,EdaTa-25H/Eda+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: ArTfm/Ar+,EdaTa-25H/Eda+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: involves: C57BL/6

Allelic Composition: Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: involves: C57BL/6J

 MP:0008817 hematoma "an abnormal localized accumulation of clotted or partially clotted blood in an organ or a soft tissue space as a result of localized hemorrhage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Celsr1Crsh/Celsr1+,Ptk7chz/Ptk7+
Genetic Background: involves: 101/H * BALB/c * BALB/cAnN * C3H/HeH

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: involves: C57BL/6J

 MP:0008876 decreased uterine NK cell number "reduced number of the uterine subset of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1.1Viv/Tyrobptm1.1Viv
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: involves: C57BL/6

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: involves: C57BL/6J

 MP:0010138 arteritis "inflammation of the walls of arteries, usually as a result of infection or auto-immune response" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: involves: C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0011427 mesangial cell hyperplasia "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
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Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

 MP:0011440 increased kidney cell proliferation "increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]
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Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

 MP:0011453 abnormal glomerular capillary endothelium morphology "any structural anomaly of the thin, extremely flattened layer of cells that line the interior surface of glomerular capillaries and is densely perforated by large transcellular pores (aka fenestrae or fenestrations) that, unlike those of other fenestrated capillaries, are generally thought to lack diaphragms" [MGI:anna]
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Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

 MP:0011506 glomerular crescent "formation of a crescent-shaped (semi-lunar) glomerular lesion corresponding to extracapillary proliferation of Bowman s capsular epithelium and acquiring a fibroblast-like spindled morphology, possibly stimulated by release of fibrinogen from a ruptured glomerular basement membrane; epithelial crescents occur in aggressive forms of glomerulonephritis, may be accompanied by collagen and fibrin deposition and/or monocyte and macrophage proliferation, may protrude into Bowman s space, and ultimately compress and destroy the glomerular tuft" [MGI:anna]
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Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

 MP:0012529 abnormal decidua basalis morphology "any structural anomaly of the area of uterine endometrium found between the implanted chorionic vesicle and the myometrium; with continued growth of the embryo, the decidua basalis becomes incorporated into the maternal component of the definitive placenta" [MGI:anna]
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Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1.1Viv/Tyrobptm1.1Viv
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012726 abnormal uterine spiral artery morphology "any structural anomaly of the corkscrew-like arteries in premenstrual or progestational endometrium; uterine spiral arteries play a vital role in supplying nutrients to the placenta and fetus, and are thus remodeled into highly dilated inelastic vessels by the action of invading trophoblast (physiological change)" [MGI:anna]
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Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1.1Viv/Tyrobptm1.1Viv
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012727 abnormal uterine spiral artery remodeling "any anomaly of the physiological conversion of the uterine spiral arteries into highly dilated vessels by the action of invading trophoblast; in pregnancy, trophoblast invasion and uterine spiral artery remodeling are important for lowering maternal vascular resistance and increasing uteroplacental blood flow; this process involves loss of smooth muscle and elastic lamina from the vessel wall, and significant dilation at the mouth of the vessel; impaired spiral artery remodeling has been implicated in preeclampsia, fetal growth restriction, and preterm labor" [MGI:anna]
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Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1.1Viv/Tyrobptm1.1Viv
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030072 round face "facial appearance is more circular than usual as viewed from the front" [HP:0000311]
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000042228 Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*  / reaction / complex
 ENSMUSG00000024680 Ms4a2 / P20490 / membrane-spanning 4-domains, subfamily A, member 2 / Q01362* / membrane spanning 4-domains A2*  / complex / -
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000023349 Clec4n / Q9JKF4 / C-type lectin domain family 6 member A / Q6EIG7* / CLEC6A* / C-type lectin domain containing 6A*  / complex
 ENSMUSG00000078810 Gp6 / P0C191 / Platelet glycoprotein VI / Q9HCN6* / glycoprotein VI platelet*  / reaction / complex
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction
 ENSMUSG00000005339 Fcer1a / P20489 / High affinity immunoglobulin epsilon receptor subunit alpha / P12319* / Fc fragment of IgE receptor Ia*  / - / complex
 ENSMUSG00000058715 Fcer1g / P20491 / High affinity immunoglobulin epsilon receptor subunit gamma / P30273* / Fc fragment of IgE receptor Ig*  / - / complex






 

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