ENSMUSG00000024680


Mus musculus

Features
Gene ID: ENSMUSG00000024680
  
Biological name :Ms4a2
  
Synonyms : membrane-spanning 4-domains, subfamily A, member 2 / Ms4a2 / P20490
  
Possible biological names infered from orthology : membrane spanning 4-domains A2 / Q01362
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 11615523
Gene end: 11623719
  
Corresponding Affymetrix probe sets: 10466216 (MoGene1.0st)   1421475_at (Mouse Genome 430 2.0 Array)   1443264_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139841
Ensembl peptide - ENSMUSP00000140628
Ensembl peptide - ENSMUSP00000025583
Ensembl peptide - ENSMUSP00000127373
NCBI entrez gene - 14126     See in Manteia.
MGI - MGI:95495
RefSeq - XM_017318060
RefSeq - NM_001276328
RefSeq - NM_001276329
RefSeq - NM_001276330
RefSeq - NM_013516
RefSeq Peptide - NP_001263257
RefSeq Peptide - NP_001263258
RefSeq Peptide - NP_038544
RefSeq Peptide - NP_001263259
swissprot - Q3UNT6
swissprot - P20490
swissprot - A0A087WPM9
swissprot - B2RTF7
swissprot - A0A0B4J1P0
Ensembl - ENSMUSG00000024680
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MS4A2ENSG00000149534Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ms4a3 / Q920C4 / Membrane-spanning 4-domains subfamily A member 3 / Q96HJ5* / membrane spanning 4-domains A3*ENSMUSG0000002468121


Protein motifs (from Interpro)
Interpro ID Name
 IPR007237  CD20-like family
 IPR030417  Membrane-spanning 4-domains subfamily A
 IPR030420  High affinity immunoglobulin epsilon receptor subunit beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response ISO
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0007166 cell surface receptor signaling pathway IDA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032998 Fc-epsilon receptor I complex IEA
 cellular_componentGO:0045121 membrane raft TAS
 molecular_functionGO:0019863 IgE binding IDA


Pathways (from Reactome)
Pathway description
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mcm3aptm1Imku/Mcm3aptm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Ms4a2tm1Knt/Ms4a2tm1Knt,Tg(SV40/HTLV-FCER1A)1Bhk/0
Genetic Background: involves: 129 * BALB/c

Allelic Composition: Ms4a2tm1Knt/Ms4a2tm1Knt
Genetic Background: involves: 129 * BALB/c

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ms4a2tm1Knt/Ms4a2tm1Knt,Tg(SV40/HTLV-FCER1A)1Bhk/0
Genetic Background: involves: 129 * BALB/c

Allelic Composition: Ms4a2tm1Knt/Ms4a2tm1Knt
Genetic Background: involves: 129 * BALB/c

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mcm3aptm1Imku/Mcm3aptm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Ms4a2tm1Knt/Ms4a2tm1Knt,Tg(SV40/HTLV-FCER1A)1Bhk/0
Genetic Background: involves: 129 * BALB/c

Allelic Composition: Ms4a2tm1Knt/Ms4a2tm1Knt
Genetic Background: involves: 129 * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024680 Ms4a2 / P20490 / membrane-spanning 4-domains, subfamily A, member 2 / Q01362* / membrane spanning 4-domains A2*  / -
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / reaction / complex
 ENSMUSG00000042228 Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*  / reaction / complex
 ENSMUSG00000005339 Fcer1a / P20489 / High affinity immunoglobulin epsilon receptor subunit alpha / P12319* / Fc fragment of IgE receptor Ia*  / complex / -
 ENSMUSG00000058715 Fcer1g / P20491 / High affinity immunoglobulin epsilon receptor subunit gamma / P30273* / Fc fragment of IgE receptor Ig*  / complex / -






 

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