ENSG00000149534


Homo sapiens

Features
Gene ID: ENSG00000149534
  
Biological name :MS4A2
  
Synonyms : membrane spanning 4-domains A2 / MS4A2 / Q01362
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q12.1
Gene start: 60088261
Gene end: 60098466
  
Corresponding Affymetrix probe sets: 207496_at (Human Genome U133 Plus 2.0 Array)   207497_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433311
Ensembl peptide - ENSP00000482594
Ensembl peptide - ENSP00000278888
NCBI entrez gene - 2206     See in Manteia.
OMIM - 147138
RefSeq - XM_017017362
RefSeq - NM_000139
RefSeq - NM_001256916
RefSeq - XM_005273846
RefSeq - XM_011544850
RefSeq Peptide - NP_001243845
RefSeq Peptide - NP_000130
swissprot - E9PLJ1
swissprot - Q01362
swissprot - A0A0B4J2E9
Ensembl - ENSG00000149534
  
Related genetic diseases (OMIM): 147050 - {Atopy, susceptibility to}, 147050
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Ms4a2ENSMUSG00000024680Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MS4A3 / Q96HJ5 / membrane spanning 4-domains A3ENSG0000014951623


Protein motifs (from Interpro)
Interpro ID Name
 IPR007237  CD20-like family
 IPR030417  Membrane-spanning 4-domains subfamily A
 IPR030420  High affinity immunoglobulin epsilon receptor subunit beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032998 Fc-epsilon receptor I complex IEA
 molecular_functionGO:0019863 IgE binding IEA


Pathways (from Reactome)
Pathway description
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000149534 MS4A2 / Q01362 / membrane spanning 4-domains A2  / -
 ENSG00000033327 GAB2 / Q9UQC2 / GRB2 associated binding protein 2  / reaction
 ENSG00000179639 FCER1A / P12319 / Fc fragment of IgE receptor Ia  / complex / -
 ENSG00000158869 FCER1G / P30273 / Fc fragment of IgE receptor Ig  / complex / -
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / reaction / complex
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / reaction
 ENSG00000086730 LAT2 / Q9GZY6 / linker for activation of T cells family member 2  / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / reaction
 ENSG00000211891 IGHE / P01854 / immunoglobulin heavy constant epsilon  / complex / -
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / complex / reaction






 

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