ENSG00000158869


Homo sapiens

Features
Gene ID: ENSG00000158869
  
Biological name :FCER1G
  
Synonyms : FCER1G / Fc fragment of IgE receptor Ig / P30273
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q23.3
Gene start: 161215234
Gene end: 161220699
  
Corresponding Affymetrix probe sets: 1554899_s_at (Human Genome U133 Plus 2.0 Array)   204232_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000289902
Ensembl peptide - ENSP00000356971
NCBI entrez gene - 2207     See in Manteia.
OMIM - 147139
RefSeq - NM_004106
RefSeq Peptide - NP_004097
swissprot - A6NCQ8
swissprot - P30273
Ensembl - ENSG00000158869
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fcer1gENSDARG00000103276Danio rerio
 fcer1glENSDARG00000104077Danio rerio
 Fcer1gENSMUSG00000058715Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003110  Phosphorylated immunoreceptor signalling ITAM
 IPR021663  T-cell surface glycoprotein CD3 zeta subunit/High affinity IgE receptor gamma subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001798 positive regulation of type IIa hypersensitivity IEA
 biological_processGO:0001805 positive regulation of type III hypersensitivity IEA
 biological_processGO:0001812 positive regulation of type I hypersensitivity IEA
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0002283 neutrophil activation involved in immune response IEA
 biological_processGO:0002292 T cell differentiation involved in immune response IEA
 biological_processGO:0002431 Fc receptor mediated stimulatory signaling pathway IEA
 biological_processGO:0002554 serotonin secretion by platelet IEA
 biological_processGO:0006911 phagocytosis, engulfment IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0010543 regulation of platelet activation IEA
 biological_processGO:0016064 immunoglobulin mediated immune response IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II IEA
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0030593 neutrophil chemotaxis IEA
 biological_processGO:0031623 receptor internalization IEA
 biological_processGO:0032733 positive regulation of interleukin-10 production IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0032765 positive regulation of mast cell cytokine production IEA
 biological_processGO:0033026 negative regulation of mast cell apoptotic process IEA
 biological_processGO:0038094 Fc-gamma receptor signaling pathway IEA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway IMP
 biological_processGO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I IEA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0043306 positive regulation of mast cell degranulation IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045576 mast cell activation IEA
 biological_processGO:0050766 positive regulation of phagocytosis IEA
 biological_processGO:0050776 regulation of immune response IEA
 biological_processGO:0050778 positive regulation of immune response IEA
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0051260 protein homooligomerization IMP
 biological_processGO:0071404 cellular response to low-density lipoprotein particle stimulus IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032998 Fc-epsilon receptor I complex IEA
 cellular_componentGO:0070821 tertiary granule membrane TAS
 cellular_componentGO:0101003 ficolin-1-rich granule membrane TAS
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019767 IgE receptor activity IEA
 molecular_functionGO:0019863 IgE binding IBA
 molecular_functionGO:0019864 IgG binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IMP


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Cell surface interactions at the vascular wall
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
Dectin-2 family
Neutrophil degranulation
Platelet Adhesion to exposed collagen


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / reaction / complex
 ENSG00000166523 CLEC4E / Q9ULY5 / C-type lectin domain family 4 member E  / complex
 ENSG00000088053 GP6 / Q9HCN6 / glycoprotein VI platelet  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / reaction
 ENSG00000205846 CLEC6A / Q6EIG7 / C-type lectin domain containing 6A  / complex
 ENSG00000179639 FCER1A / P12319 / Fc fragment of IgE receptor Ia  / complex / -
 ENSG00000158869 FCER1G / P30273 / Fc fragment of IgE receptor Ig  / complex / -
 ENSG00000166527 CLEC4D / Q8WXI8 / C-type lectin domain family 4 member D  / complex
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / reaction
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / complex / reaction
 ENSG00000086730 LAT2 / Q9GZY6 / linker for activation of T cells family member 2  / reaction
 ENSG00000033327 GAB2 / Q9UQC2 / GRB2 associated binding protein 2  / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / reaction
 ENSG00000197943 PLCG2 / P16885 / phospholipase C gamma 2  / complex / reaction
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000149534 MS4A2 / Q01362 / membrane spanning 4-domains A2  / - / complex
 ENSG00000198178 CLEC4C / Q8WTT0 / C-type lectin domain family 4 member C  / complex
 ENSG00000211891 IGHE / P01854 / immunoglobulin heavy constant epsilon  / complex / -






 

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