Manteia

ENSG00000010810

Homo sapiens

Features

Gene ID:	ENSG00000010810

Biological name :	FYN

Synonyms :	FYN / FYN proto-oncogene, Src family tyrosine kinase / P06241

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	6
Strand:	-1
Band:	q21
Gene start:	111660332
Gene end:	111873452

Corresponding Affymetrix probe sets:	210105_s_at (Human Genome U133 Plus 2.0 Array) 212486_s_at (Human Genome U133 Plus 2.0 Array) 216033_s_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000427993 Ensembl peptide - ENSP00000357671 Ensembl peptide - ENSP00000428042 Ensembl peptide - ENSP00000440646 Ensembl peptide - ENSP00000430455 Ensembl peptide - ENSP00000430364 Ensembl peptide - ENSP00000429992 Ensembl peptide - ENSP00000429866 Ensembl peptide - ENSP00000429813 Ensembl peptide - ENSP00000429590 Ensembl peptide - ENSP00000429294 Ensembl peptide - ENSP00000428983 Ensembl peptide - ENSP00000428695 Ensembl peptide - ENSP00000428493 Ensembl peptide - ENSP00000428045 Ensembl peptide - ENSP00000229471 Ensembl peptide - ENSP00000346671 Ensembl peptide - ENSP00000357656 Ensembl peptide - ENSP00000357667 NCBI entrez gene - 2534 See in Manteia. OMIM - 137025 RefSeq - XM_017010655 RefSeq - NM_002037 RefSeq - NM_153047 RefSeq - NM_153048 RefSeq - XM_005266890 RefSeq - XM_005266892 RefSeq - XM_017010650 RefSeq - XM_017010651 RefSeq - XM_017010652 RefSeq - XM_017010653 RefSeq - XM_017010654 RefSeq Peptide - NP_002028 RefSeq Peptide - NP_694592 RefSeq Peptide - NP_694593 swissprot - E5RFM0 swissprot - E5RK23 swissprot - E5RJX7 swissprot - E5RIX5 swissprot - E5RI25 swissprot - E5RHX7 swissprot - E5RHF7 swissprot - E5RH71 swissprot - E5RGT0 swissprot - E5RGM6 swissprot - E5RFM6 swissprot - E5RFS5 swissprot - E5RFM4 swissprot - P06241 Ensembl - ENSG00000010810

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
fyna	ENSDARG00000011370	Danio rerio
fynb	ENSDARG00000025319	Danio rerio
FYN	ENSGALG00000015022	Gallus gallus
Fyn	ENSMUSG00000019843	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
YES1 / P07947 / YES proto-oncogene 1, Src family tyrosine kinase	ENSG00000176105	74
FGR / P09769 / FGR proto-oncogene, Src family tyrosine kinase	ENSG00000000938	70
SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase	ENSG00000197122	69
HCK / P08631 / HCK proto-oncogene, Src family tyrosine kinase	ENSG00000101336	57
LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase	ENSG00000254087	55
LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase	ENSG00000182866	54
BLK / P51451 / BLK proto-oncogene, Src family tyrosine kinase	ENSG00000136573	54
FRK / P42685 / fyn related Src family tyrosine kinase	ENSG00000111816	46
PTK6 / Q13882 / protein tyrosine kinase 6	ENSG00000101213	37
SRMS / Q9H3Y6 / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites	ENSG00000125508	36

Protein motifs (from Interpro)

Interpro ID	Name
IPR000719	Protein kinase domain
IPR000980	SH2 domain
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
IPR001452	SH3 domain
IPR008266	Tyrosine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR017441	Protein kinase, ATP binding site
IPR020635	Tyrosine-protein kinase, catalytic domain
IPR035750	Fyn/Yrk, SH3 domain
IPR036028	SH3-like domain superfamily
IPR036860	SH2 domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000165	MAPK cascade	TAS
biological_process	GO:0001764	neuron migration	IEA
biological_process	GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS
biological_process	GO:0002250	adaptive immune response	IEA
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0006468	protein phosphorylation	NAS
biological_process	GO:0006816	calcium ion transport	NAS
biological_process	GO:0007166	cell surface receptor signaling pathway	IEA
biological_process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007411	axon guidance	TAS
biological_process	GO:0007417	central nervous system development	IBA
biological_process	GO:0007596	blood coagulation	TAS
biological_process	GO:0007612	learning	TAS
biological_process	GO:0007631	feeding behavior	TAS
biological_process	GO:0008360	regulation of cell shape	IEA
biological_process	GO:0010629	negative regulation of gene expression	IEA
biological_process	GO:0010976	positive regulation of neuron projection development	IEA
biological_process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IEA
biological_process	GO:0016032	viral process	IEA
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0016477	cell migration	IBA
biological_process	GO:0018108	peptidyl-tyrosine phosphorylation	TAS
biological_process	GO:0019221	cytokine-mediated signaling pathway	TAS
biological_process	GO:0030154	cell differentiation	IBA
biological_process	GO:0030168	platelet activation	TAS
biological_process	GO:0030900	forebrain development	IEA
biological_process	GO:0031295	T cell costimulation	TAS
biological_process	GO:0031397	negative regulation of protein ubiquitination	IEA
biological_process	GO:0035556	intracellular signal transduction	TAS
biological_process	GO:0036120	cellular response to platelet-derived growth factor stimulus	IEA
biological_process	GO:0038083	peptidyl-tyrosine autophosphorylation	IBA
biological_process	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
biological_process	GO:0042110	T cell activation	IBA
biological_process	GO:0042127	regulation of cell proliferation	IBA
biological_process	GO:0042177	negative regulation of protein catabolic process	IEA
biological_process	GO:0042493	response to drug	IEA
biological_process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IEA
biological_process	GO:0042981	regulation of apoptotic process	IBA
biological_process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IEA
biological_process	GO:0043524	negative regulation of neuron apoptotic process	IEA
biological_process	GO:0045087	innate immune response	IBA
biological_process	GO:0045471	response to ethanol	IEA
biological_process	GO:0046777	protein autophosphorylation	IEA
biological_process	GO:0046854	phosphatidylinositol phosphorylation	IEA
biological_process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	TAS
biological_process	GO:0048013	ephrin receptor signaling pathway	TAS
biological_process	GO:0048813	dendrite morphogenesis	IEA
biological_process	GO:0050690	regulation of defense response to virus by virus	TAS
biological_process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	ISS
biological_process	GO:0050798	activated T cell proliferation	IEA
biological_process	GO:0050852	T cell receptor signaling pathway	IDA
biological_process	GO:0050900	leukocyte migration	TAS
biological_process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	IEA
biological_process	GO:0051897	positive regulation of protein kinase B signaling	TAS
biological_process	GO:0071363	cellular response to growth factor stimulus	IEA
biological_process	GO:0071375	cellular response to peptide hormone stimulus	IEA
biological_process	GO:0071560	cellular response to transforming growth factor beta stimulus	IEA
biological_process	GO:0090314	positive regulation of protein targeting to membrane	ISS
biological_process	GO:0097062	dendritic spine maintenance	TAS
biological_process	GO:1900182	positive regulation of protein localization to nucleus	IEA
biological_process	GO:1901216	positive regulation of neuron death	ISS
biological_process	GO:1902951	negative regulation of dendritic spine maintenance	ISS
biological_process	GO:1904645	response to amyloid-beta	ISS
biological_process	GO:1905232	cellular response to L-glutamate	ISS
biological_process	GO:1905430	cellular response to glycine	ISS
biological_process	GO:1905477	positive regulation of protein localization to membrane	TAS
biological_process	GO:1905664	regulation of calcium ion import across plasma membrane	ISS
biological_process	GO:2001056	positive regulation of cysteine-type endopeptidase activity	ISS
biological_process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005739	mitochondrion	IEA
cellular_component	GO:0005768	endosome	IDA
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0005884	actin filament	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0014069	postsynaptic density	ISS
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0030425	dendrite	ISS
cellular_component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	IBA
cellular_component	GO:0043231	intracellular membrane-bounded organelle	IEA
cellular_component	GO:0045121	membrane raft	TAS
cellular_component	GO:0071944	cell periphery	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0001664	G-protein coupled receptor binding	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004713	protein tyrosine kinase activity	ISS
molecular_function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IBA
molecular_function	GO:0004871	obsolete signal transducer activity	ISS
molecular_function	GO:0005088	Ras guanyl-nucleotide exchange factor activity	TAS
molecular_function	GO:0005102	signaling receptor binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0015631	tubulin binding	IEA
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0019899	enzyme binding	IEA
molecular_function	GO:0031802	type 5 metabotropic glutamate receptor binding	ISS
molecular_function	GO:0042608	T cell receptor binding	IEA
molecular_function	GO:0042609	CD4 receptor binding	IEA
molecular_function	GO:0042610	CD8 receptor binding	IEA
molecular_function	GO:0042802	identical protein binding	IPI
molecular_function	GO:0043548	phosphatidylinositol 3-kinase binding	IEA
molecular_function	GO:0044325	ion channel binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0046875	ephrin receptor binding	IPI
molecular_function	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	TAS
molecular_function	GO:0048156	tau protein binding	TAS
molecular_function	GO:0051428	peptide hormone receptor binding	IEA
molecular_function	GO:0070851	growth factor receptor binding	IPI
molecular_function	GO:0097718	disordered domain specific binding	IPI

Pathways (from Reactome)

Pathway description

GPVI-mediated activation cascade

Signaling by ERBB2

PIP3 activates AKT signaling

Signaling by SCF-KIT

Regulation of KIT signaling

Nef and signal transduction

Cell surface interactions at the vascular wall

FCGR activation

PECAM1 interactions

Constitutive Signaling by Aberrant PI3K in Cancer

DAP12 signaling

EPH-Ephrin signaling

Role of LAT2/NTAL/LAB on calcium mobilization

Nephrin family interactions

NCAM signaling for neurite out-growth

CD28 co-stimulation

CD28 dependent PI3K/Akt signaling

CD28 dependent Vav1 pathway

CTLA4 inhibitory signaling

EPHB-mediated forward signaling

EPHA-mediated growth cone collapse

Ephrin signaling

EPH-ephrin mediated repulsion of cells

Sema3A PAK dependent Axon repulsion

SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

CRMPs in Sema3A signaling

VEGFA-VEGFR2 Pathway

Dectin-2 family

CD209 (DC-SIGN) signaling

RAF/MAP kinase cascade

PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Platelet Adhesion to exposed collagen

Reelin signalling pathway

Regulation of signaling by CBL

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000105369	CD79A / P11912 / CD79a molecule	/ reaction
ENSG00000163554	SPTA1 / P02549 / spectrin alpha, erythrocytic 1	/ complex / reaction
ENSG00000254087	LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase	/ reaction / complex
ENSG00000163995	ABLIM2 / Q6H8Q1 / actin binding LIM protein family member 2	/ reaction / complex
ENSG00000221866	PLXNA4 / Q9HCM2 / plexin A4	/ complex
ENSG00000065320	NTN1 / O95631 / netrin 1	/ reaction / complex
ENSG00000169398	PTK2 / Q05397 / protein tyrosine kinase 2	/ complex / reaction
ENSG00000114013	CD86 / P42081 / CD86 molecule	/ complex / reaction
ENSG00000106299	WASL / O00401 / Wiskott-Aldrich syndrome like	/ reaction / complex
ENSG00000161270	NPHS1 / O60500 / NPHS1, nephrin	/ reaction / complex
ENSG00000070831	CDC42 / P60953 / cell division cycle 42	/ reaction / complex
ENSG00000187323	DCC / P43146 / DCC netrin 1 receptor	/ complex / reaction
ENSG00000071051	NCK2 / O43639 / NCK adaptor protein 2	/ reaction / complex
ENSG00000134215	VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3	/ complex / reaction
ENSG00000076356	O75051 / PLXNA2 / plexin A2	/ complex
ENSG00000086730	LAT2 / Q9GZY6 / linker for activation of T cells family member 2	/ reaction
ENSG00000121594	CD80 / P33681 / CD80 molecule	/ reaction / complex
ENSG00000166523	CLEC4E / Q9ULY5 / C-type lectin domain family 4 member E	/ reaction
ENSG00000105647	O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2	/ complex / reaction
ENSG00000141968	VAV1 / P15498 / vav guanine nucleotide exchange factor 1	/ reaction / complex
ENSG00000160691	SHC1 / P29353 / SHC adaptor protein 1	/ reaction
ENSG00000173210	ABLIM3 / O94929 / actin binding LIM protein family member 3	/ complex / reaction
ENSG00000150760	DOCK1 / Q14185 / dedicator of cytokinesis 1	/ reaction / complex
ENSG00000158869	FCER1G / P30273 / Fc fragment of IgE receptor Ig	/ complex / reaction
ENSG00000128052	KDR / P35968 / kinase insert domain receptor	/ complex / reaction
ENSG00000108262	GIT1 / Q9Y2X7 / GIT ArfGAP 1	/ complex / reaction
ENSG00000115904	SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1	/ reaction / complex
ENSG00000149294	NCAM1 / P13591 / neural cell adhesion molecule 1	/ complex / reaction
ENSG00000147852	VLDLR / P98155 / very low density lipoprotein receptor	/ reaction
ENSG00000038382	TRIO / O75962 / trio Rho guanine nucleotide exchange factor	/ complex / reaction
ENSG00000099204	ABLIM1 / O14639 / actin binding LIM protein 1	/ reaction / complex
ENSG00000160293	VAV2 / P52735 / vav guanine nucleotide exchange factor 2	/ complex / reaction
ENSG00000010810	FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase	/ reaction / complex
ENSG00000273079	GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2B	/ complex / reaction
ENSG00000099250	NRP1 / O14786 / neuropilin 1	/ reaction / complex
ENSG00000112715	VEGFA / P15692 / vascular endothelial growth factor A	/ reaction / complex
ENSG00000173406	DAB1 / O75553 / DAB1, reelin adaptor protein	/ reaction
ENSG00000088538	DOCK3 / Q8IZD9 / dedicator of cytokinesis 3	/ complex
ENSG00000158092	NCK1 / P16333 / NCK adaptor protein 1	/ reaction / complex
ENSG00000077264	PAK3 / O75914 / p21 (RAC1) activated kinase 3	/ complex / reaction
ENSG00000147010	Q96B97 / SH3KBP1 / SH3 domain containing kinase binding protein 1	/ reaction
ENSG00000171608	O00329 / PIK3CD / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	/ complex / reaction
ENSG00000136238	RAC1 / P63000 / Rac family small GTPase 1	/ complex / reaction
ENSG00000066248	NGEF / Q8N5V2 / neuronal guanine nucleotide exchange factor	/ reaction / complex
ENSG00000145675	P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1	/ reaction / complex
ENSG00000182866	LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase	/ complex / reaction
ENSG00000108947	EFNB3 / Q15768 / ephrin B3	/ reaction / complex
ENSG00000007312	CD79B / P40259 / CD79b molecule	/ reaction
ENSG00000110395	CBL / P22681 / Cbl proto-oncogene	/ complex / reaction
ENSG00000165025	SYK / P43405 / spleen associated tyrosine kinase	/ complex / reaction
ENSG00000183853	Q96J84 / KIRREL1 / kirre like nephrin family adhesion molecule 1	/ complex / reaction
ENSG00000102606	Q14155 / ARHGEF7 / Rho guanine nucleotide exchange factor 7	/ complex / reaction
ENSG00000182511	FES / P07332 / FES proto-oncogene, tyrosine kinase	/ reaction / complex
ENSG00000130827	P51805 / PLXNA3 / plexin A3	/ complex
ENSG00000051382	P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	/ reaction / complex
ENSG00000177885	GRB2 / P62993 / growth factor receptor bound protein 2	/ complex / reaction
ENSG00000132670	PTPRA / P18433 / protein tyrosine phosphatase, receptor type A	/ complex / reaction
ENSG00000088053	GP6 / Q9HCN6 / glycoprotein VI platelet	/ reaction / complex
ENSG00000075213	Q14563 / SEMA3A / semaphorin 3A	/ reaction / complex
ENSG00000090776	EFNB1 / P98172 / ephrin B1	/ complex / reaction
ENSG00000176749	CDK5R1 / Q15078 / cyclin dependent kinase 5 regulatory subunit 1	/ complex / reaction
ENSG00000156299	TIAM1 / Q13009 / T cell lymphoma invasion and metastasis 1	/ complex / reaction
ENSG00000114554	PLXNA1 / Q9UIW2 / plexin A1	/ complex
ENSG00000178562	CD28 / P10747 / CD28 molecule	/ reaction / complex
ENSG00000189056	RELN / P78509 / reelin	/ reaction
ENSG00000205846	CLEC6A / Q6EIG7 / C-type lectin domain containing 6A	/ reaction
ENSG00000149269	PAK1 / Q13153 / p21 (RAC1) activated kinase 1	/ complex / reaction
ENSG00000211899	IGHM / P01871 / immunoglobulin heavy constant mu	/ reaction
ENSG00000164885	CDK5 / Q00535 / cyclin dependent kinase 5	/ complex / reaction
ENSG00000125266	EFNB2 / P52799 / ephrin B2	/ reaction / complex
ENSG00000033327	GAB2 / Q9UQC2 / GRB2 associated binding protein 2	/ reaction
ENSG00000121879	P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	/ reaction / complex
ENSG00000197694	Q13813 / SPTAN1 / spectrin alpha, non-erythrocytic 1	/ reaction / complex
ENSG00000180370	PAK2 / Q13177 / p21 (RAC1) activated kinase 2	/ complex / reaction
ENSG00000211898	IGHD / P01880 / immunoglobulin heavy constant delta	/ reaction
ENSG00000213809	KLRK1 / P26718 / killer cell lectin like receptor K1	/ reaction / complex
ENSG00000082701	GSK3B / P49841 / glycogen synthase kinase 3 beta	/ reaction
ENSG00000006607	FARP2 / O94887 / FERM, ARH/RhoGEF and pleckstrin domain protein 2	/ reaction / complex
ENSG00000011600	O43914 / TYROBP / TYRO protein tyrosine kinase binding protein	/ reaction / complex
ENSG00000148053	NTRK2 / Q16620 / neurotrophic receptor tyrosine kinase 2	/ reaction / complex
ENSG00000172602	RND1 / Q92730 / Rho family GTPase 1	/ complex / reaction
ENSG00000100351	GRAP2 / O75791 / GRB2-related adaptor protein 2	/ reaction / complex
ENSG00000095970	TREM2 / Q9NZC2 / triggering receptor expressed on myeloid cells 2	/ complex / reaction
ENSG00000134539	KLRD1 / Q13241 / killer cell lectin like receptor D1	/ reaction / complex
ENSG00000176697	BDNF / P23560 / brain derived neurotrophic factor	/ complex / reaction
ENSG00000166710	B2M / P61769 / beta-2-microglobulin	/ reaction / complex
ENSG00000176884	GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1	/ reaction / complex
ENSG00000197122	SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase	/ reaction
ENSG00000198087	CD2AP / Q9Y5K6 / CD2 associated protein	/ complex / reaction
ENSG00000116218	NPHS2 / Q9NP85 / NPHS2, podocin	/ complex / reaction
ENSG00000205809	KLRC2 / P26717 / killer cell lectin like receptor C2	/ reaction / complex

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr