ENSG00000172602


Homo sapiens

Features
Gene ID: ENSG00000172602
  
Biological name :RND1
  
Synonyms : Q92730 / Rho family GTPase 1 / RND1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.12
Gene start: 48857145
Gene end: 48865898
  
Corresponding Affymetrix probe sets: 210056_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000447059
Ensembl peptide - ENSP00000449045
Ensembl peptide - ENSP00000308461
NCBI entrez gene - 27289     See in Manteia.
OMIM - 609038
RefSeq - NM_014470
RefSeq Peptide - NP_055285
swissprot - Q92730
swissprot - F8VXU4
swissprot - H0YHG7
Ensembl - ENSG00000172602
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnd1aENSDARG00000030547Danio rerio
 rnd1bENSDARG00000004218Danio rerio
 Rnd1ENSMUSG00000054855Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RND3 / P61587 / Rho family GTPase 3ENSG0000011596361
RND2 / P52198 / Rho family GTPase 2ENSG0000010883051
RHOC / P08134 / ras homolog family member CENSG0000015536636
RHOA / P61586 / ras homolog family member AENSG0000006756035
RHOB / P62745 / ras homolog family member BENSG0000014387834
RHOF / Q9HBH0 / ras homolog family member F, filopodia associatedENSG0000013972533
RHOD / O00212 / ras homolog family member DENSG0000017315632
AL603832.3ENSG0000027181024


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR003578  Small GTPase superfamily, Rho type
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization IDA
 biological_processGO:0007162 negative regulation of cell adhesion IDA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0016322 neuron remodeling IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005912 adherens junction IDA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity NAS
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Sema4D mediated inhibition of cell attachment and migration
Sema4D induced cell migration and growth-cone collapse


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000114554 PLXNA1 / Q9UIW2 / plexin A1  / reaction / complex
 ENSG00000143878 RHOB / P62745 / ras homolog family member B  / reaction
 ENSG00000160007 Q9NRY4 / ARHGAP35 / Rho GTPase activating protein 35  / reaction / complex
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000076356 O75051 / PLXNA2 / plexin A2  / complex / reaction
 ENSG00000164050 O43157 / PLXNB1 / plexin B1  / reaction / complex
 ENSG00000155366 RHOC / P08134 / ras homolog family member C  / reaction
 ENSG00000221866 PLXNA4 / Q9HCM2 / plexin A4  / complex / reaction
 ENSG00000187764 Q92854 / SEMA4D / semaphorin 4D  / complex / reaction
 ENSG00000099250 NRP1 / O14786 / neuropilin 1  / complex / reaction
 ENSG00000130827 P51805 / PLXNA3 / plexin A3  / complex / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction
 ENSG00000141736 ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2  / complex
 ENSG00000182511 FES / P07332 / FES proto-oncogene, tyrosine kinase  / complex / reaction
 ENSG00000196914 Q9NZN5 / ARHGEF12 / Rho guanine nucleotide exchange factor 12  / reaction / complex
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction / complex
 ENSG00000132694 O15085 / ARHGEF11 / Rho guanine nucleotide exchange factor 11  / complex / reaction
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / complex / reaction
 ENSG00000075213 Q14563 / SEMA3A / semaphorin 3A  / complex / reaction






 

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