ENSG00000130827


Homo sapiens

Features
Gene ID: ENSG00000130827
  
Biological name :PLXNA3
  
Synonyms : P51805 / plexin A3 / PLXNA3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: q28
Gene start: 154458281
Gene end: 154477779
  
Corresponding Affymetrix probe sets: 1553139_s_at (Human Genome U133 Plus 2.0 Array)   1567519_at (Human Genome U133 Plus 2.0 Array)   203623_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000358696
NCBI entrez gene - 55558     See in Manteia.
OMIM - 300022
RefSeq - XM_011531183
RefSeq - NM_017514
RefSeq - XM_005274706
RefSeq - XM_006724829
RefSeq - XM_005274705
RefSeq Peptide - NP_059984
swissprot - P51805
Ensembl - ENSG00000130827
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plxna3ENSDARG00000007172Danio rerio
 P70208ENSMUSG00000031398Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLXNA1 / Q9UIW2 / plexin A1ENSG0000011455467
O75051 / PLXNA2 / plexin A2ENSG0000007635660
PLXNA4 / Q9HCM2 / plexin A4ENSG0000022186660
O43157 / PLXNB1 / plexin B1ENSG0000016405035
PLXNB3 / Q9ULL4 / plexin B3ENSG0000019875333
O15031 / PLXNB2 / plexin B2ENSG0000019657631
PLXND1 / Q9Y4D7 / plexin D1ENSG0000000439930
O60486 / PLXNC1 / plexin C1ENSG0000013604021


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR002909  IPT domain
 IPR008936  Rho GTPase activation protein
 IPR013548  Plexin, cytoplasmic RasGAP domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR031148  Plexin family
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0021612 facial nerve structural organization IEA
 biological_processGO:0021637 trigeminal nerve structural organization IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0021785 branchiomotor neuron axon guidance IEA
 biological_processGO:0021860 pyramidal neuron development IEA
 biological_processGO:0048841 regulation of axon extension involved in axon guidance IBA
 biological_processGO:0048843 negative regulation of axon extension involved in axon guidance IEA
 biological_processGO:0050919 negative chemotaxis IEA
 biological_processGO:0051495 positive regulation of cytoskeleton organization IEA
 biological_processGO:0071526 semaphorin-plexin signaling pathway NAS
 biological_processGO:0097485 neuron projection guidance IEA
 biological_processGO:1902287 semaphorin-plexin signaling pathway involved in axon guidance IEA
 biological_processGO:1990138 neuron projection extension IEA
 cellular_componentGO:0002116 semaphorin receptor complex TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0004888 transmembrane signaling receptor activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017154 semaphorin receptor activity IEA


Pathways (from Reactome)
Pathway description
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex
 ENSG00000082701 GSK3B / P49841 / glycogen synthase kinase 3 beta  / reaction
 ENSG00000077264 PAK3 / O75914 / p21 (RAC1) activated kinase 3  / reaction / complex
 ENSG00000075213 Q14563 / SEMA3A / semaphorin 3A  / complex / reaction
 ENSG00000006607 FARP2 / O94887 / FERM, ARH/RhoGEF and pleckstrin domain protein 2  / complex / reaction
 ENSG00000099250 NRP1 / O14786 / neuropilin 1  / complex / reaction
 ENSG00000176749 CDK5R1 / Q15078 / cyclin dependent kinase 5 regulatory subunit 1  / complex / reaction
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / reaction / complex
 ENSG00000172602 RND1 / Q92730 / Rho family GTPase 1  / complex / reaction
 ENSG00000164885 CDK5 / Q00535 / cyclin dependent kinase 5  / reaction / complex
 ENSG00000182511 FES / P07332 / FES proto-oncogene, tyrosine kinase  / complex / reaction
 ENSG00000180370 PAK2 / Q13177 / p21 (RAC1) activated kinase 2  / reaction / complex
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / complex / reaction
 ENSG00000126458 RRAS / P10301 / RAS related  / reaction






 

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