ENSG00000006607


Homo sapiens

Features
Gene ID: ENSG00000006607
  
Biological name :FARP2
  
Synonyms : FARP2 / FERM, ARH/RhoGEF and pleckstrin domain protein 2 / O94887
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q37.3
Gene start: 241356243
Gene end: 241494841
  
Corresponding Affymetrix probe sets: 1554337_at (Human Genome U133 Plus 2.0 Array)   1558855_at (Human Genome U133 Plus 2.0 Array)   204511_at (Human Genome U133 Plus 2.0 Array)   225652_at (Human Genome U133 Plus 2.0 Array)   242857_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000412772
Ensembl peptide - ENSP00000411353
Ensembl peptide - ENSP00000415474
Ensembl peptide - ENSP00000486597
Ensembl peptide - ENSP00000264042
Ensembl peptide - ENSP00000362384
Ensembl peptide - ENSP00000388167
Ensembl peptide - ENSP00000393376
Ensembl peptide - ENSP00000403437
NCBI entrez gene - 9855     See in Manteia.
OMIM - 617586
RefSeq - XM_017005420
RefSeq - NM_014808
RefSeq - XM_005247050
RefSeq - XM_011512233
RefSeq - XM_011512234
RefSeq - XM_011512235
RefSeq - XM_011512236
RefSeq - XM_017005416
RefSeq - XM_017005417
RefSeq - XM_017005418
RefSeq - XM_017005419
RefSeq - NM_001282983
RefSeq - NM_001282984
RefSeq Peptide - NP_001269913
RefSeq Peptide - NP_055623
RefSeq Peptide - NP_001269912
swissprot - H7C3M7
swissprot - H7C447
swissprot - C9JWM9
swissprot - O94887
swissprot - C9JVQ5
swissprot - H7C210
swissprot - H7C3E4
Ensembl - ENSG00000006607
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 farp2ENSDARG00000016429Danio rerio
 FARP2ENSGALG00000005788Gallus gallus
 Farp2ENSMUSG00000034066Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FARP1 / Q9Y4F1 / FERM, ARH/RhoGEF and pleckstrin domain protein 1ENSG0000015276754
FRMD7 / Q6ZUT3 / FERM domain containing 7ENSG0000016569425
RDX / P35241 / radixinENSG0000013771015
EZR / ezrin / P15311ENSG0000009282014
MSN / moesin / P26038ENSG0000014706514
NF2 / P35240 / neurofibromin 2ENSG0000018657512
MYLIP / Q8WY64 / myosin regulatory light chain interacting proteinENSG0000000794411


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000299  FERM domain
 IPR000798  Ezrin/radixin/moesin-like
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR014847  FERM adjacent (FA)
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily
 IPR035963  FERM superfamily, second domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion ISS
 biological_processGO:0016322 neuron remodeling IDA
 biological_processGO:0016601 Rac protein signal transduction IDA
 biological_processGO:0022405 hair cycle process IEA
 biological_processGO:0030316 osteoclast differentiation ISS
 biological_processGO:0031532 actin cytoskeleton reorganization ISS
 biological_processGO:0033623 regulation of integrin activation ISS
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071526 semaphorin-plexin signaling pathway ISS
 biological_processGO:0071800 podosome assembly ISS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity ISS


Pathways (from Reactome)
Pathway description
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000075213 Q14563 / SEMA3A / semaphorin 3A  / reaction
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction
 ENSG00000186111 O60331 / PIP5K1C / phosphatidylinositol-4-phosphate 5-kinase type 1 gamma  / reaction / complex
 ENSG00000076356 O75051 / PLXNA2 / plexin A2  / reaction / complex
 ENSG00000099250 NRP1 / O14786 / neuropilin 1  / reaction / complex
 ENSG00000114554 PLXNA1 / Q9UIW2 / plexin A1  / complex / reaction
 ENSG00000221866 PLXNA4 / Q9HCM2 / plexin A4  / reaction / complex
 ENSG00000137076 TLN1 / Q9Y490 / talin 1  / reaction
 ENSG00000130827 P51805 / PLXNA3 / plexin A3  / reaction / complex






 

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