ENSG00000007944


Homo sapiens

Features
Gene ID: ENSG00000007944
  
Biological name :MYLIP
  
Synonyms : MYLIP / myosin regulatory light chain interacting protein / Q8WY64
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p22.3
Gene start: 16129125
Gene end: 16148248
  
Corresponding Affymetrix probe sets: 220319_s_at (Human Genome U133 Plus 2.0 Array)   223129_x_at (Human Genome U133 Plus 2.0 Array)   223130_s_at (Human Genome U133 Plus 2.0 Array)   227707_at (Human Genome U133 Plus 2.0 Array)   228097_at (Human Genome U133 Plus 2.0 Array)   228098_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000008686
Ensembl peptide - ENSP00000349298
NCBI entrez gene - 29116     See in Manteia.
OMIM - 610082
RefSeq - XM_017010789
RefSeq - NM_013262
RefSeq - XM_005249032
RefSeq - XM_005249033
RefSeq Peptide - NP_037394
swissprot - Q5TIA5
swissprot - Q8WY64
Ensembl - ENSG00000007944
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mylipaENSDARG00000008859Danio rerio
 mylipbENSDARG00000055118Danio rerio
 MYLIPENSGALG00000012704Gallus gallus
 MylipENSMUSG00000038175Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FARP1 / Q9Y4F1 / FERM, ARH/RhoGEF and pleckstrin domain protein 1ENSG0000015276725
FARP2 / O94887 / FERM, ARH/RhoGEF and pleckstrin domain protein 2ENSG0000000660725
RDX / P35241 / radixinENSG0000013771023
MSN / moesin / P26038ENSG0000014706522
FRMD7 / Q6ZUT3 / FERM domain containing 7ENSG0000016569421
EZR / ezrin / P15311ENSG0000009282021
NF2 / P35240 / neurofibromin 2ENSG0000018657520


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000798  Ezrin/radixin/moesin-like
 IPR001841  Zinc finger, RING-type
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR035963  FERM superfamily, second domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0010977 negative regulation of neuron projection development IMP
 biological_processGO:0010989 negative regulation of low-density lipoprotein particle clearance IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032802 low-density lipoprotein particle receptor catabolic process TAS
 biological_processGO:0032803 regulation of low-density lipoprotein particle receptor catabolic process IEA
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008092 cytoskeletal protein binding IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
VLDLR internalisation and degradation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000007944 MYLIP / Q8WY64 / myosin regulatory light chain interacting protein  / complex
 ENSG00000147852 VLDLR / P98155 / very low density lipoprotein receptor  / reaction






 

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