ENSDARG00000008859


Danio rerio

Features
Gene ID: ENSDARG00000008859
  
Biological name :mylipa
  
Synonyms : mylipa / myosin regulatory light chain interacting protein a / Q6TEM9
  
Possible biological names infered from orthology : E3 ubiquitin-protein ligase MYLIP / MYLIP / myosin regulatory light chain interacting protein / Q8BM54 / Q8WY64
  
Species: Danio rerio
  
Chr. number: 19
Strand: 1
Band:
Gene start: 26340736
Gene end: 26378655
  
Corresponding Affymetrix probe sets: Dr.20935.1.S1_at (Zebrafish Array)   NM_199983_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000012386
NCBI entrez gene - 335888     See in Manteia.
RefSeq - NM_199983
RefSeq Peptide - NP_956277
swissprot - Q6TEM9
ZFIN ID - ZDB-GENE-030131-7831
Ensembl - ENSDARG00000008859
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MYLIPENSGALG00000012704Gallus gallus
 MYLIPENSG00000007944Homo sapiens
 MylipENSMUSG00000038175Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mylipb / myosin regulatory light chain interacting protein b / MYLIP* / Q8BM54* / Q8WY64* / E3 ubiquitin-protein ligase MYLIP * / myosin regulatory light chain interacting protein*ENSDARG0000005511864
farp1 / FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) / Q9Y4F1* / F8VPU2* / FERM, ARH/RhoGEF and pleckstrin domain protein 1* / FERM, ARHGEF and pleckstrin dom...ENSDARG0000007438123
farp2 / FERM, RhoGEF and pleckstrin domain protein 2 / O94887* / Q91VS8* / FERM, ARH/RhoGEF and pleckstrin domain protein 2* / FERM, ARHGEF and pleckstrin domain-containing protein 2 *ENSDARG0000001642923
ezra / ezrin a / EZR* / ezrin* / P15311* / P26040*ENSDARG0000002094418
ezrb / sytl3 / synaptotagmin-like 3 / EZR* / ezrin* / P15311* / P26040*ENSDARG0000002509118
frmd7 / FERM domain containing 7 / A2AD83* / Q6ZUT3* / FERM domain-containing protein 7 *ENSDARG0000006895818
msnb / moesin b / MSN* / moesin* / P26038* / P26041*ENSDARG0000002874018
msna / moesin a / MSN* / moesin* / P26038* / P26041*ENSDARG0000005812817
si:ch211-243g6.3 / FRMD7* / A2AD83* / Q6ZUT3* / FERM domain containing 7* / FERM domain-containing protein 7 *ENSDARG0000007049517
nf2b / neurofibromin 2b (merlin)ENSDARG0000002556717
nf2a / neurofibromin 2a (merlin) / NF2* / P35240* / P46662* / Merlin * / neurofibromin 2*ENSDARG0000002020417
CABZ01066921.1ENSDARG000001120569


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR001841  Zinc finger, RING-type
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007369 gastrulation IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IGI
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
VLDLR internalisation and degradation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000006257 vldlr / very low density lipoprotein receptor / P98155* / P98156*  / reaction
 ENSDARG00000008859 mylipa / Q6TEM9 / myosin regulatory light chain interacting protein a / MYLIP* / Q8BM54* / Q8WY64* / E3 ubiquitin-protein ligase MYLIP * / myosin regulatory light chain interacting protein*  / complex






 

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