ENSDARG00000016429


Danio rerio

Features
Gene ID: ENSDARG00000016429
  
Biological name :farp2
  
Synonyms : farp2 / FERM, RhoGEF and pleckstrin domain protein 2
  
Possible biological names infered from orthology : FERM, ARHGEF and pleckstrin domain-containing protein 2 / FERM, ARH/RhoGEF and pleckstrin domain protein 2 / O94887 / Q91VS8
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 26948093
Gene end: 27038629
  
Corresponding Affymetrix probe sets: Dr.12847.1.A1_at (Zebrafish Array)   Dr.5587.1.A1_at (Zebrafish Array)   Dr.5587.2.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000129105
Ensembl peptide - ENSDARP00000129410
NCBI entrez gene - 567490     See in Manteia.
RefSeq - XM_009302421
RefSeq - XM_021477115
swissprot - X1WFV0
swissprot - E7FE33
ZFIN ID - ZDB-GENE-030131-2993
Ensembl - ENSDARG00000016429
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FARP2ENSGALG00000005788Gallus gallus
 FARP2ENSG00000006607Homo sapiens
 Farp2ENSMUSG00000034066Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
farp1 / FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) / Q9Y4F1* / F8VPU2* / FERM, ARH/RhoGEF and pleckstrin domain protein 1* / FERM, ARHGEF and pleckstrin dom...ENSDARG0000007438154
frmd7 / FERM domain containing 7 / A2AD83* / Q6ZUT3* / FERM domain-containing protein 7 *ENSDARG0000006895819
si:ch211-243g6.3 / FRMD7* / A2AD83* / Q6ZUT3* / FERM domain containing 7* / FERM domain-containing protein 7 *ENSDARG0000007049516
msna / moesin a / MSN* / moesin* / P26038* / P26041*ENSDARG0000005812814
ezra / ezrin a / EZR* / ezrin* / P15311* / P26040*ENSDARG0000002094414
msnb / moesin b / MSN* / moesin* / P26038* / P26041*ENSDARG0000002874013
ezrb / sytl3 / synaptotagmin-like 3 / EZR* / ezrin* / P15311* / P26040*ENSDARG0000002509113
nf2a / neurofibromin 2a (merlin) / NF2* / P35240* / P46662* / Merlin * / neurofibromin 2*ENSDARG0000002020412
nf2b / neurofibromin 2b (merlin)ENSDARG0000002556712
mylipa / Q6TEM9 / myosin regulatory light chain interacting protein a / MYLIP* / Q8BM54* / Q8WY64* / E3 ubiquitin-protein ligase MYLIP * / myosin regulatory light chain interacting protein*ENSDARG0000000885910
mylipb / myosin regulatory light chain interacting protein b / MYLIP* / Q8BM54* / Q8WY64* / E3 ubiquitin-protein ligase MYLIP * / myosin regulatory light chain interacting protein*ENSDARG000000551189
CABZ01066921.1ENSDARG000001120569


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000798  Ezrin/radixin/moesin-like
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR014847  FERM adjacent (FA)
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA


Pathways (from Reactome)
Pathway description
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000019328 plxna4 / plexin A4 / Q80UG2* / Q9HCM2*  / complex
 ENSDARG00000007172 plxna3 / plexin A3 / P51805* / P70208*  / complex
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSDARG00000076001 pip5k1ca / phosphatidylinositol-4-phosphate 5-kinase, type I, gamma a / O60331* / O70161* / PIP5K1C* / phosphatidylinositol-4-phosphate 5-kinase type 1 gamma*  / complex / reaction
 ENSDARG00000102153 nrp1a / neuropilin 1a / NRP1* / O14786* / P97333* / neuropilin 1*  / complex
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSDARG00000100729 tln1 / talin 1 / P26039* / Q9Y490*  / reaction
 ENSDARG00000100313 pip5k1cb / phosphatidylinositol-4-phosphate 5-kinase, type I, gamma b / O60331* / O70161* / PIP5K1C* / phosphatidylinositol-4-phosphate 5-kinase type 1 gamma*  / reaction / complex






 

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