ENSGALG00000005788


Gallus gallus

Features
Gene ID: ENSGALG00000005788
  
Biological name :FARP2
  
Synonyms : FARP2 / FERM, ARH/RhoGEF and pleckstrin domain protein 2
  
Possible biological names infered from orthology : FERM, ARHGEF and pleckstrin domain-containing protein 2 / O94887 / Q91VS8
  
Species: Gallus gallus
  
Chr. number: 9
Strand: 1
Band:
Gene start: 5007340
Gene end: 5061641
  
Corresponding Affymetrix probe sets: GgaAffx.26608.1.S1_at (Chicken Array)   GgaAffx.3619.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000009285
Ensembl peptide - ENSGALP00000054775
Ensembl peptide - ENSGALP00000047969
NCBI entrez gene - 424842     See in Manteia.
RefSeq - XM_422653
RefSeq - XM_015277081
RefSeq - XM_015277082
RefSeq - XM_015277083
RefSeq - XM_004937018
RefSeq - XM_004937019
RefSeq - XM_004937020
RefSeq - XM_015277080
swissprot - E1C5B7
swissprot - A0A1D5PPH5
swissprot - A0A1D5P5J8
Ensembl - ENSGALG00000005788
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 farp2ENSDARG00000016429Danio rerio
 FARP2ENSG00000006607Homo sapiens
 Farp2ENSMUSG00000034066Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FARP1 / FERM, ARH/RhoGEF and pleckstrin domain protein 1 / F8VPU2* / Q9Y4F1* / FERM, ARHGEF and pleckstrin domain-containing protein 1 *ENSGALG0000001688657
FRMD7 / FERM domain containing 7 / A2AD83* / Q6ZUT3* / FERM domain-containing protein 7 *ENSGALG0000002384324
RDX / radixin / P26043* / P35241*ENSGALG0000001715314
MSN / moesin / P26038* / P26041*ENSGALG0000003961514
EZRENSGALG0000001374213
NF2 / neurofibromin 2 / P35240* / P46662* / Merlin *ENSGALG0000000807312
MYLIP / myosin regulatory light chain interacting protein / Q8BM54* / Q8WY64* / E3 ubiquitin-protein ligase MYLIP *ENSGALG0000001270411
ENSGALG000000023674


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000299  FERM domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR014847  FERM adjacent (FA)
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0016322 neuron remodeling IEA
 biological_processGO:0016601 Rac protein signal transduction IEA
 biological_processGO:0022405 hair cycle process IEA
 biological_processGO:0030316 osteoclast differentiation IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0033623 regulation of integrin activation IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IEA
 biological_processGO:0071800 podosome assembly IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000784 PIP5K1C / Gallus gallus phosphatidylinositol-4-phosphate 5-kinase, type I, gamma (PIP5K1C), mRNA. / O60331* / O70161* / phosphatidylinositol-4-phosphate 5-kinase type 1 gamma*  / complex / reaction
 ENSGALG00000015022 FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSGALG00000001264 PLXNA2 / plexin A2 / O75051* / P70207*  / complex
 ENSGALG00000002548 TLN1 / talin-1 / P26039* / Q9Y490*  / reaction
 ENSGALG00000006097 PLXNA1 / plexin A1 / P70206* / Q9UIW2*  / complex






 

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