ENSGALG00000008073


Gallus gallus

Features
Gene ID: ENSGALG00000008073
  
Biological name :NF2
  
Synonyms : neurofibromin 2 / NF2
  
Possible biological names infered from orthology : Merlin / P35240 / P46662
  
Species: Gallus gallus
  
Chr. number: 15
Strand: -1
Band:
Gene start: 11120325
Gene end: 11160732
  
Corresponding Affymetrix probe sets: Gga.15944.1.A1_at (Chicken Array)   Gga.15944.1.S1_at (Chicken Array)   Gga.9141.1.S1_s_at (Chicken Array)   GgaAffx.12627.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000060183
Ensembl peptide - ENSGALP00000032938
Ensembl peptide - ENSGALP00000049488
NCBI entrez gene - 395158     See in Manteia.
RefSeq - XM_015294838
RefSeq - NM_204497
RefSeq - XM_015294835
RefSeq - XM_015294836
RefSeq - XM_015294837
RefSeq Peptide - NP_989828
swissprot - A0A1D5P9T0
swissprot - Q5ZJB0
swissprot - Q6RW63
Ensembl - ENSGALG00000008073
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nf2aENSDARG00000020204Danio rerio
 NF2ENSG00000186575Homo sapiens
 Nf2ENSMUSG00000009073Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RDX / radixin / P26043* / P35241*ENSGALG0000001715346
MSN / moesin / P26038* / P26041*ENSGALG0000003961545
EZRENSGALG0000001374244
FARP1 / FERM, ARH/RhoGEF and pleckstrin domain protein 1 / F8VPU2* / Q9Y4F1* / FERM, ARHGEF and pleckstrin domain-containing protein 1 *ENSGALG0000001688622
FARP2 / FERM, ARH/RhoGEF and pleckstrin domain protein 2 / O94887* / Q91VS8* / FERM, ARHGEF and pleckstrin domain-containing protein 2 *ENSGALG0000000578821
ENSGALG0000000236719
FRMD7 / FERM domain containing 7 / A2AD83* / Q6ZUT3* / FERM domain-containing protein 7 *ENSGALG0000002384318
MYLIP / myosin regulatory light chain interacting protein / Q8BM54* / Q8WY64* / E3 ubiquitin-protein ligase MYLIP *ENSGALG0000001270415


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000798  Ezrin/radixin/moesin-like
 IPR008954  Moesin tail domain superfamily
 IPR011174  Ezrin/radixin/moesin
 IPR011259  Ezrin/radixin/moesin, C-terminal
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001707 mesoderm formation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0007398 ectoderm development IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008156 negative regulation of DNA replication IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0014010 Schwann cell proliferation IEA
 biological_processGO:0014013 regulation of gliogenesis IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0022408 negative regulation of cell-cell adhesion IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0035330 regulation of hippo signaling IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0042532 negative regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043409 negative regulation of MAPK cascade IEA
 biological_processGO:0045216 cell-cell junction organization IEA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IEA
 biological_processGO:0050767 regulation of neurogenesis IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0070306 lens fiber cell differentiation IEA
 biological_processGO:0072091 regulation of stem cell proliferation IEA
 biological_processGO:1900180 regulation of protein localization to nucleus IEA
 biological_processGO:2000177 regulation of neural precursor cell proliferation IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IEA
 cellular_componentGO:0032154 cleavage furrow IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
RHO GTPases activate PAKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000681 PAK1 / p21 (RAC1) activated kinase 1 / Q13153* / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA.*  / complex / reaction






 

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