ENSMUSG00000009073


Mus musculus

Features
Gene ID: ENSMUSG00000009073
  
Biological name :Nf2
  
Synonyms : Merlin / Nf2 / P46662
  
Possible biological names infered from orthology : neurofibromin 2 / P35240
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A1
Gene start: 4765845
Gene end: 4849536
  
Corresponding Affymetrix probe sets: 10383897 (MoGene1.0st)   1421820_a_at (Mouse Genome 430 2.0 Array)   1427708_a_at (Mouse Genome 430 2.0 Array)   1450382_at (Mouse Genome 430 2.0 Array)   1451829_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130263
Ensembl peptide - ENSMUSP00000129388
Ensembl peptide - ENSMUSP00000132184
Ensembl peptide - ENSMUSP00000055033
Ensembl peptide - ENSMUSP00000055061
Ensembl peptide - ENSMUSP00000091066
Ensembl peptide - ENSMUSP00000105536
Ensembl peptide - ENSMUSP00000116505
Ensembl peptide - ENSMUSP00000128494
NCBI entrez gene - 18016     See in Manteia.
MGI - MGI:97307
RefSeq - XM_017314335
RefSeq - NM_001252252
RefSeq - NM_001252253
RefSeq - NM_010898
RefSeq - XM_006514569
RefSeq - XM_006514570
RefSeq - XM_006514571
RefSeq - XM_006514572
RefSeq - XM_006514573
RefSeq - XM_006514574
RefSeq - XM_011243669
RefSeq - XM_011243670
RefSeq - XM_017314334
RefSeq - NM_001252250
RefSeq - NM_001252251
RefSeq Peptide - NP_001239180
RefSeq Peptide - NP_001239181
RefSeq Peptide - NP_001239182
RefSeq Peptide - NP_035028
RefSeq Peptide - NP_001239179
swissprot - P46662
swissprot - E9PW99
swissprot - F6X089
swissprot - F7D6P2
swissprot - F7DBY2
swissprot - F8WJ43
swissprot - E9Q7I0
Ensembl - ENSMUSG00000009073
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nf2aENSDARG00000020204Danio rerio
 NF2ENSGALG00000008073Gallus gallus
 NF2ENSG00000186575Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rdx / P26043 / radixin / P35241*ENSMUSG0000003205046
Ezr / Ezrin / P26040 / P15311*ENSMUSG0000005239745
Msn / P26041 / Moesin / P26038*ENSMUSG0000003120744
Farp1 / F8VPU2 / FERM, ARHGEF and pleckstrin domain-containing protein 1 / Q9Y4F1* / FERM, ARH/RhoGEF and pleckstrin domain protein 1*ENSMUSG0000002555522
Farp2 / Q91VS8 / FERM, ARHGEF and pleckstrin domain-containing protein 2 / O94887* / FERM, ARH/RhoGEF and pleckstrin domain protein 2*ENSMUSG0000003406621
Frmd7 / A2AD83 / FERM domain-containing protein 7 / Q6ZUT3* / FERM domain containing 7*ENSMUSG0000003613119
Mylip / Q8BM54 / E3 ubiquitin-protein ligase MYLIP / Q8WY64* / myosin regulatory light chain interacting protein*ENSMUSG0000003817514


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000798  Ezrin/radixin/moesin-like
 IPR008954  Moesin tail domain superfamily
 IPR011174  Ezrin/radixin/moesin
 IPR011259  Ezrin/radixin/moesin, C-terminal
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR035963  FERM superfamily, second domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001707 mesoderm formation IMP
 biological_processGO:0006469 negative regulation of protein kinase activity IMP
 biological_processGO:0007398 ectoderm development IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0008156 negative regulation of DNA replication ISO
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0014010 Schwann cell proliferation ISO
 biological_processGO:0014013 regulation of gliogenesis IMP
 biological_processGO:0021766 hippocampus development IMP
 biological_processGO:0022408 negative regulation of cell-cell adhesion ISO
 biological_processGO:0030036 actin cytoskeleton organization ISO
 biological_processGO:0031647 regulation of protein stability IMP
 biological_processGO:0035330 regulation of hippo signaling ISO
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IMP
 biological_processGO:0042532 negative regulation of tyrosine phosphorylation of STAT protein ISO
 biological_processGO:0042981 regulation of apoptotic process ISS
 biological_processGO:0043409 negative regulation of MAPK cascade IMP
 biological_processGO:0045216 cell-cell junction organization IMP
 biological_processGO:0045597 positive regulation of cell differentiation IMP
 biological_processGO:0046426 negative regulation of JAK-STAT cascade ISO
 biological_processGO:0050767 regulation of neurogenesis IMP
 biological_processGO:0051496 positive regulation of stress fiber assembly ISO
 biological_processGO:0051726 regulation of cell cycle ISS
 biological_processGO:0070306 lens fiber cell differentiation IMP
 biological_processGO:0072091 regulation of stem cell proliferation IMP
 biological_processGO:1900180 regulation of protein localization to nucleus IMP
 biological_processGO:2000177 regulation of neural precursor cell proliferation IMP
 cellular_componentGO:0001726 ruffle IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005769 early endosome ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005912 adherens junction IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030175 filopodium IDA
 cellular_componentGO:0030864 cortical actin cytoskeleton IDA
 cellular_componentGO:0032154 cleavage furrow IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0044297 cell body IDA
 cellular_componentGO:0045177 apical part of cell IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008092 cytoskeletal protein binding IEA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
RHO GTPases activate PAKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)3Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm1Gth/Nf2tm2Gth,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2+,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53+,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0000121 failure of tooth eruption "inability of the teeth to grow into the oral cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Krt19tm2Mmt/Krt19tm2Mmt,Krt8tm1Rgo/Krt8tm1Rgo
Genetic Background: FVB.129S2-Krt19tm2Mmt Krt8tm1Rgo

Allelic Composition: Nf2tm1Gth/Nf2tm2Gth,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Cdkn2atm2Brn/Cdkn2atm2Brn,Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Cdkn2atm2Brn/Cdkn2a+,Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Yap1tm1.1Dupa/Yap1+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Yap1tm2.1Dupa/Yap1tm2.1Dupa
Genetic Background: involves: 129P2/OlaHsd

 MP:0000681 abnormal thyroid gland morphology "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0001077 abnormal spinal nerve morphology "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0001106 abnormal Schwann cell "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Krt19tm2Mmt/Krt19tm2Mmt,Krt8tm1Rgo/Krt8tm1Rgo
Genetic Background: FVB.129S2-Krt19tm2Mmt Krt8tm1Rgo

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)3Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm1Gth/Nf2tm2Gth,Tg(P0-Cre)1Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm1Gth/Nf2tm2Gth,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53+,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53tm1Brd,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Krt19tm2Mmt/Krt19tm2Mmt,Krt8tm1Rgo/Krt8tm1Rgo
Genetic Background: FVB.129S2-Krt19tm2Mmt Krt8tm1Rgo

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm1Gth/Nf2tm2Gth,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Krt19tm2Mmt/Krt19tm2Mmt,Krt8tm1Rgo/Krt8tm1Rgo
Genetic Background: FVB.129S2-Krt19tm2Mmt Krt8tm1Rgo

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm1Gth/Nf2tm2Gth,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001272 increased metastatic potential 
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Allelic Composition: Cdkn2atm1.1Brn/Cdkn2a+,Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)3Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53+,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53tm1Brd,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fpr2tm1.1Jimw/Fpr2tm1.1Jimw,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

Allelic Composition: Nf2tm2Gvn/Nf2+
Genetic Background: Not Specified

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0001512 trunk curl "posture of the trunk in a curled position" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0001704 abnormal dorsal-ventral axis patterning "anomaly in the development or formation of the axis that runs from the front to the back surface of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0001711 abnormal placenta 
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0001850 otitis media "middle ear inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
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Allelic Composition: Krt19tm2Mmt/Krt19tm2Mmt,Krt8tm1Rgo/Krt8tm1Rgo
Genetic Background: FVB.129S2-Krt19tm2Mmt Krt8tm1Rgo

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm1Gth/Nf2tm2Gth,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Nf2tm2Gth/Nf2+,Trp53tm1Brd/Trp53+,Tg(P0-Cre)3Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Krt19tm2Mmt/Krt19tm2Mmt,Krt8tm1Rgo/Krt8tm1Rgo
Genetic Background: FVB.129S2-Krt19tm2Mmt Krt8tm1Rgo

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Fpr2tm1.1Jimw/Fpr2tm1.1Jimw,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

Allelic Composition: Nf2tm2Gvn/Nf2+
Genetic Background: Not Specified

 MP:0002018 malignant tumors "higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Krt19tm2Mmt/Krt19tm2Mmt,Krt8tm1Rgo/Krt8tm1Rgo
Genetic Background: FVB.129S2-Krt19tm2Mmt Krt8tm1Rgo

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53tm1Brd,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Cdkn2atm1.1Brn/Cdkn2atm1.1Brn,Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Cdkn2atm2Brn/Cdkn2atm2Brn,Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Cdkn2atm2Brn/Cdkn2atm2Brn,Nf2tm2Gth/Nf2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cdkn2atm2Brn/Cdkn2a+,Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nf2tm2Gth/Nf2+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Cdkn2atm1.1Brn/Cdkn2a+,Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Cdkn2atm2Brn/Cdkn2atm2Brn,Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Cdkn2atm2Brn/Cdkn2atm2Brn,Nf2tm2Gth/Nf2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cdkn2atm2Brn/Cdkn2a+,Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nf2tm2Gth/Nf2+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

Allelic Composition: Nf2tm1Gth/Nf2+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2.1Gth/Nf2+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)3Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2+,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002030 neurofibrosarcoma "malignant neoplasm of fibrous tissue of the nervous system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Nf2tm1Gth/Nf2+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)3Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm1Gth/Nf2tm2Gth,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53+,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53tm1Brd,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53+,Tg(P0-Cre)3Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2+,Trp53tm1Brd/Trp53+,Tg(P0-Cre)3Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

Allelic Composition: Nf2tm1Gth/Nf2+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)3Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53+,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53tm1Brd,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0002035 leiomyosarcoma "malignant tumor derived from smooth (nonstriated) muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53+,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0002036 rhabdomyosarcoma "malignant tumor derived from skeletal (striated) muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53tm1Brd,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Cdkn2atm1.1Brn/Cdkn2atm1.1Brn,Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Cdkn2atm2Brn/Cdkn2atm2Brn,Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Cdkn2atm1.1Brn/Cdkn2a+,Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0002041 pituitary adenoma "appearance of benign neoplasms of the pituitary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Mir146tm2.1Bal/Mir146tm2.1Bal
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0002049 extremity angiosarcoma "malignant neoplasm of soft tissues; thought to arise from endothelial cells of blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53tm1Brd,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt19tm2Mmt/Krt19tm2Mmt,Krt8tm1Rgo/Krt8tm1Rgo
Genetic Background: FVB.129S2-Krt19tm2Mmt Krt8tm1Rgo

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)4Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm1Gth/Nf2tm2Gth,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53+,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53tm1Brd,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53+,Tg(P0-Cre)3Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2+,Trp53tm1Brd/Trp53+,Tg(P0-Cre)3Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Cdkn2atm1.1Brn/Cdkn2atm1.1Brn,Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Cdkn2atm2Brn/Cdkn2atm2Brn,Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Cdkn2atm2Brn/Cdkn2atm2Brn,Nf2tm2Gth/Nf2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cdkn2atm2Brn/Cdkn2a+,Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nf2tm2Gth/Nf2+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Ptgdstm1.1(cre)Gvn/Ptgds+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0002582 disorganized extraembryonic tissue "a lack of the regular arrangement of the membranes involved with the embryo s protection and nutrition" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0002583 absent extraembryonic ectoderm "missing layer of the endoderm of the extraembryonic tissue" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0002584 small ectoplacental cone 
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf2tm1Gth/Nf2+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)3Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm1Gth/Nf2tm2Gth,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53+,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53tm1Brd,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0003053 delayed tooth eruption "postponed onset of the growth of the teeth out of the gums" [pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
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Allelic Composition: Krt19tm2Mmt/Krt19tm2Mmt,Krt8tm1Rgo/Krt8tm1Rgo
Genetic Background: FVB.129S2-Krt19tm2Mmt Krt8tm1Rgo

Allelic Composition: Nf2tm1Gth/Nf2tm2Gth,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003252 abnormal bile duct physiology "anomalous action or function of the channels that secrete bile from the liver to the gall bladder and intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Yap1tm2.1Dupa/Yap1tm2.1Dupa
Genetic Background: involves: 129P2/OlaHsd

 MP:0003255 bile duct proliferation "the appearance of an increased number of bile ducts in the liver; a sign of progressive liver disease" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0003570 uterine leiomyoma "a benign tumor derived from the smooth muscle tissue of the uterus" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdkn2atm2Brn/Cdkn2atm2Brn,Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Cdkn2atm2Brn/Cdkn2atm2Brn,Nf2tm2Gth/Nf2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cdkn2atm2Brn/Cdkn2a+,Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nf2tm2Gth/Nf2+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0003789 osteosarcoma "malignant neoplasm derived from bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

Allelic Composition: Nf2tm1Gth/Nf2+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2.1Gth/Nf2+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)3Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53tm1Brd,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2+,Trp53tm1Brd/Trp53+,Tg(P0-Cre)3Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Ptgdstm1.1(cre)Gvn/Ptgds+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0004740 sensorineural hearing loss "a form of progressive hearing loss due to a lesion of the auditory division of cranial nerve VIII or the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0004839 bile duct hyperplasia "overdevelopment or increased size of the bile ducts, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0004986 abnormal osteoblast morphology "any structural anomaly of a bone-forming cell, which normally forms an osseous matrix (osteoid) in which it becomes enclosed as an osteocyte" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf2tm1Gth/Nf2+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)3Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm1Gth/Nf2tm2Gth,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53+,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53tm1Brd,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0005191 head tilt "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0005307 head tossing "compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf2tm2Gvn/Nf2tm2Gvn
Genetic Background: Not Specified

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fpr2tm1.1Jimw/Fpr2tm1.1Jimw,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

Allelic Composition: Nf2tm2Gvn/Nf2tm2Gvn
Genetic Background: Not Specified

Allelic Composition: Nf2tm2Gvn/Nf2+
Genetic Background: Not Specified

 MP:0005623 abnormal meninges "anomaly in any of the membranes covering the spinal cord and brain, including the dura mater (external), arachnoid (middle), and pia mater (internal)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, smb:Susan M. Bello , Mouse Genome Informatics Curator, J:48079]
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Allelic Composition: Cdkn2atm1.1Brn/Cdkn2atm1.1Brn,Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn2atm1.1Brn/Cdkn2atm1.1Brn,Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0008490 enlarged dorsal root ganglion "increased size a group of sensory nerve cell bodies located on the dorsal spinal roots within the vertebral column" [MESH:A08.340.390.340]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Krt19tm2Mmt/Krt19tm2Mmt,Krt8tm1Rgo/Krt8tm1Rgo
Genetic Background: FVB.129S2-Krt19tm2Mmt Krt8tm1Rgo

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)4Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm1Gth/Nf2tm2Gth,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm1Gth/Nf2tm2Gth,Tg(P0-Cre)3Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm1Gth/Nf2tm2Gth,Tg(P0-Cre)4Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm1Gth/Nf2tm2Gth,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53+,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53+,Tg(P0-Cre)3Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0010280 increased skeletal tumor incidence "greater than the expected number of neoplasms in the skeletal tissue, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf2tm2Gth/Nf2+,Trp53tm1Brd/Trp53+,Tg(P0-Cre)3Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0010281 increased nervous system tumor incidence "greater than the expected number of tumors originating in the nervous system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53+,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Ptgdstm1.1(cre)Gvn/Ptgds+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010297 increased hepatobiliary system tumor incidence 
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0010306 increased hamartoma incidence "greater than the expected number of benign focal malformations in a specific population in a given time period; results from faulty development of an organ, and is composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element normally present at that site" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf2tm1Gth/Nf2tm2Gth,Tg(P0-Cre)1Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Yap1tm2.1Dupa/Yap1tm2.1Dupa
Genetic Background: involves: 129P2/OlaHsd

 MP:0010309 increased mesothelioma incidence "greater than the expected number of neoplasms derived from the lining cells of the pleura and peritoneum, in a specific population in a given time period; is composed of spindle cells or fibrous tissue which may enclose glandlike spaces lined by cuboidal cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nf2tm1Gth/Nf2+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm1Gth/Nf2tm2Gth,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cdkn2atm1.1Brn/Cdkn2atm1.1Brn,Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Nf2tm2Gth/Nf2+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Cdkn2atm1.1Brn/Cdkn2a+,Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0010310 increased Schwannoma incidence "greater than the expected number of benign, encapsulated nerve sheath tumors composed of Schwann cells, in a specific population in a given time period; usually associated with a peripheral or cranial nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)3Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)4Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm1Gth/Nf2tm2Gth,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53+,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Cdkn2atm1.1Brn/Cdkn2atm1.1Brn,Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Nf2tm2Gth/Nf2+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0010311 increased meningioma incidence "greater than the expected number of encapsulated neoplasms derived from the meninges, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn2atm1.1Brn/Cdkn2atm1.1Brn,Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Ptgdstm1.1(cre)Gvn/Ptgds+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cdkn2atm1.1Brn/Cdkn2atm1.1Brn,Nf2tm2Gth/Nf2tm2Gth,Ptgdstm1.1(cre)Gvn/Ptgds+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010313 increased osteoma incidence "greater than the expected number of benign neoplasms derived from lamellar bone, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf2tm1Gth/Nf2+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2.1Gth/Nf2+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)3Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2+,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53tm1Brd,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2+,Trp53tm1Brd/Trp53+,Tg(P0-Cre)3Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Cdkn2atm1.1Brn/Cdkn2atm1.1Brn,Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Ptgdstm1.1(cre)Gvn/Ptgds+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010314 increased neurofibroma incidence "greater than the expected number of benign, encapsulated nerve sheath tumors composed of Schwann cells, in a specific population in a given time period; proliferation is disordered and includes portions of nerve fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf2tm1Gth/Nf2+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53+,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0010316 increased thyroid tumor incidence "greater than the expected number of neoplams in the thyroid occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0010334 pleural effusion "accumulation of excess fluid in the pleural cavity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn2atm1.1Brn/Cdkn2a+,Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0010347 osseous metaplasia "the formation of mature bone elements in the stroma of a neoplasm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf2tm1Gth/Nf2+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)3Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm1Gth/Nf2tm2Gth,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53+,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Trp53tm1Brd/Trp53tm1Brd,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Cdkn2atm1.1Brn/Cdkn2atm1.1Brn,Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010353 increased odontoma incidence "greater than the expected number of a hamartomatous odontogenic tumor composed of enamel, dentin, cementum, and pulp tissue that may or may not be arranged in the form of a tooth, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)3Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm1Gth/Nf2tm2Gth,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010354 increased odontosarcoma incidence "greater than the expected number of an a gnathic malignant connective tissue tumor in which the epithelial component is benign and the proliferative mesenchymal component is malignant, occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:10587276]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm1Gth/Nf2tm2Gth,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010363 increased fibrosarcoma incidence "greater than the expected number of a highly aggressive malignant neoplasm arising from fibrous connective tissue, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

Allelic Composition: Nf2tm2.1Gth/Nf2+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010364 increased fibroadenoma incidence "greater than the expected number of a benign mammary gland tumor composed of both fibrous tissue and glandular tissue, in a specific population in a given time period" [CDR:523438 "http://www.cancer.gov/dictionary/?CdrID=523438"]
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Allelic Composition: Nf2tm1Gth/Nf2+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)3Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2+,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010384 increased renal carcinoma incidence "greater than the expected number of malignant neoplasms arising from kidney epithelial tissue, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nf2tm1Gth/Nf2+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)3Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)#Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0010742 increased Schwann cell number "greater than normal number of cells that sheath the axons of the peripheral nervous system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Nf2tm1Gth/Nf2tm2Gth,Tg(P0-Cre)1Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Krt19tm2Mmt/Krt19tm2Mmt,Krt8tm1Rgo/Krt8tm1Rgo
Genetic Background: FVB.129S2-Krt19tm2Mmt Krt8tm1Rgo

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(P0-Cre)2Gth/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Nf2tm1Gth/Nf2+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011106 partial embryonic lethality before somite formation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0011966 abnormal auditory brainstem response waveform shape "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NTac

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0013611 abnormal bile duct epithelium morphology "any structural anomaly of the epithelium lining the intrahepatic and extrahepatic bile ducts" [MGI:Anna]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Yap1tm2.1Dupa/Yap1tm2.1Dupa
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / reaction / complex






 

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