ENSMUSG00000031207


Mus musculus

Features
Gene ID: ENSMUSG00000031207
  
Biological name :Msn
  
Synonyms : Moesin / Msn / P26041
  
Possible biological names infered from orthology : P26038
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: C3
Gene start: 96096042
Gene end: 96168552
  
Corresponding Affymetrix probe sets: 10600836 (MoGene1.0st)   1421814_at (Mouse Genome 430 2.0 Array)   1450379_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113071
NCBI entrez gene - 17698     See in Manteia.
MGI - MGI:97167
RefSeq - NM_010833
RefSeq Peptide - NP_034963
swissprot - P26041
Ensembl - ENSMUSG00000031207
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 msnaENSDARG00000058128Danio rerio
 msnbENSDARG00000028740Danio rerio
 MSNENSGALG00000039615Gallus gallus
 MSNENSG00000147065Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rdx / P26043 / radixin / P35241*ENSMUSG0000003205082
Ezr / Ezrin / P26040 / P15311*ENSMUSG0000005239773
Nf2 / P46662 / Merlin / P35240* / neurofibromin 2*ENSMUSG0000000907345
Farp1 / F8VPU2 / FERM, ARHGEF and pleckstrin domain-containing protein 1 / Q9Y4F1* / FERM, ARH/RhoGEF and pleckstrin domain protein 1*ENSMUSG0000002555526
Farp2 / Q91VS8 / FERM, ARHGEF and pleckstrin domain-containing protein 2 / O94887* / FERM, ARH/RhoGEF and pleckstrin domain protein 2*ENSMUSG0000003406625
Frmd7 / A2AD83 / FERM domain-containing protein 7 / Q6ZUT3* / FERM domain containing 7*ENSMUSG0000003613119
Mylip / Q8BM54 / E3 ubiquitin-protein ligase MYLIP / Q8WY64* / myosin regulatory light chain interacting protein*ENSMUSG0000003817516


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000798  Ezrin/radixin/moesin-like
 IPR008954  Moesin tail domain superfamily
 IPR011174  Ezrin/radixin/moesin
 IPR011259  Ezrin/radixin/moesin, C-terminal
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR035963  FERM superfamily, second domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001771 immunological synapse formation IEA
 biological_processGO:0007159 leukocyte cell-cell adhesion IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0008361 regulation of cell size IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0022612 gland morphogenesis IEA
 biological_processGO:0022614 membrane to membrane docking IEA
 biological_processGO:0042098 T cell proliferation IEA
 biological_processGO:0045198 establishment of epithelial cell apical/basal polarity IEA
 biological_processGO:0050900 leukocyte migration IEA
 biological_processGO:0061028 establishment of endothelial barrier IEA
 biological_processGO:0070489 T cell aggregation IEA
 biological_processGO:0071394 cellular response to testosterone stimulus IEA
 biological_processGO:0071803 positive regulation of podosome assembly IDA
 biological_processGO:0072678 T cell migration IEA
 biological_processGO:1902115 regulation of organelle assembly IEA
 biological_processGO:1902966 positive regulation of protein localization to early endosome IEA
 biological_processGO:1903364 positive regulation of cellular protein catabolic process IEA
 biological_processGO:2000401 regulation of lymphocyte migration IEA
 biological_processGO:2000643 positive regulation of early endosome to late endosome transport IEA
 cellular_componentGO:0001931 uropod IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0031143 pseudopodium IEA
 cellular_componentGO:0031528 microvillus membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0071437 invadopodium IEA
 cellular_componentGO:0071944 cell periphery IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA


Pathways (from Reactome)
Pathway description
Recycling pathway of L1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Irf2tm1Mak/Irf2tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Msntm1Sts/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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