ENSMUSG00000052397


Mus musculus

Features
Gene ID: ENSMUSG00000052397
  
Biological name :Ezr
  
Synonyms : Ezr / Ezrin / P26040
  
Possible biological names infered from orthology : P15311
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A1
Gene start: 6738041
Gene end: 6782784
  
Corresponding Affymetrix probe sets: 10447602 (MoGene1.0st)   1450850_at (Mouse Genome 430 2.0 Array)   1456725_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000063734
NCBI entrez gene - 22350     See in Manteia.
MGI - MGI:98931
RefSeq - NM_009510
RefSeq Peptide - NP_033536
swissprot - P26040
swissprot - Q4KML7
Ensembl - ENSMUSG00000052397
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ezraENSDARG00000020944Danio rerio
 ezrbENSDARG00000025091Danio rerio
 EZRENSG00000092820Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rdx / P26043 / radixin / P35241*ENSMUSG0000003205076
Msn / P26041 / Moesin / P26038*ENSMUSG0000003120772
Nf2 / P46662 / Merlin / P35240* / neurofibromin 2*ENSMUSG0000000907345
Farp1 / F8VPU2 / FERM, ARHGEF and pleckstrin domain-containing protein 1 / Q9Y4F1* / FERM, ARH/RhoGEF and pleckstrin domain protein 1*ENSMUSG0000002555525
Farp2 / Q91VS8 / FERM, ARHGEF and pleckstrin domain-containing protein 2 / O94887* / FERM, ARH/RhoGEF and pleckstrin domain protein 2*ENSMUSG0000003406625
Frmd7 / A2AD83 / FERM domain-containing protein 7 / Q6ZUT3* / FERM domain containing 7*ENSMUSG0000003613118
Mylip / Q8BM54 / E3 ubiquitin-protein ligase MYLIP / Q8WY64* / myosin regulatory light chain interacting protein*ENSMUSG0000003817516


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000798  Ezrin/radixin/moesin-like
 IPR008954  Moesin tail domain superfamily
 IPR011174  Ezrin/radixin/moesin
 IPR011259  Ezrin/radixin/moesin, C-terminal
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR035963  FERM superfamily, second domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001951 intestinal D-glucose absorption IGI
 biological_processGO:0003376 sphingosine-1-phosphate signaling pathway IEA
 biological_processGO:0007159 leukocyte cell-cell adhesion IEA
 biological_processGO:0008360 regulation of cell shape ISO
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010737 protein kinase A signaling IEA
 biological_processGO:0022614 membrane to membrane docking IEA
 biological_processGO:0030033 microvillus assembly IEA
 biological_processGO:0030855 epithelial cell differentiation IEA
 biological_processGO:0030953 astral microtubule organization IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0031623 receptor internalization IMP
 biological_processGO:0032532 regulation of microvillus length IGI
 biological_processGO:0034629 cellular protein-containing complex localization IEA
 biological_processGO:0035088 establishment or maintenance of apical/basal cell polarity IMP
 biological_processGO:0040018 positive regulation of multicellular organism growth IGI
 biological_processGO:0043622 cortical microtubule organization IEA
 biological_processGO:0046847 filopodium assembly IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:0050714 positive regulation of protein secretion IEA
 biological_processGO:0050860 negative regulation of T cell receptor signaling pathway IEA
 biological_processGO:0051017 actin filament bundle assembly IEA
 biological_processGO:0051660 establishment of centrosome localization IEA
 biological_processGO:0061028 establishment of endothelial barrier IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0072697 protein localization to cell cortex IEA
 biological_processGO:1900041 negative regulation of interleukin-2 secretion IEA
 biological_processGO:1902115 regulation of organelle assembly IEA
 biological_processGO:1902896 terminal web assembly IGI
 biological_processGO:1902966 positive regulation of protein localization to early endosome IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IGI
 biological_processGO:1903364 positive regulation of cellular protein catabolic process IEA
 biological_processGO:1903753 negative regulation of p38MAPK cascade IEA
 biological_processGO:2000643 positive regulation of early endosome to late endosome transport IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0001772 immunological synapse IEA
 cellular_componentGO:0001931 uropod IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0030315 T-tubule IEA
 cellular_componentGO:0031528 microvillus membrane IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0036064 ciliary basal body IDA
 cellular_componentGO:0042995 cell projection ISO
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0044393 microspike IEA
 cellular_componentGO:0044853 plasma membrane raft IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0051286 cell tip IEA
 cellular_componentGO:0071437 invadopodium IEA
 cellular_componentGO:0071944 cell periphery IEA
 cellular_componentGO:0097449 astrocyte projection IEA
 cellular_componentGO:0097454 Schwann cell microvillus IEA
 cellular_componentGO:0098592 cytoplasmic side of apical plasma membrane IEA
 molecular_functionGO:0003779 actin binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IDA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0034236 protein kinase A catalytic subunit binding IEA
 molecular_functionGO:0034237 protein kinase A regulatory subunit binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0044548 S100 protein binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA
 molecular_functionGO:0051015 actin filament binding IEA
 molecular_functionGO:0051018 protein kinase A binding IEA
 molecular_functionGO:0051117 ATPase binding IEA
 molecular_functionGO:0097718 disordered domain specific binding IDA


Pathways (from Reactome)
Pathway description
Netrin-1 signaling
Recycling pathway of L1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntrk1tm1Apat/Ntrk1tm1Apat
Genetic Background: involves: 129S1/Sv

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Snap25tm2.1(cre)Hze/Snap25+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Snap25tm2.1(cre)Hze/Snap25+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0004139 abnormal parietal cell morphology "malformation of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Snap25tm2.1(cre)Hze/Snap25+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0008003 achlorhydria "absence of hydrochloric acid in the gastric secretions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Snap25tm2.1(cre)Hze/Snap25+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0008109 abnormal small intestinal microvillus morphology "any structural anomaly of the additional extensions of the villi of the small intestine which protrude from the apical surface of the epithelial cells lining the villi; the microvilli increase the absorptive surface area of the small intestine by approximately 600-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Snap25tm2.1(cre)Hze/Snap25+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Cfl1tm1.1Wit/Cfl1tm1.1Wit
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ntrk1tm1Apat/Ntrk1tm1Apat
Genetic Background: involves: 129S1/Sv

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Snap25tm2.1(cre)Hze/Snap25+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026778 Prkcq / Q02111 / protein kinase C, theta / Q04759*  / reaction
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / reaction / complex
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / reaction / complex
 ENSMUSG00000060534 Dcc / P70211 / Netrin receptor DCC / P43146* / DCC netrin 1 receptor*  / reaction / complex






 

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