ENSDARG00000025091


Danio rerio

Features
Gene ID: ENSDARG00000025091
  
Biological name :sytl3
  
Synonyms : ezrb / synaptotagmin-like 3 / sytl3
  
Possible biological names infered from orthology : EZR / ezrin / P15311 / P26040
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 13564931
Gene end: 13625588
  
Corresponding Affymetrix probe sets: Dr.17071.1.A1_at (Zebrafish Array)   Dr.21433.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000063817
Ensembl peptide - ENSDARP00000073352
Ensembl peptide - ENSDARP00000126624
Ensembl peptide - ENSDARP00000126801
NCBI entrez gene - 561589     See in Manteia.
RefSeq - NM_001030285
RefSeq Peptide - NP_001025456
swissprot - Q5TZG5
swissprot - F1R321
swissprot - R4GE88
swissprot - R4GDR8
ZFIN ID - ZDB-GENE-040724-150
ZFIN ID - ZDB-GENE-050803-1
Ensembl - ENSDARG00000025091
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EZRENSGALG00000013742Gallus gallus
 EZRENSG00000092820Homo sapiens
 EzrENSMUSG00000052397Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ezra / ezrin a / EZR* / ezrin* / P15311* / P26040*ENSDARG0000002094480
msna / moesin a / MSN* / moesin* / P26038* / P26041*ENSDARG0000005812872
msnb / moesin b / MSN* / moesin* / P26038* / P26041*ENSDARG0000002874068
nf2a / neurofibromin 2a (merlin) / NF2* / P35240* / P46662* / Merlin * / neurofibromin 2*ENSDARG0000002020445
nf2b / neurofibromin 2b (merlin)ENSDARG0000002556743
farp2 / FERM, RhoGEF and pleckstrin domain protein 2 / O94887* / Q91VS8* / FERM, ARH/RhoGEF and pleckstrin domain protein 2* / FERM, ARHGEF and pleckstrin domain-containing protein 2 *ENSDARG0000001642924
farp1 / FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) / Q9Y4F1* / F8VPU2* / FERM, ARH/RhoGEF and pleckstrin domain protein 1* / FERM, ARHGEF and pleckstrin dom...ENSDARG0000007438124
frmd7 / FERM domain containing 7 / A2AD83* / Q6ZUT3* / FERM domain-containing protein 7 *ENSDARG0000006895815
mylipa / Q6TEM9 / myosin regulatory light chain interacting protein a / MYLIP* / Q8BM54* / Q8WY64* / E3 ubiquitin-protein ligase MYLIP * / myosin regulatory light chain interacting protein*ENSDARG0000000885914
mylipb / myosin regulatory light chain interacting protein b / MYLIP* / Q8BM54* / Q8WY64* / E3 ubiquitin-protein ligase MYLIP * / myosin regulatory light chain interacting protein*ENSDARG0000005511814
si:ch211-243g6.3 / FRMD7* / A2AD83* / Q6ZUT3* / FERM domain containing 7* / FERM domain-containing protein 7 *ENSDARG0000007049513
CABZ01066921.1ENSDARG0000011205611


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000798  Ezrin/radixin/moesin-like
 IPR008954  Moesin tail domain superfamily
 IPR011174  Ezrin/radixin/moesin
 IPR011259  Ezrin/radixin/moesin, C-terminal
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0035850 epithelial cell differentiation involved in kidney development IMP
 biological_processGO:0042074 cell migration involved in gastrulation IMP
 biological_processGO:0060271 cilium assembly IGI
 biological_processGO:0090504 epiboly IMP
 biological_processGO:1902017 regulation of cilium assembly IMP
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0017137 Rab GTPase binding IEA


Pathways (from Reactome)
Pathway description
Netrin-1 signaling
Recycling pathway of L1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000004 anterior axial hypoblast anterior axial hypoblast lamellipodium decreased amount , abnormal
anterior axial hypoblast filopodium decreased amount , abnormal
anterior axial hypoblast bleb increased amount , abnormal
anterior axial hypoblast bleb increased size , abnormal
anterior axial hypoblast decreased cellular motility , abnormal
Show

 ZFA:0000008 brain brain hydrocephalic , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct has fewer parts of type pronephric duct motile cilium, abnormal
pronephric duct 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate mislocalised , abnormal
pronephric duct 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate mislocalised , abnormal
pronephric duct apical plasma membrane mislocalised , abnormal
pronephric duct filamentous actin mislocalised , abnormal
pronephric duct ciliary basal body mislocalised , abnormal
pronephric duct cilium assembly decreased occurrence , abnormal
pronephric duct actin filament bundle distribution decreased process quality , abnormal
pronephric duct ciliary basal body-plasma membrane docking decreased process quality , abnormal
Show

 ZFA:0000151 pronephros pronephros cystic , abnormal
pronephros cilium assembly decreased process quality , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved ventral , abnormal
Show

 ZFA:0001176 blastoderm blastoderm increased thickness , abnormal
Show

 ZFA:0001557 pronephric glomerulus pronephric glomerulus cystic , abnormal
Show

 ZFA:0001558 pronephric tubule pronephric tubule has fewer parts of type pronephric tubule microvillus, abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr