ENSG00000092820


Homo sapiens

Features
Gene ID: ENSG00000092820
  
Biological name :EZR
  
Synonyms : EZR / ezrin / P15311
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q25.3
Gene start: 158765741
Gene end: 158819412
  
Corresponding Affymetrix probe sets: 208621_s_at (Human Genome U133 Plus 2.0 Array)   208622_s_at (Human Genome U133 Plus 2.0 Array)   208623_s_at (Human Genome U133 Plus 2.0 Array)   217230_at (Human Genome U133 Plus 2.0 Array)   217234_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000376016
Ensembl peptide - ENSP00000338934
Ensembl peptide - ENSP00000356042
NCBI entrez gene - 7430     See in Manteia.
OMIM - 123900
RefSeq - XM_011536110
RefSeq - NM_001111077
RefSeq - NM_003379
RefSeq Peptide - NP_001104547
RefSeq Peptide - NP_003370
swissprot - P15311
swissprot - E7EQR4
Ensembl - ENSG00000092820
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ezraENSDARG00000020944Danio rerio
 ezrbENSDARG00000025091Danio rerio
 EzrENSMUSG00000052397Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RDX / P35241 / radixinENSG0000013771077
MSN / moesin / P26038ENSG0000014706573
NF2 / P35240 / neurofibromin 2ENSG0000018657546
FARP1 / Q9Y4F1 / FERM, ARH/RhoGEF and pleckstrin domain protein 1ENSG0000015276725
FARP2 / O94887 / FERM, ARH/RhoGEF and pleckstrin domain protein 2ENSG0000000660725
FRMD7 / Q6ZUT3 / FERM domain containing 7ENSG0000016569419
MYLIP / Q8WY64 / myosin regulatory light chain interacting proteinENSG0000000794416


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000798  Ezrin/radixin/moesin-like
 IPR008954  Moesin tail domain superfamily
 IPR011174  Ezrin/radixin/moesin
 IPR011259  Ezrin/radixin/moesin, C-terminal
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR035963  FERM superfamily, second domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001951 intestinal D-glucose absorption IEA
 biological_processGO:0003376 sphingosine-1-phosphate signaling pathway IMP
 biological_processGO:0007016 cytoskeletal anchoring at plasma membrane NAS
 biological_processGO:0007159 leukocyte cell-cell adhesion IEP
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0010628 positive regulation of gene expression IGI
 biological_processGO:0010737 protein kinase A signaling IMP
 biological_processGO:0022614 membrane to membrane docking IEP
 biological_processGO:0030033 microvillus assembly IMP
 biological_processGO:0030855 epithelial cell differentiation IEA
 biological_processGO:0030953 astral microtubule organization IMP
 biological_processGO:0031532 actin cytoskeleton reorganization IMP
 biological_processGO:0031623 receptor internalization IEA
 biological_processGO:0032532 regulation of microvillus length IEA
 biological_processGO:0034629 cellular protein-containing complex localization IMP
 biological_processGO:0035088 establishment or maintenance of apical/basal cell polarity IEA
 biological_processGO:0040018 positive regulation of multicellular organism growth IEA
 biological_processGO:0043622 cortical microtubule organization IMP
 biological_processGO:0046847 filopodium assembly IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IDA
 biological_processGO:0050714 positive regulation of protein secretion IMP
 biological_processGO:0050860 negative regulation of T cell receptor signaling pathway IMP
 biological_processGO:0051017 actin filament bundle assembly IDA
 biological_processGO:0051660 establishment of centrosome localization IMP
 biological_processGO:0061028 establishment of endothelial barrier IGI
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0071320 cellular response to cAMP IMP
 biological_processGO:0072659 protein localization to plasma membrane IMP
 biological_processGO:0072697 protein localization to cell cortex IMP
 biological_processGO:1900041 negative regulation of interleukin-2 secretion IMP
 biological_processGO:1902115 regulation of organelle assembly IMP
 biological_processGO:1902896 terminal web assembly IEA
 biological_processGO:1902966 positive regulation of protein localization to early endosome IGI
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:1903364 positive regulation of cellular protein catabolic process IGI
 biological_processGO:1903753 negative regulation of p38MAPK cascade IMP
 biological_processGO:2000643 positive regulation of early endosome to late endosome transport IMP
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0001726 ruffle IDA
 cellular_componentGO:0001772 immunological synapse IDA
 cellular_componentGO:0001931 uropod IEA
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005902 microvillus IDA
 cellular_componentGO:0005903 brush border IEA
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane IDA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0030315 T-tubule IEA
 cellular_componentGO:0030863 cortical cytoskeleton TAS
 cellular_componentGO:0031528 microvillus membrane IEA
 cellular_componentGO:0031982 vesicle HDA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0036064 ciliary basal body IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0044393 microspike IEA
 cellular_componentGO:0044853 plasma membrane raft IDA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0051286 cell tip IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071437 invadopodium IDA
 cellular_componentGO:0071944 cell periphery IDA
 cellular_componentGO:0097449 astrocyte projection IEA
 cellular_componentGO:0097454 Schwann cell microvillus IEA
 cellular_componentGO:0098592 cytoplasmic side of apical plasma membrane IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IMP
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0034236 protein kinase A catalytic subunit binding IPI
 molecular_functionGO:0034237 protein kinase A regulatory subunit binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0044548 S100 protein binding IPI
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0050839 cell adhesion molecule binding IPI
 molecular_functionGO:0051015 actin filament binding IDA
 molecular_functionGO:0051018 protein kinase A binding IPI
 molecular_functionGO:0051117 ATPase binding IPI
 molecular_functionGO:0097718 disordered domain specific binding IEA


Pathways (from Reactome)
Pathway description
Netrin-1 signaling
Recycling pathway of L1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000065675 PRKCQ / Q04759 / protein kinase C theta  / reaction
 ENSG00000187323 DCC / P43146 / DCC netrin 1 receptor  / reaction / complex
 ENSG00000198910 L1CAM / P32004 / L1 cell adhesion molecule  / reaction / complex
 ENSG00000184009 ACTG1 / P63261 / actin gamma 1  / complex / reaction
 ENSG00000075624 ACTB / P60709 / actin beta  / reaction / complex






 

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