ENSMUSG00000034066


Mus musculus

Features
Gene ID: ENSMUSG00000034066
  
Biological name :Farp2
  
Synonyms : Farp2 / FERM, ARHGEF and pleckstrin domain-containing protein 2 / Q91VS8
  
Possible biological names infered from orthology : FERM, ARH/RhoGEF and pleckstrin domain protein 2 / O94887
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: D
Gene start: 93512079
Gene end: 93621976
  
Corresponding Affymetrix probe sets: 10348829 (MoGene1.0st)   1424583_at (Mouse Genome 430 2.0 Array)   1440799_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113790
Ensembl peptide - ENSMUSP00000112725
NCBI entrez gene - 227377     See in Manteia.
MGI - MGI:2385126
RefSeq - NM_145519
RefSeq Peptide - NP_663494
swissprot - D3Z4C0
swissprot - Q91VS8
Ensembl - ENSMUSG00000034066
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 farp2ENSDARG00000016429Danio rerio
 FARP2ENSGALG00000005788Gallus gallus
 FARP2ENSG00000006607Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Farp1 / F8VPU2 / FERM, ARHGEF and pleckstrin domain-containing protein 1 / Q9Y4F1* / FERM, ARH/RhoGEF and pleckstrin domain protein 1*ENSMUSG0000002555552
Frmd7 / A2AD83 / FERM domain-containing protein 7 / Q6ZUT3* / FERM domain containing 7*ENSMUSG0000003613124
Rdx / P26043 / radixin / P35241*ENSMUSG0000003205015
Ezr / Ezrin / P26040 / P15311*ENSMUSG0000005239714
Msn / P26041 / Moesin / P26038*ENSMUSG0000003120714
Nf2 / P46662 / Merlin / P35240* / neurofibromin 2*ENSMUSG0000000907312
Mylip / Q8BM54 / E3 ubiquitin-protein ligase MYLIP / Q8WY64* / myosin regulatory light chain interacting protein*ENSMUSG0000003817511


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000299  FERM domain
 IPR000798  Ezrin/radixin/moesin-like
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR014847  FERM adjacent (FA)
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily
 IPR035963  FERM superfamily, second domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IMP
 biological_processGO:0016322 neuron remodeling IEA
 biological_processGO:0016601 Rac protein signal transduction IEA
 biological_processGO:0022405 hair cycle process IMP
 biological_processGO:0030316 osteoclast differentiation IMP
 biological_processGO:0031532 actin cytoskeleton reorganization IMP
 biological_processGO:0033623 regulation of integrin activation IMP
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IMP
 biological_processGO:0071800 podosome assembly IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity ISO
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity TAS


Pathways (from Reactome)
Pathway description
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Gata1tm6Sho/Gata1tm6Sho
Genetic Background: involves: 129S1/Sv * BALB/c

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata1tm6Sho/Gata1tm6Sho
Genetic Background: involves: 129S1/Sv * BALB/c

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata1tm6Sho/Gata1tm6Sho
Genetic Background: involves: 129S1/Sv * BALB/c

 MP:0004993 decreased bone resorption "reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata1tm6Sho/Gata1tm6Sho
Genetic Background: involves: 129S1/Sv * BALB/c

 MP:0010867 abnormal bone trabecula morphology "any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata1tm6Sho/Gata1tm6Sho
Genetic Background: involves: 129S1/Sv * BALB/c

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata1tm6Sho/Gata1tm6Sho
Genetic Background: involves: 129S1/Sv * BALB/c

 MP:0010877 abnormal trabecular bone volume "any anomaly in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata1tm6Sho/Gata1tm6Sho
Genetic Background: involves: 129S1/Sv * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031398 P70208 / Plxna3 / plexin A3 / P51805*  / complex
 ENSMUSG00000026640 P70207 / Plxna2 / Plexin-A2 / O75051*  / complex
 ENSMUSG00000025810 Nrp1 / P97333 / Neuropilin-1 / O14786*  / complex / reaction
 ENSMUSG00000028465 Tln1 / P26039 / talin 1 / Q9Y490*  / reaction
 ENSMUSG00000028883 O08665 / Sema3a / Semaphorin-3A / Q14563*  / reaction
 ENSMUSG00000030084 P70206 / Plxna1 / Plexin-A1 / Q9UIW2*  / reaction / complex
 ENSMUSG00000034902 O70161 / Pip5k1c / Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma / O60331*  / reaction / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSMUSG00000029765 Plxna4 / Q80UG2 / plexin A4 / Q9HCM2*  / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction






 

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