ENSMUSG00000029765


Mus musculus

Features
Gene ID: ENSMUSG00000029765
  
Biological name :Plxna4
  
Synonyms : plexin A4 / Plxna4 / Q80UG2
  
Possible biological names infered from orthology : Q9HCM2
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: A3.3
Gene start: 32144268
Gene end: 32588192
  
Corresponding Affymetrix probe sets: 10543802 (MoGene1.0st)   1441371_at (Mouse Genome 430 2.0 Array)   1457840_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110748
NCBI entrez gene - 243743     See in Manteia.
MGI - MGI:2179061
RefSeq - NM_175750
RefSeq Peptide - NP_786926
swissprot - Q80UG2
Ensembl - ENSMUSG00000029765
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plxna4ENSDARG00000019328Danio rerio
 PLXNA4ENSGALG00000006473Gallus gallus
 PLXNA4ENSG00000221866Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P70207 / Plxna2 / Plexin-A2 / O75051*ENSMUSG0000002664067
P70206 / Plxna1 / Plexin-A1 / Q9UIW2*ENSMUSG0000003008463
P70208 / Plxna3 / plexin A3 / P51805*ENSMUSG0000003139859
Plxnb1 / Q8CJH3 / plexin B1 / O43157*ENSMUSG0000005364634
Plxnb3 / Q9QY40 / Plexin-B3 / Q9ULL4*ENSMUSG0000003138533
B2RXS4 / Plxnb2 / plexin B2 / O15031*ENSMUSG0000003660631
Plxnd1 / Q3UH93 / plexin D1 / Q9Y4D7*ENSMUSG0000003012331
Plxnc1 / Q9QZC2 / Plexin-C1 / O60486*ENSMUSG0000007478521


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR002909  IPT domain
 IPR008936  Rho GTPase activation protein
 IPR013548  Plexin, cytoplasmic RasGAP domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR031148  Plexin family
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007399 nervous system development IGI
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0008045 motor neuron axon guidance IMP
 biological_processGO:0021602 cranial nerve morphogenesis IMP
 biological_processGO:0021610 facial nerve morphogenesis IMP
 biological_processGO:0021612 facial nerve structural organization IMP
 biological_processGO:0021615 glossopharyngeal nerve morphogenesis IMP
 biological_processGO:0021636 trigeminal nerve morphogenesis IMP
 biological_processGO:0021637 trigeminal nerve structural organization IMP
 biological_processGO:0021644 vagus nerve morphogenesis IMP
 biological_processGO:0021784 postganglionic parasympathetic fiber development IMP
 biological_processGO:0021785 branchiomotor neuron axon guidance IMP
 biological_processGO:0021793 chemorepulsion of branchiomotor axon IMP
 biological_processGO:0021960 anterior commissure morphogenesis IMP
 biological_processGO:0048485 sympathetic nervous system development IMP
 biological_processGO:0048812 neuron projection morphogenesis IMP
 biological_processGO:0048841 regulation of axon extension involved in axon guidance IMP
 biological_processGO:0050923 regulation of negative chemotaxis IMP
 biological_processGO:0071526 semaphorin-plexin signaling pathway IMP
 biological_processGO:1902287 semaphorin-plexin signaling pathway involved in axon guidance IMP
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017154 semaphorin receptor activity IGI


Pathways (from Reactome)
Pathway description
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000861 disorganized barrel cortex "derangement of the pattern of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae" [Principles of Neural Science:ISBN 0-8385-8034-3, J:64064]
Show

Allelic Composition: Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0000966 reduced sensory neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Adora1tm1Bbf/Adora1tm1Bbf
Genetic Background: B6.129P2-Adora1tm1Bbf

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
Show

Allelic Composition: Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

Allelic Composition: Plxna3tm1Matl/Plxna3tm1Matl,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0001056 abnormal cranial nerve morphology "any anomaly, deformity, or malformation of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
Show

Allelic Composition: Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001063 abnormal trochlear nerve morphology "any malformation or misprojection of the 4th cranial nerve, which normally carries the motor innervation of the superior oblique muscles of the eye " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

Allelic Composition: Plxna3tm1Matl/Plxna3tm1Matl,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
Show

Allelic Composition: Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

Allelic Composition: Plxna3tm1Matl/Plxna3tm1Matl,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0001071 abnormal facial nerve morphology "malformed or misprojection of motor axons from the pons to the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
Show

Allelic Composition: Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001073 abnormal glossopharyngeal nerve morphology "malformed or misprojection of sensory and autonomic axons to the parotid gland, carotid body, posterior third of the tongue" [Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
Show

Allelic Composition: Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001074 abnormal vagus nerve morphology "malformed or misprojection of autonomic, sensory and motor axons of the tenth cranial nerve to the pharynx, larynx, trachea, lungs, heart and GI tract" [Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
Show

Allelic Composition: Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001077 abnormal spinal nerve morphology "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Plxna4tm1Hfu/Plxna4+
Genetic Background: B6.Cg-Plxna4tm1Hfu

 MP:0002761 abnormal hippocampal mossy fiber morphology "absence or misprojection of axons of neuronal cells in the dentate gyrus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:4978]
Show

Allelic Composition: Celsr3tm1Agof/Celsr3tm2Agof,Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu,Plxna4tm1Hfu/Plxna4tm1Hfu
Genetic Background: involves: C57BL/6 * CBA

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Plxna4tm1Hfu/Plxna4+
Genetic Background: B6.Cg-Plxna4tm1Hfu

Allelic Composition: Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

Allelic Composition: Plxna3tm1Matl/Plxna3tm1Matl,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0005240 abnormal amacrine cell morphology "anomalous structure of the interneurons of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Adora1tm1Bbf/Adora1tm1Bbf
Genetic Background: B6.129P2-Adora1tm1Bbf

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adora1tm1Bbf/Adora1tm1Bbf
Genetic Background: B6.129P2-Adora1tm1Bbf

 MP:0008225 abnormal anterior commissure morphology "any structural anomaly of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Plxna4tm1Hfu/Plxna4+
Genetic Background: B6.Cg-Plxna4tm1Hfu

 MP:0008226 decreased anterior commissure size "reduced size of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0008312 abnormal sympathetic postganglionic fiber "any structural anomaly of any or all of the noradrenergic and some adrenergic axonal fibers projecting from a sympathetic ganglion to an effector organ" [MESH:A08.663.542.075.800, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
Show

Allelic Composition: Adora1tm1Bbf/Adora1tm1Bbf
Genetic Background: B6.129P2-Adora1tm1Bbf

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Celsr3tm1Agof/Celsr3tm2Agof,Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010859 abnormal anterior commissure pars anterior morphology "any structural anomaly of the small horseshoe-shaped anterior part of the anterior commissure which pass into the two olfactory bulbs" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Plxna4tm1Hfu/Plxna4+
Genetic Background: B6.Cg-Plxna4tm1Hfu

 MP:0010860 abnormal anterior commissure pars posterior morphology "any structural anomaly of the large posterior part of the anterior commissure which connects the right and left temporal lobes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Plxna4tm1Hfu/Plxna4+
Genetic Background: B6.Cg-Plxna4tm1Hfu

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022812 Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*  / reaction
 ENSMUSG00000025810 Nrp1 / P97333 / Neuropilin-1 / O14786*  / complex
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / complex / reaction
 ENSMUSG00000028969 Cdk5 / P49615 / Cyclin-dependent-like kinase 5 / Q00535* / cyclin dependent kinase 5*  / complex
 ENSMUSG00000028883 O08665 / Sema3a / Semaphorin-3A / Q14563*  / complex / reaction
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / complex / reaction
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / complex / reaction
 ENSMUSG00000048895 Cdk5r1 / P61809 / Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 activator 1, p35 Cyclin-dependent kinase 5 activator 1, p25 / Q15078* / cyclin dependent kinase 5 regulator...  / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / complex
 ENSMUSG00000053158 Fes / P16879 / Tyrosine-protein kinase Fes/Fps / P07332* / FES proto-oncogene, tyrosine kinase*  / complex
 ENSMUSG00000034066 Farp2 / Q91VS8 / FERM, ARHGEF and pleckstrin domain-containing protein 2 / O94887* / FERM, ARH/RhoGEF and pleckstrin domain protein 2*  / complex
 ENSMUSG00000019647 O35464 / Sema6a / Semaphorin-6A / Q9H2E6*  / reaction / complex






 

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