ENSMUSG00000022812


Mus musculus

Features
Gene ID: ENSMUSG00000022812
  
Biological name :Gsk3b
  
Synonyms : glycogen synthase kinase 3 beta / Gsk3b / Q9WV60
  
Possible biological names infered from orthology : P49841
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B3
Gene start: 38089001
Gene end: 38246084
  
Corresponding Affymetrix probe sets: 10435676 (MoGene1.0st)   1434439_at (Mouse Genome 430 2.0 Array)   1437001_at (Mouse Genome 430 2.0 Array)   1439931_at (Mouse Genome 430 2.0 Array)   1439949_at (Mouse Genome 430 2.0 Array)   1451020_at (Mouse Genome 430 2.0 Array)   1454958_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023507
Ensembl peptide - ENSMUSP00000110398
NCBI entrez gene - 56637     See in Manteia.
MGI - MGI:1861437
RefSeq - XM_006522426
RefSeq - NM_019827
RefSeq - XM_006522425
RefSeq Peptide - NP_062801
RefSeq Peptide - NP_001334161
swissprot - Q5KU03
swissprot - Q9WV60
swissprot - E9QAQ5
Ensembl - ENSMUSG00000022812
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gsk3bENSDARG00000017803Danio rerio
 si:dkeyp-80c12.7ENSDARG00000052468Danio rerio
 GSK3BENSGALG00000014977Gallus gallus
 GSK3BENSG00000082701Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gsk3a / Q2NL51 / Glycogen synthase kinase-3 alpha / P49840*ENSMUSG0000005717773


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033573  Glycogen synthase kinase-3 beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000320 re-entry into mitotic cell cycle IDA
 biological_processGO:0001837 epithelial to mesenchymal transition IEA
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IEA
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0005977 glycogen metabolic process IEA
 biological_processGO:0006349 regulation of gene expression by genetic imprinting IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006611 protein export from nucleus IDA
 biological_processGO:0006983 ER overload response IEA
 biological_processGO:0007010 cytoskeleton organization TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007409 axonogenesis IGI
 biological_processGO:0007520 myoblast fusion IGI
 biological_processGO:0007623 circadian rhythm IMP
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008286 insulin receptor signaling pathway IDA
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0010508 positive regulation of autophagy IGI
 biological_processGO:0010614 negative regulation of cardiac muscle hypertrophy IDA
 biological_processGO:0010628 positive regulation of gene expression IGI
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IDA
 biological_processGO:0010822 positive regulation of mitochondrion organization IEA
 biological_processGO:0010975 regulation of neuron projection development IGI
 biological_processGO:0010977 negative regulation of neuron projection development IMP
 biological_processGO:0014043 negative regulation of neuron maturation IGI
 biological_processGO:0014902 myotube differentiation IGI
 biological_processGO:0016055 Wnt signaling pathway IGI
 biological_processGO:0016310 phosphorylation IMP
 biological_processGO:0016477 cell migration IGI
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0031333 negative regulation of protein complex assembly IEA
 biological_processGO:0031334 positive regulation of protein complex assembly IEA
 biological_processGO:0032007 negative regulation of TOR signaling IGI
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032092 positive regulation of protein binding IDA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032886 regulation of microtubule-based process IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0035372 protein localization to microtubule IGI
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IDA
 biological_processGO:0036016 cellular response to interleukin-3 IDA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0044027 hypermethylation of CpG island IMP
 biological_processGO:0044337 canonical Wnt signaling pathway involved in positive regulation of apoptotic process IMP
 biological_processGO:0045444 fat cell differentiation IDA
 biological_processGO:0045773 positive regulation of axon extension IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0046827 positive regulation of protein export from nucleus IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IEA
 biological_processGO:0071109 superior temporal gyrus development IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IGI
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IDA
 biological_processGO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IDA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1904780 negative regulation of protein localization to centrosome IMP
 biological_processGO:1904781 positive regulation of protein localization to centrosome IEA
 biological_processGO:2000727 positive regulation of cardiac muscle cell differentiation IMP
 biological_processGO:2000738 positive regulation of stem cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane ISS
 cellular_componentGO:0030426 growth cone IDA
 cellular_componentGO:0030877 beta-catenin destruction complex IEA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0043198 dendritic shaft IDA
 cellular_componentGO:0043227 membrane-bounded organelle IDA
 cellular_componentGO:0044297 cell body IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:1990909 Wnt signalosome IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0034236 protein kinase A catalytic subunit binding IEA
 molecular_functionGO:0034452 dynactin binding IEA
 molecular_functionGO:0050321 tau-protein kinase activity IEA
 molecular_functionGO:0051059 NF-kappaB binding IEA
 molecular_functionGO:0070840 dynein complex binding IPI


Pathways (from Reactome)
Pathway description
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Regulation of HSF1-mediated heat shock response
CRMPs in Sema3A signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
B-WICH complex positively regulates rRNA expression
GLI3 is processed to GLI3R by the proteasome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Ptf1atm1(cre)Hnak/Ptf1atm1(cre)Hnak
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Gsk3btm1Grc/Gsk3btm1Jrw
Genetic Background: involves: 129 * 129S6/SvEvTac * CD-1

Allelic Composition: Gsk3btm1Jrw/Gsk3btm1Jrw
Genetic Background: involves: 129 * CD-1

 MP:0000084 abnormal fontanelle morphology "structural defect in the membranous interval at the margins of cranial bones in neonates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Gsk3btm1Jrw/Gsk3b+,Runx2tm1Kish/Runx2+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Gsk3atm1a(EUCOMM)Wtsi/Gsk3a+,Gsk3btm1Grc/Gsk3btm1Grc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

Allelic Composition: Gsk3atm1a(EUCOMM)Wtsi/Gsk3a+,Gsk3btm1Grc/Gsk3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Insrtm1Dac/Insr+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Gsk3btm1Jrw/Gsk3b+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gsk3btm2Jrw/Gsk3btm2Jrw,Irs2tm1Mfw/Irs2tm1Mfw,Tg(Ins2-cre)23Herr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000540 abnormal urinary bladder epithelium morphology "malformation of the epithelial layer of the urinary bladder" [MGI:tc]
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Allelic Composition: Apctm1Tno/Apctm1Tno,Gsk3atm1Jrw/Gsk3atm1Jrw,Gsk3btm2Jrw/Gsk3btm2Jrw
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Fgf8tm1.2Mrt/Fgf8tm1.4Mrt
Genetic Background: involves: 129P2/OlaHsd

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fgf8tm1.2Mrt/Fgf8tm1.4Mrt
Genetic Background: involves: 129P2/OlaHsd

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001413 abnormal response to new environment "altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Adarb1tm1.1Eme/Adarb1tm1.1Eme
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ednrbs/Ednrbs-1Pu
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Insrtm1Dac/Insr+
Genetic Background: involves: 129 * C57BL/6J

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001898 abnormal long term depression "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adarb1tm1.1Eme/Adarb1tm1.1Eme
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gsk3btm1Jrw/Gsk3b+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gsk3btm2Jrw/Gsk3btm2Jrw,Irs2tm1Mfw/Irs2tm1Mfw,Tg(Ins2-cre)23Herr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adarb1tm1.1Eme/Adarb1tm1.1Eme
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ksr2tm2.1Lex/Ksr2tm2.1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002999 abnormal bone healing "defects in the restoration of integrity to bone after trauma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Adarb1tm1.1Eme/Adarb1tm1.1Eme
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003037 increased infarction size "increased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Khdrbs2Tg(LRRK2*R1441G)135Cjli/Khdrbs2+
Genetic Background: FVB/N-Khdrbs2Tg(LRRK2*R1441G)135Cjli/J

Allelic Composition: Gsk3btm1Grc/Gsk3b+
Genetic Background: involves: 129S6/SvEvTac

 MP:0003038 decreased infarction size "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Khdrbs2Tg(LRRK2*R1441G)135Cjli/Khdrbs2+
Genetic Background: FVB/N-Khdrbs2Tg(LRRK2*R1441G)135Cjli/J

Allelic Composition: Gsk3btm1Grc/Gsk3b+
Genetic Background: involves: 129S6/SvEvTac

 MP:0003064 decreased coping response "reduced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]
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Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004148 increased cortical bone thickness "thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Ednrbs/Ednrbs-1Pu
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0004320 split sternum "the appearance of an abnormal division in the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Ptf1atm1(cre)Hnak/Ptf1atm1(cre)Hnak
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Gsk3btm1Grc/Gsk3btm1Jrw
Genetic Background: involves: 129 * 129S6/SvEvTac * CD-1

Allelic Composition: Gsk3btm1Jrw/Gsk3btm1Jrw
Genetic Background: involves: 129 * CD-1

 MP:0004679 xiphoid process foramen "the appearance of a hole or holes in the posterior tip of the sternum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Ptf1atm1(cre)Hnak/Ptf1atm1(cre)Hnak
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Gsk3btm1Grc/Gsk3btm1Jrw
Genetic Background: involves: 129 * 129S6/SvEvTac * CD-1

Allelic Composition: Gsk3btm1Jrw/Gsk3btm1Jrw
Genetic Background: involves: 129 * CD-1

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ksr2tm2.1Lex/Ksr2tm2.1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ednrbs/Ednrbs-1Pu
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ednrbs/Ednrbs-1Pu
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Insrtm1Dac/Insr+
Genetic Background: involves: 129 * C57BL/6J

 MP:0005298 abnormal clavicle morphology "malformation of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gsk3btm1Jrw/Gsk3b+,Runx2tm1Kish/Runx2+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Dac/Insr+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Gsk3btm1Jrw/Gsk3b+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005438 abnormal glycogen homeostasis "abnormal processing and or utilization of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gsk3atm1Dral/Gsk3atm1Dral,Gsk3btm1Dral/Gsk3btm1Dral,Gys1tm1.1Arte/Gys1tm1.1Arte
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005440 increased glycogen level "greater than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ksr2tm2.1Lex/Ksr2tm2.1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Gsk3btm1Jrw/Gsk3b+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ednrbs/Ednrbs-1Pu
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Ptf1atm1(cre)Hnak/Ptf1atm1(cre)Hnak
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Gsk3btm1Grc/Gsk3btm1Jrw
Genetic Background: involves: 129 * 129S6/SvEvTac * CD-1

Allelic Composition: Gsk3btm1Jrw/Gsk3btm1Jrw
Genetic Background: involves: 129 * CD-1

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adarb1tm1.1Eme/Adarb1tm1.1Eme
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009114 decreased pancreatic beta cell mass "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gsk3btm1Jrw/Gsk3b+,Insrtm1Dac/Insr+
Genetic Background: involves: 129 * C57BL/6J

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009455 enhanced cued conditioning behavior "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009488 pancreatic islet cell apoptosis "change in the timing or the number of pancreatic islet cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gsk3btm1Jrw/Gsk3b+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009653 abnormal palate development "abnormal formation of the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0009745 abnormal behavioral response to xenobiotic "any anomaly in the behavioral response induced by a foreign compound, such as consumption preference, induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009885 abnormal palatal shelf elevation "any anomaly in the process in which the palatal shelves move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
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Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Ptf1atm1(cre)Hnak/Ptf1atm1(cre)Hnak
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Gsk3btm1Grc/Gsk3btm1Jrw
Genetic Background: involves: 129 * 129S6/SvEvTac * CD-1

Allelic Composition: Gsk3btm1Jrw/Gsk3btm1Jrw
Genetic Background: involves: 129 * CD-1

Allelic Composition: Gsk3btm1.2Ypc/Gsk3btm1.2Ypc
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Ptf1atm1(cre)Hnak/Ptf1atm1(cre)Hnak
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Gsk3btm1Grc/Gsk3btm1Jrw
Genetic Background: involves: 129 * 129S6/SvEvTac * CD-1

Allelic Composition: Gsk3btm1Jrw/Gsk3btm1Jrw
Genetic Background: involves: 129 * CD-1

Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0010400 increased liver glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010653 abnormal Wallerian degeneration "any anomaly in the process of progressive degeneration of axons distal to an injury" [PMID:20345246]
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Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0010872 increased trabecular bone mass "greater total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ednrbs/Ednrbs-1Pu
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ednrbs/Ednrbs-1Pu
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Gsk3btm1.1Atak/Gsk3b+
Genetic Background: involves: C57BL/6

 MP:0010961 increased compact bone mass 
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Allelic Composition: Ednrbs/Ednrbs-1Pu
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0010964 increased compact bone volume 
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Allelic Composition: Gsk3btm1.1Atak/Gsk3b+
Genetic Background: involves: C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Ptf1atm1(cre)Hnak/Ptf1atm1(cre)Hnak
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Gsk3btm1Grc/Gsk3btm1Jrw
Genetic Background: involves: 129 * 129S6/SvEvTac * CD-1

Allelic Composition: Gsk3btm1Jrw/Gsk3btm1Jrw
Genetic Background: involves: 129 * CD-1

Allelic Composition: Gsk3btm1.2Ypc/Gsk3btm1.2Ypc
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Fgf8tm1.2Mrt/Fgf8tm1.4Mrt
Genetic Background: involves: 129P2/OlaHsd

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

 MP:0011710 increased osteoblast differentiation 
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Allelic Composition: Ednrbs/Ednrbs-1Pu
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0011819 increased pancreatic beta cell proliferation "increase in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
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Allelic Composition: Gsk3btm1Jrw/Gsk3b+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0020039 increased bone ossification "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Ednrbs/Ednrbs-1Pu
Genetic Background: involves: 101/Rl * C3H/Rl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003233 Dvl3 / Q61062 / Segment polarity DVL-3 / Q92997* / dishevelled segment polarity protein 3*  / complex / reaction
 ENSMUSG00000009900 Wnt3a / P27467 / wingless-type MMTV integration site family, member 3A / P56704* / Wnt family member 3A*  / complex / reaction
 ENSMUSG00000012282 Wnt8a / Q64527 / wingless-type MMTV integration site family, member 8A / Q9H1J5* / Wnt family member 8A*  / complex / reaction
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / complex / reaction
 ENSMUSG00000024182 Axin1 / O15169*  / complex
 ENSMUSG00000047604 Frat2 / Q8K025 / GSK-3-binding protein FRAT2 / O75474* / FRAT2, WNT signaling pathway regulator*  / reaction / complex
 ENSMUSG00000021318 Gli3 / Q61602 / Transcriptional activator GLI3 Transcriptional repressor GLI3R / P10071* / GLI family zinc finger 3*  / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / reaction
 ENSMUSG00000039153 Runx2 / Q08775 / runt related transcription factor 2 / Q13950*  / complex
 ENSMUSG00000025810 Nrp1 / P97333 / Neuropilin-1 / O14786*  / reaction
 ENSMUSG00000028883 O08665 / Sema3a / Semaphorin-3A / Q14563*  / reaction
 ENSMUSG00000028969 Cdk5 / P49615 / Cyclin-dependent-like kinase 5 / Q00535* / cyclin dependent kinase 5*  / reaction
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / complex / reaction
 ENSMUSG00000031398 P70208 / Plxna3 / plexin A3 / P51805*  / reaction
 ENSMUSG00000028086 Fbxw7 / Q8VBV4 / F-box/WD repeat-containing protein 7 / Q969H0* / F-box and WD repeat domain containing 7*  / complex / reaction
 ENSMUSG00000048895 Cdk5r1 / P61809 / Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 activator 1, p35 Cyclin-dependent kinase 5 activator 1, p25 / Q15078* / cyclin dependent kinase 5 regulator...  / reaction
 ENSMUSG00000006728 Cdk4 / P30285 / Cyclin-dependent kinase 4 / P11802*  / reaction
 ENSMUSG00000070526 Peg12 / FRAT1* / Q92837* / FRAT1, WNT signaling pathway regulator*  / reaction / complex
 ENSMUSG00000025231 Sufu / Q9Z0P7 / SUFU negative regulator of hedgehog signaling / Q9UMX1*  / reaction
 ENSMUSG00000030084 P70206 / Plxna1 / Plexin-A1 / Q9UIW2*  / reaction
 ENSMUSG00000022556 Hsf1 / P38532 / heat shock factor 1 / Q00613* / heat shock transcription factor 1*  / reaction
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex / reaction
 ENSMUSG00000067199 Frat1 / P70339 / Proto-onco FRAT1 / Q92837* / FRAT1, WNT signaling pathway regulator*  / complex / reaction
 ENSMUSG00000070348 Ccnd1 / P25322 / G1/S-specific cyclin-D1 / P24385* / cyclin D1*  / reaction
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / complex / reaction
 ENSMUSG00000029765 Plxna4 / Q80UG2 / plexin A4 / Q9HCM2*  / reaction
 ENSMUSG00000026640 P70207 / Plxna2 / Plexin-A2 / O75051*  / reaction
 ENSMUSG00000022997 Wnt1 / P04426 / wingless-type MMTV integration site family, member 1 / P04628* / Wnt family member 1*  / complex / reaction
 ENSMUSG00000030201 Lrp6 / LDL receptor related protein 6 / O75581*  / reaction / complex
 ENSMUSG00000036961 Wnt8b / wingless-type MMTV integration site family, member 8B / Q93098* / Wnt family member 8B*  / reaction / complex
 ENSMUSG00000029071 Dvl1 / P51141 / Segment polarity DVL-1 / O14640* / dishevelled segment polarity protein 1*  / reaction / complex
 ENSMUSG00000044674 Fzd1 / O70421 / Frizzled-1 / Q9UP38* / frizzled class receptor 1*  / complex / reaction
 ENSMUSG00000050288 Fzd2 / Q9JIP6 / Frizzled-2 / Q14332* / frizzled class receptor 2*  / complex / reaction






 

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