ENSMUSG00000024182


Mus musculus

Features
Gene ID: ENSMUSG00000024182
  
Biological name :Axin1
  
Synonyms : Axin1
  
Possible biological names infered from orthology : O15169
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 26138688
Gene end: 26195811
  
Corresponding Affymetrix probe sets: 10442954 (MoGene1.0st)   1426966_at (Mouse Genome 430 2.0 Array)   1426967_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000132000
Ensembl peptide - ENSMUSP00000073974
Ensembl peptide - ENSMUSP00000113756
Ensembl peptide - ENSMUSP00000127182
NCBI entrez gene - 12005     See in Manteia.
MGI - MGI:1096327
RefSeq - XM_006523515
RefSeq - XM_006523516
RefSeq - NM_001159598
RefSeq - NM_009733
RefSeq Peptide - NP_001153070
RefSeq Peptide - NP_033863
swissprot - Q14DJ8
swissprot - F6SKQ8
swissprot - E9QMJ8
Ensembl - ENSMUSG00000024182
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 axin1ENSDARG00000102964Danio rerio
 AXIN1ENSGALG00000029402Gallus gallus
 AXIN1ENSG00000103126Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Axin2 / O88566 / Q9Y2T1*ENSMUSG0000000014241


Protein motifs (from Interpro)
Interpro ID Name
 IPR001158  DIX domain
 IPR014936  Axin beta-catenin binding
 IPR016137  RGS domain
 IPR024066  RGS, subdomain 1/3
 IPR029071  Ubiquitin-like domain superfamily
 IPR029797  Axin-1
 IPR032101  Axin-1/2, tankyrase-binding domain
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0034622 cellular protein-containing complex assembly IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0051443 positive regulation of ubiquitin-protein transferase activity IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0030877 beta-catenin destruction complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0071944 cell periphery IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030159 receptor signaling complex scaffold activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0032947 protein-containing complex scaffold activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046332 SMAD binding IEA
 molecular_functionGO:0070411 I-SMAD binding IEA


Pathways (from Reactome)
Pathway description
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
TCF dependent signaling in response to WNT
Degradation of AXIN
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Axin1tm3Cos/Axin1tm4Cos
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trhtm1Mmt/Trhtm1Mmt
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Axin1Fu/Axin1Fu
Genetic Background: Not Specified

Allelic Composition: Axin1Fu-ki/Axin1+
Genetic Background: mixed

 MP:0000151 absent rib "missing the pairs of bony structures that make up the body wall" [J:19212]
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Allelic Composition: Trhtm1Mmt/Trhtm1Mmt
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Axin1Fu/Axin1Fu
Genetic Background: Not Specified

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
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Allelic Composition: Trhtm1Mmt/Trhtm1Mmt
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Axin1Fu/Axin1Fu
Genetic Background: Not Specified

Allelic Composition: Axin1Fu-ki/Axin1+
Genetic Background: mixed

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Axin1Fu-ki/Axin1Fu-Tg1
Genetic Background: involves: BTBR * C57BL/6J * CBA/J

Allelic Composition: Axin1tm3Cos/Axin1tm3Cos
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Axin1tm4Cos/Axin1tm4Cos
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Axin1tm3Cos/Axin1tm4Cos
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0000435 shortened head "reduced anterior-posterior length of the head" [J:42035]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Axin1tm3Cos/Axin1tm3Cos
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Axin1tm4Cos/Axin1tm4Cos
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Trhtm1Mmt/Trhtm1Mmt
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Axin1Fu/Axin1Fu
Genetic Background: Not Specified

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trhtm1Mmt/Trhtm1Mmt
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Axin1Fu/Axin1Fu
Genetic Background: Not Specified

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Trhtm1Mmt/Trhtm1Mmt
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Axin1Fu/Axin1Fu
Genetic Background: Not Specified

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Axin1Fu-ki/Axin1+
Genetic Background: mixed

Allelic Composition: Axin1Fu-kb/Axin1+
Genetic Background: Not Specified

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Axin1Fu/Axin1Fu
Genetic Background: Not Specified

Allelic Composition: Axin1Fu-ki/Axin1+
Genetic Background: mixed

 MP:0000784 forebrain hypoplasia "reduced cell number in the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Axin1tm3Cos/Axin1tm3Cos
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Axin1tm4Cos/Axin1tm4Cos
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Axin1tm3Cos/Axin1tm4Cos
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Axin1tm3Cos/Axin1tm3Cos
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Trhtm1Mmt/Trhtm1Mmt
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Axin1Fu/Axin1Fu
Genetic Background: Not Specified

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trhtm1Mmt/Trhtm1Mmt
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Axin1Fu/Axin1Fu
Genetic Background: Not Specified

Allelic Composition: Axin1Fu-ki/Axin1+
Genetic Background: mixed

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: B6.129S4-Ptpn11tm1Bgn

Allelic Composition: Axin1tm3Cos/Axin1tm4Cos
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Axin1Fu-ki/Axin1+
Genetic Background: mixed

 MP:0001684 abnormal axial mesoderm "malformed middle primary germ layer" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:51834]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Axin1tm3Cos/Axin1tm3Cos
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Axin1tm4Cos/Axin1tm4Cos
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Axin1tm1.2Dic/Axin1tm1.2Dic
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Axin1tm3Cos/Axin1tm3Cos
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Axin1Fu-ki/Axin1Fu-Tg1
Genetic Background: involves: BTBR * C57BL/6J * CBA/J

Allelic Composition: Axin1Fu-ki/Axin1Fu-ki
Genetic Background: involves: Bagg albino * CF * fanciers mice

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Trhtm1Mmt/Trhtm1Mmt
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Axin1Fu/Axin1Fu
Genetic Background: Not Specified

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Axin1Fu-ki/Axin1+
Genetic Background: mixed

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Axin1Fu-ki/Axin1+
Genetic Background: mixed

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Axin1Fu-ki/Axin1Fu-ki
Genetic Background: involves: Bagg albino * CF * fanciers mice

Allelic Composition: Axin1tm1.2Dic/Axin1tm1.2Dic
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Axin1Fu-ki/Axin1Fu-ki
Genetic Background: involves: Bagg albino * CF * fanciers mice

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trhtm1Mmt/Trhtm1Mmt
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trhtm1Mmt/Trhtm1Mmt
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Axin1Fu/Axin1Fu
Genetic Background: Not Specified

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trhtm1Mmt/Trhtm1Mmt
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Axin1Fu/Axin1Fu
Genetic Background: Not Specified

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Axin1tm3Cos/Axin1tm4Cos
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gjc1tm1Kwi/Gjc1tm1Weil,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Axin1tm2Cos/Axin1tm2Cos
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Axin1Fu-Tg1/Axin1tm1(Axin2)Cos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB/N

Allelic Composition: Axin1tm1.1Dic/Axin1tm1.1Dic
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Axin1Fu/Axin1+
Genetic Background: involves: M. m. bactrianus

 MP:0002233 abnormal nose morphology "any structural anomaly of the organ that is specialized for smell and is part of the respiratory system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Axin1tm4Cos/Axin1tm4Cos,Ctnnb1tm2.1Kem/Ctnnb1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002759 abnormal caudal vertebrae morphology "malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]
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Allelic Composition: Trhtm1Mmt/Trhtm1Mmt
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Axin1Fu/Axin1Fu
Genetic Background: Not Specified

Allelic Composition: Axin1Fu-ki/Axin1+
Genetic Background: mixed

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Axin1Fu-ki/Axin1+
Genetic Background: mixed

 MP:0003049 abnormal lumbar vertebrae morphology "malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Axin1Fu-ki/Axin1+
Genetic Background: mixed

 MP:0003050 abnormal sacral vertebrae morphology "malformation of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Axin1Fu-ki/Axin1+
Genetic Background: mixed

 MP:0003121 genomic imprinting "phenotype resulting from inactivation of specific loci during gametogenesis, but not encoded by the DNA itself" [llw2:Linda Washburn, Mouse Genome Informatics Curator, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Ednrbs-2MLPl/Ednrb+
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Axin1Fu/Axin1+
Genetic Background: involves: 129/Rr * C3H/He * C57BL/6J

Allelic Composition: Axin1Fu/Axin1+
Genetic Background: involves: 129/Rr * C3H/He * C57BL/6J * wild

Allelic Composition: Avy/a,Axin1Fu/Axin1+
Genetic Background: involves: 129P4/RrRk * C67BL/6J

 MP:0003122 maternal imprinting "specific loci are inactivated during oogenesis and are not expressed in offspring" [llw2:Linda Washburn, Mouse Genome Informatics Curator, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Ednrbs-2MLPl/Ednrb+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0003123 paternal imprinting "specific loci are inactivated during spermatogenesis and are not expressed in offspring " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator, llw2:Linda Washburn, Mouse Genome Informatics Curator]
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Allelic Composition: Slc17a8tm1Edw/Slc17a8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Axin1Fu/Axin1+
Genetic Background: 129P4.Cg-Axin1Fu/J

Allelic Composition: Axin1Fu/Axin1+
Genetic Background: involves: 129/Rr * C3H/He * C57BL/6J

 MP:0003176 reversion by viral sequence excision "restoration of wild-type phenotype by removal of a viral sequence or a viral- related sequence that produced a mutant phenotype" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-Btlr/KitW-Btlr
Genetic Background: C57BL/6J-KitW-Btlr

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Axin1Fu-ki/Axin1Fu-ki
Genetic Background: involves: BTBR

Allelic Composition: Axin1tm3Cos/Axin1tm3Cos
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0003591 urethra atresia "closure, or failure to develop a connection in the canal that leads from the bladder and discharges urine externally" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Trhtm1Mmt/Trhtm1Mmt
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Axin1Fu/Axin1Fu
Genetic Background: Not Specified

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trhtm1Mmt/Trhtm1Mmt
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Axin1Fu/Axin1Fu
Genetic Background: Not Specified

 MP:0003722 absent ureter "missing the tube that conducts the urine from the renal pelvis to the bladder" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Axin1Fu/Axin1Fu
Genetic Background: Not Specified

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Axin1tm4Cos/Axin1tm4Cos,Ctnnb1tm2.1Kem/Ctnnb1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Axin1Fu-ki/Axin1Fu-Tg1
Genetic Background: involves: BTBR * C57BL/6J * CBA/J

Allelic Composition: Axin1Fu-ki/Axin1Fu-ki
Genetic Background: involves: Bagg albino * CF * fanciers mice

Allelic Composition: Axin1tm3Cos/Axin1tm3Cos
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Axin1tm4Cos/Axin1tm4Cos
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Axin1tm3Cos/Axin1tm4Cos
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0003988 disorganized embryonic tissue "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]
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Allelic Composition: Axin1Fu-ki/Axin1Fu-ki
Genetic Background: involves: Bagg albino * CF * fanciers mice

 MP:0004187 cardia bifida "failure of the bilateral myocardial cells to coalesce into a single central heart tube resulting in the presence of two independent hearts" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Axin1tm3Cos/Axin1tm3Cos
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Axin1tm4Cos/Axin1tm4Cos
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0004619 caudal vertebral fusion "the union of one or more caudal vertebrae into a single structure in species where this does not normally occur" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Axin1Fu-ki/Axin1+
Genetic Background: mixed

 MP:0004621 lumbar vertebral fusion "the union of one or more lumbar vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Axin1Fu-ki/Axin1+
Genetic Background: mixed

 MP:0004622 sacral vertebral fusion "the union of one or more sacral vertebrae into a single structure in species where this does not normally occur" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Axin1Fu-ki/Axin1+
Genetic Background: mixed

 MP:0004623 thoracic vertebral fusion "the union of one or more thoracic vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Axin1Fu-ki/Axin1+
Genetic Background: mixed

 MP:0004713 split notochord "the appearance of an abnormal division in the axial fibrocellular cord in embryos around which develops the vertebral primordia" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Axin1Fu-ki/Axin1Fu-ki
Genetic Background: involves: Bagg albino * CF * fanciers mice

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Axin1tm1.2Dic/Axin1tm1.2Dic
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0009352 impaired spacing of implantation sites "in organisms which give birth to multiple offspring in one litter, blastocysts fail to implant at intervals conducive to the formation of a normal enveloping membrane or decidua for each conceptus from the epithelial tissue of the endometrium lining of the uterus" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Axin1Fu-ki/Axin1+
Genetic Background: mixed

 MP:0009353 twin decidual capsule "two embryos share one decidual membrane" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Axin1Fu-ki/Axin1+
Genetic Background: mixed

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Axin1Fu-ki/Axin1+
Genetic Background: mixed

Allelic Composition: Axin1tm4Cos/Axin1tm4Cos
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Axin1tm3Cos/Axin1tm4Cos
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Axin1Fu-ki/Axin1Fu-ki
Genetic Background: involves: Bagg albino * CF * fanciers mice

Allelic Composition: Axin1tm3Cos/Axin1tm3Cos
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0011199 abnormal amniotic cavity morphology "any structural anomaly of the closed space between the embryo and the amnion, containing the amniotic fluid; it is formed by the fusion of the parts of the anterior and posterior amniotic folds" [ISBN:0-12-402035-6]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011259 abnormal cephalic neural fold morphology "any structural anomaly of the elevated margins of the neural groove that are located in the future cephalic region of the embryo" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Axin1Fu-ki/Axin1Fu-ki
Genetic Background: involves: BTBR

Allelic Composition: Axin1Fu-ki/Axin1Fu-Tg1
Genetic Background: involves: BTBR * C57BL/6J * CBA/J

 MP:0011775 rectal atresia "congenital absence, closure, or constriction of the lumen of the terminal portion of the intestinal tube adjacent to the anus, leading to abdominal distention after birth" [MGI:anna]
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Allelic Composition: Trhtm1Mmt/Trhtm1Mmt
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Axin1Fu/Axin1Fu
Genetic Background: Not Specified

 MP:0011999 abnormal tail length "any anomaly in the length of tail relative to average of a given reference population" [MGI:csmith]
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Allelic Composition: Trhtm1Mmt/Trhtm1Mmt
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0012062 small tail bud "decreased size or area of the primordial region of the embryo that arises to form the tail of the adult" [MGI:anna]
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Allelic Composition: Axin1Fu-ki/Axin1Fu-ki
Genetic Background: involves: Bagg albino * CF * fanciers mice

 MP:0012104 small amniotic cavity "reduced size of the closed space between the embryo and the amnion which contains the amniotic fluid and is formed by the fusion of the parts of the anterior and posterior amniotic folds" [MGI:anna]
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Allelic Composition: Axin1Fu-ki/Axin1+
Genetic Background: mixed

 MP:0012136 absent forebrain "absence of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012156 rostral-caudal axis duplication "partial or complete duplication of rostral-caudal axis structures" [MGI:anna]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Axin1Fu-ki/Axin1Fu-ki
Genetic Background: involves: Bagg albino * CF * fanciers mice

 MP:0012174 flat head "the appearance of a flattened surface outline or contour of a normally rounded head of an organism" [MGI:anna]
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Allelic Composition: Axin1Fu-ki/Axin1Fu-Tg1
Genetic Background: involves: BTBR * C57BL/6J * CBA/J

 MP:0013175 bifurcated tail "the appearance of an abnormal division in the flexible elongated appendage located at the caudal end of the torso in many species" [MGI:anna]
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Allelic Composition: Trhtm1Mmt/Trhtm1Mmt
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Axin1Fu/Axin1Fu
Genetic Background: Not Specified

Allelic Composition: Axin1Fu-ki/Axin1+
Genetic Background: mixed

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003233 Dvl3 / Q61062 / Segment polarity DVL-3 / Q92997* / dishevelled segment polarity protein 3*  / complex / reaction
 ENSMUSG00000009900 Wnt3a / P27467 / wingless-type MMTV integration site family, member 3A / P56704* / Wnt family member 3A*  / complex / reaction
 ENSMUSG00000012282 Wnt8a / Q64527 / wingless-type MMTV integration site family, member 8A / Q9H1J5* / Wnt family member 8A*  / complex / reaction
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / reaction / complex
 ENSMUSG00000022812 Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*  / complex
 ENSMUSG00000024811 Tnks2 / Q3UES3 / Tankyrase-2 / Q9H2K2*  / reaction / complex
 ENSMUSG00000022997 Wnt1 / P04426 / wingless-type MMTV integration site family, member 1 / P04628* / Wnt family member 1*  / complex / reaction
 ENSMUSG00000031529 Tnks / Q6PFX9 / tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase / O95271* / tankyrase*  / reaction / complex
 ENSMUSG00000030201 Lrp6 / LDL receptor related protein 6 / O75581*  / complex / reaction
 ENSMUSG00000038876 Q9CZW6 / Rnf146 / ring finger protein 146 / Q9NTX7*  / reaction / complex
 ENSMUSG00000036961 Wnt8b / wingless-type MMTV integration site family, member 8B / Q93098* / Wnt family member 8B*  / complex / reaction
 ENSMUSG00000029071 Dvl1 / P51141 / Segment polarity DVL-1 / O14640* / dishevelled segment polarity protein 1*  / complex / reaction
 ENSMUSG00000044674 Fzd1 / O70421 / Frizzled-1 / Q9UP38* / frizzled class receptor 1*  / reaction / complex
 ENSMUSG00000050288 Fzd2 / Q9JIP6 / Frizzled-2 / Q14332* / frizzled class receptor 2*  / complex / reaction
 ENSMUSG00000018363 A2A5Z6 / Smurf2 / E3 ubiquitin-protein ligase SMURF2 / Q9HAU4* / SMAD specific E3 ubiquitin protein ligase 2*  / complex / reaction
 ENSMUSG00000056342 Usp34 / Q6ZQ93 / ubiquitin specific peptidase 34 / Q70CQ2*  / reaction






 

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