ENSMUSG00000012282


Mus musculus

Features
Gene ID: ENSMUSG00000012282
  
Biological name :Wnt8a
  
Synonyms : Q64527 / wingless-type MMTV integration site family, member 8A / Wnt8a
  
Possible biological names infered from orthology : Q9H1J5 / Wnt family member 8A
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: B1
Gene start: 34542313
Gene end: 34548273
  
Corresponding Affymetrix probe sets: 10454701 (MoGene1.0st)   1422228_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000012426
NCBI entrez gene - 20890     See in Manteia.
MGI - MGI:107924
RefSeq - NM_009290
RefSeq Peptide - NP_033316
swissprot - Q64527
Ensembl - ENSMUSG00000012282
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnt8aENSDARG00000078507Danio rerio
 wnt8aENSDARG00000052910Danio rerio
 WNT8AENSGALG00000037494Gallus gallus
 WNT8AENSG00000061492Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wnt8b / wingless-type MMTV integration site family, member 8B / Q93098* / Wnt family member 8B*ENSMUSG0000003696157
P70701 / Wnt10a / wingless-type MMTV integration site family, member 10A / Q9GZT5* / Wnt family member 10A*ENSMUSG0000002616734
P48614 / Wnt10b / wingless-type MMTV integration site family, member 10B / O00744* / Wnt family member 10B*ENSMUSG0000002299633
Wnt9b / O35468 / wingless-type MMTV integration site family, member 9B / O14905* / Wnt family member 9B*ENSMUSG0000001848632
Wnt9a / Q8R5M2 / wingless-type MMTV integration site family, member 9A / O14904* / Wnt family member 9A*ENSMUSG0000000012630


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR013301  Wnt-8 protein
 IPR018161  Wnt protein, conserved site
 IPR034312  Protein Wnt-8A/8C


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0003002 regionalization IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007492 endoderm development IMP
 biological_processGO:0009949 polarity specification of anterior/posterior axis IMP
 biological_processGO:0010085 polarity specification of proximal/distal axis IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016055 Wnt signaling pathway IBA
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0032880 regulation of protein localization IMP
 biological_processGO:0045165 cell fate commitment IBA
 biological_processGO:0048561 establishment of animal organ orientation IMP
 biological_processGO:0060021 roof of mouth development ISO
 biological_processGO:0060070 canonical Wnt signaling pathway ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005109 frizzled binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0048018 receptor ligand activity ISO


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking
Disassembly of the destruction complex and recruitment of AXIN to the membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gsk3btm1Grc/Gsk3b+
Genetic Background: involves: 129S6/SvEvTac

 MP:0006011 abnormal endolymphatic duct morphology "any structural alteration in the small membranous canal, connecting with both saccule and utricle of the membranous labyrinth, passing through the aqueduct of vestibule, and terminating in the endolymphatic sac." [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gsk3btm1Grc/Gsk3b+
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003233 Dvl3 / Q61062 / Segment polarity DVL-3 / Q92997* / dishevelled segment polarity protein 3*  / complex
 ENSMUSG00000044674 Fzd1 / O70421 / Frizzled-1 / Q9UP38* / frizzled class receptor 1*  / complex
 ENSMUSG00000022812 Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*  / complex / reaction
 ENSMUSG00000030201 Lrp6 / LDL receptor related protein 6 / O75581*  / complex
 ENSMUSG00000024182 Axin1 / O15169*  / reaction / complex
 ENSMUSG00000050288 Fzd2 / Q9JIP6 / Frizzled-2 / Q14332* / frizzled class receptor 2*  / complex
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / complex
 ENSMUSG00000029071 Dvl1 / P51141 / Segment polarity DVL-1 / O14640* / dishevelled segment polarity protein 1*  / complex






 

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