ENSMUSG00000022996


Mus musculus

Features
Gene ID: ENSMUSG00000022996
  
Biological name :Wnt10b
  
Synonyms : P48614 / wingless-type MMTV integration site family, member 10B / Wnt10b
  
Possible biological names infered from orthology : O00744 / Wnt family member 10B
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F1
Gene start: 98770712
Gene end: 98778150
  
Corresponding Affymetrix probe sets: 10432267 (MoGene1.0st)   1426091_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154513
Ensembl peptide - ENSMUSP00000023732
Ensembl peptide - ENSMUSP00000131056
Ensembl peptide - ENSMUSP00000153817
Ensembl peptide - ENSMUSP00000153930
Ensembl peptide - ENSMUSP00000154384
Ensembl peptide - ENSMUSP00000154394
NCBI entrez gene - 22410     See in Manteia.
MGI - MGI:108061
RefSeq - XM_006520892
RefSeq - XM_006520893
RefSeq - NM_011718
RefSeq - XM_006520891
RefSeq Peptide - NP_035848
swissprot - Q1RME7
swissprot - P48614
Ensembl - ENSMUSG00000022996
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnt10bENSDARG00000040925Danio rerio
 O00744ENSG00000169884Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P70701 / Wnt10a / wingless-type MMTV integration site family, member 10A / Q9GZT5* / Wnt family member 10A*ENSMUSG0000002616761
Wnt9b / O35468 / wingless-type MMTV integration site family, member 9B / O14905* / Wnt family member 9B*ENSMUSG0000001848633
Wnt9a / Q8R5M2 / wingless-type MMTV integration site family, member 9A / O14904* / Wnt family member 9A*ENSMUSG0000000012632
Wnt8a / Q64527 / wingless-type MMTV integration site family, member 8A / Q9H1J5* / Wnt family member 8A*ENSMUSG0000001228230
Wnt8b / wingless-type MMTV integration site family, member 8B / Q93098* / Wnt family member 8B*ENSMUSG0000003696130


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR013302  Wnt-10 protein
 IPR018161  Wnt protein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IGI
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0002062 chondrocyte differentiation IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006629 lipid metabolic process IMP
 biological_processGO:0007050 cell cycle arrest IDA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007224 smoothened signaling pathway IDA
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IDA
 biological_processGO:0014835 myoblast differentiation involved in skeletal muscle regeneration IMP
 biological_processGO:0016055 Wnt signaling pathway ISO
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0030501 positive regulation of bone mineralization IDA
 biological_processGO:0030858 positive regulation of epithelial cell differentiation IDA
 biological_processGO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043403 skeletal muscle tissue regeneration IMP
 biological_processGO:0045165 cell fate commitment IBA
 biological_processGO:0045598 regulation of fat cell differentiation IMP
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IDA
 biological_processGO:0045778 positive regulation of ossification IMP
 biological_processGO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048641 regulation of skeletal muscle tissue development IMP
 biological_processGO:0048741 skeletal muscle fiber development IMP
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IDA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0050909 sensory perception of taste IMP
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0051246 regulation of protein metabolic process IMP
 biological_processGO:0051885 positive regulation of timing of anagen IDA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060346 bone trabecula formation IMP
 biological_processGO:0061196 fungiform papilla development IMP
 biological_processGO:0071310 cellular response to organic substance IDA
 biological_processGO:0071320 cellular response to cAMP IDA
 biological_processGO:0071374 cellular response to parathyroid hormone stimulus IDA
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 biological_processGO:0071425 hematopoietic stem cell proliferation IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005109 frizzled binding IBA


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000733 abnormal muscle development "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abca5tm1Akya/Abca5tm1Akya
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * ICR

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
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Allelic Composition: Abca5tm1Akya/Abca5tm1Akya
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * ICR

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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