ENSMUSG00000000126


Mus musculus

Features
Gene ID: ENSMUSG00000000126
  
Biological name :Wnt9a
  
Synonyms : Q8R5M2 / wingless-type MMTV integration site family, member 9A / Wnt9a
  
Possible biological names infered from orthology : O14904 / Wnt family member 9A
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.3
Gene start: 59306928
Gene end: 59333552
  
Corresponding Affymetrix probe sets: 10376490 (MoGene1.0st)   1425889_at (Mouse Genome 430 2.0 Array)   1436978_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000128
Ensembl peptide - ENSMUSP00000104411
NCBI entrez gene - 216795     See in Manteia.
MGI - MGI:2446084
RefSeq - NM_139298
RefSeq - XM_006532855
RefSeq Peptide - NP_647459
swissprot - J3JS28
swissprot - Q8R5M2
Ensembl - ENSMUSG00000000126
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnt9aENSDARG00000063437Danio rerio
 WNT9AENSGALG00000005401Gallus gallus
 WNT9AENSG00000143816Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wnt9b / O35468 / wingless-type MMTV integration site family, member 9B / O14905* / Wnt family member 9B*ENSMUSG0000001848660
P48614 / Wnt10b / wingless-type MMTV integration site family, member 10B / O00744* / Wnt family member 10B*ENSMUSG0000002299634
P70701 / Wnt10a / wingless-type MMTV integration site family, member 10A / Q9GZT5* / Wnt family member 10A*ENSMUSG0000002616733
Wnt8b / wingless-type MMTV integration site family, member 8B / Q93098* / Wnt family member 8B*ENSMUSG0000003696132
Wnt8a / Q64527 / wingless-type MMTV integration site family, member 8A / Q9H1J5* / Wnt family member 8A*ENSMUSG0000001228229


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR013303  Wnt-9a protein
 IPR018161  Wnt protein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007093 mitotic cell cycle checkpoint IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0032331 negative regulation of chondrocyte differentiation IMP
 biological_processGO:0035115 embryonic forelimb morphogenesis IDA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0045165 cell fate commitment IBA
 biological_processGO:0045597 positive regulation of cell differentiation IMP
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IMP
 biological_processGO:0048704 embryonic skeletal system morphogenesis IMP
 biological_processGO:0048856 anatomical structure development IGI
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060548 negative regulation of cell death IDA
 biological_processGO:0061037 negative regulation of cartilage development IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005109 frizzled binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0048018 receptor ligand activity IEA


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000078 abnormal supraoccipital bone morphology "malformed upper part of the occipital bone" [J:61509]
Show

Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Wnt9atm2Chha/Wnt9atm2Chha
Genetic Background: involves: 129X1/SvJ

 MP:0000079 abnormal basioccipital bone morphology "malformed basilar process of the occipital bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Wnt9atm2Chha/Wnt9atm2Chha
Genetic Background: involves: 129X1/SvJ

 MP:0000107 abnormal frontal bone morphology "malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Wnt9atm2Chha/Wnt9atm2Chha
Genetic Background: involves: 129X1/SvJ

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Wnt9atm2Chha/Wnt9atm2Chha
Genetic Background: involves: 129X1/SvJ

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Wnt9atm2Chha/Wnt9atm2Chha
Genetic Background: involves: 129X1/SvJ

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Wnt9atm2Chha/Wnt9atm2Chha
Genetic Background: involves: 129X1/SvJ

 MP:0003189 fused joints 
Show

Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Wnt9atm2Chha/Wnt9atm2Chha
Genetic Background: involves: 129X1/SvJ

 MP:0003843 abnormal sagittal suture morphology "malformation of the articulation between the parietal bones" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Wnt9atm2Chha/Wnt9atm2Chha
Genetic Background: involves: 129X1/SvJ

 MP:0003869 ectopic cartilage "positional abnormality of cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Wnt9atm2Chha/Wnt9atm2Chha
Genetic Background: involves: 129X1/SvJ

 MP:0004447 small basioccipital bone "reduced size of the bone in the base of the cranium, frequently forming a part of the occipital in the adult, but usually distinct in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Wnt9atm2Chha/Wnt9atm2Chha
Genetic Background: involves: 129X1/SvJ

 MP:0004607 abnormal cervical atlas morphology "any structural anomaly of the first (topmost, C1) cervical vertebra which supports the globe of the head" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Wnt9atm2Chha/Wnt9atm2Chha
Genetic Background: involves: 129X1/SvJ

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Wnt9atm2Chha/Wnt9atm2Chha
Genetic Background: involves: 129X1/SvJ

 MP:0008818 abnormal interfrontal bone morphology "any structural anomaly or presence of a bone between the frontal bones in the skull; an extra bony plate within the anterior fontanelle that is not usually present" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Wnt9atm2Chha/Wnt9atm2Chha
Genetic Background: involves: 129X1/SvJ

 MP:0009780 abnormal chondrocyte physiology "any functional anomaly of nondividing cartilage cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Wnt9atm2Chha/Wnt9atm2Chha
Genetic Background: involves: 129X1/SvJ

 MP:0009899 hyoid bone hypoplasia "underdevelopment of the hyoid bone, usually due to a deficiency in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Wnt9atm2Chha/Wnt9atm2Chha
Genetic Background: involves: 129X1/SvJ

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Wnt9atm2Chha/Wnt9atm2Chha
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020218 Wif1 / Q9WUA1 / Wnt inhibitory factor 1 / Q9Y5W5*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr