ENSG00000143816


Homo sapiens

Features
Gene ID: ENSG00000143816
  
Biological name :WNT9A
  
Synonyms : O14904 / WNT9A / Wnt family member 9A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q42.13
Gene start: 227918656
Gene end: 227947898
  
Corresponding Affymetrix probe sets: 1553045_at (Human Genome U133 Plus 2.0 Array)   230643_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000272164
NCBI entrez gene - 7483     See in Manteia.
OMIM - 602863
RefSeq - XM_011544271
RefSeq - NM_003395
RefSeq Peptide - NP_003386
swissprot - O14904
swissprot - D9ZGG3
Ensembl - ENSG00000143816
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnt9aENSDARG00000063437Danio rerio
 WNT9AENSGALG00000005401Gallus gallus
 Wnt9aENSMUSG00000000126Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WNT9B / O14905 / Wnt family member 9BENSG0000015895560
O00744 / WNT10B / Wnt family member 10BENSG0000016988435
Q9GZT5 / WNT10A / Wnt family member 10AENSG0000013592534
WNT8B / Q93098 / Wnt family member 8BENSG0000007529033
WNT8A / Q9H1J5 / Wnt family member 8AENSG0000006149230


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR013303  Wnt-9a protein
 IPR018161  Wnt protein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007093 mitotic cell cycle checkpoint IMP
 biological_processGO:0007267 cell-cell signaling NAS
 biological_processGO:0007275 multicellular organism development NAS
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016055 Wnt signaling pathway IBA
 biological_processGO:0030182 neuron differentiation ISS
 biological_processGO:0032331 negative regulation of chondrocyte differentiation ISS
 biological_processGO:0035115 embryonic forelimb morphogenesis IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0045165 cell fate commitment IBA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IEA
 biological_processGO:0048704 embryonic skeletal system morphogenesis IEA
 biological_processGO:0048856 anatomical structure development IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IDA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0061037 negative regulation of cartilage development IEA
 biological_processGO:0061072 iris morphogenesis ISS
 biological_processGO:0061303 cornea development in camera-type eye ISS
 biological_processGO:0071300 cellular response to retinoic acid ISS
 biological_processGO:0072498 embryonic skeletal joint development ISS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005109 frizzled binding IBA
 molecular_functionGO:0048018 receptor ligand activity IDA


Pathways (from Reactome)
Pathway description
TCF dependent signaling in response to WNT
WNT ligand biogenesis and trafficking
Class B/2 (Secretin family receptors)
Negative regulation of TCF-dependent signaling by WNT ligand antagonists


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000156076 WIF1 / Q9Y5W5 / WNT inhibitory factor 1  / complex / reaction






 

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