Manteia

ENSG00000075290

Homo sapiens

Features

Gene ID:	ENSG00000075290

Biological name :	WNT8B

Synonyms :	Q93098 / WNT8B / Wnt family member 8B

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	10
Strand:	1
Band:	q24.31
Gene start:	100463041
Gene end:	100483744

Corresponding Affymetrix probe sets:	207612_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000340677 NCBI entrez gene - 7479 See in Manteia. OMIM - 601396 RefSeq - NM_003393 RefSeq Peptide - NP_003384 swissprot - Q93098 Ensembl - ENSG00000075290

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
wnt8b	ENSDARG00000006911	Danio rerio
WNT8B	ENSGALG00000005733	Gallus gallus
Wnt8b	ENSMUSG00000036961	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
WNT8A / Q9H1J5 / Wnt family member 8A	ENSG00000061492	63
Q9GZT5 / WNT10A / Wnt family member 10A	ENSG00000135925	35
WNT9A / O14904 / Wnt family member 9A	ENSG00000143816	34
WNT9B / O14905 / Wnt family member 9B	ENSG00000158955	34
O00744 / WNT10B / Wnt family member 10B	ENSG00000169884	33

Protein motifs (from Interpro)

Interpro ID	Name
IPR005817	Wnt
IPR013301	Wnt-8 protein
IPR018161	Wnt protein, conserved site
IPR034311	Protein Wnt-8B

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007165	signal transduction	TAS
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007369	gastrulation	ISS
biological_process	GO:0007399	nervous system development	TAS
biological_process	GO:0010469	regulation of signaling receptor activity	IEA
biological_process	GO:0016055	Wnt signaling pathway	IBA
biological_process	GO:0030182	neuron differentiation	ISS
biological_process	GO:0032355	response to estradiol	NAS
biological_process	GO:0032526	response to retinoic acid	NAS
biological_process	GO:0045165	cell fate commitment	IBA
biological_process	GO:0048263	determination of dorsal identity	ISS
biological_process	GO:0060070	canonical Wnt signaling pathway	IDA
biological_process	GO:0071300	cellular response to retinoic acid	ISS
biological_process	GO:1904886	beta-catenin destruction complex disassembly	TAS
cellular_component	GO:0005576	extracellular region	TAS
cellular_component	GO:0005615	extracellular space	IBA
molecular_function	GO:0005102	signaling receptor binding	IEA
molecular_function	GO:0005109	frizzled binding	IBA
molecular_function	GO:0048018	receptor ligand activity	IDA

Pathways (from Reactome)

Pathway description

TCF dependent signaling in response to WNT

WNT ligand biogenesis and trafficking

Class B/2 (Secretin family receptors)

Disassembly of the destruction complex and recruitment of AXIN to the membrane

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000004975	DVL2 / O14641 / dishevelled segment polarity protein 2	/ reaction / complex
ENSG00000082701	GSK3B / P49841 / glycogen synthase kinase 3 beta	/ complex / reaction
ENSG00000103126	AXIN1 / O15169	/ complex / reaction
ENSG00000161202	DVL3 / Q92997 / dishevelled segment polarity protein 3	/ complex / reaction
ENSG00000157240	FZD1 / Q9UP38 / frizzled class receptor 1	/ reaction / complex
ENSG00000180340	FZD2 / Q14332 / frizzled class receptor 2	/ reaction / complex
ENSG00000070018	LRP6 / O75581 / LDL receptor related protein 6	/ complex / reaction
ENSG00000107404	DVL1 / O14640 / dishevelled segment polarity protein 1	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr