ENSG00000157240


Homo sapiens

Features
Gene ID: ENSG00000157240
  
Biological name :FZD1
  
Synonyms : frizzled class receptor 1 / FZD1 / Q9UP38
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q21.13
Gene start: 91264364
Gene end: 91271326
  
Corresponding Affymetrix probe sets: 204451_at (Human Genome U133 Plus 2.0 Array)   204452_s_at (Human Genome U133 Plus 2.0 Array)   236035_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000287934
NCBI entrez gene - 8321     See in Manteia.
OMIM - 603408
RefSeq - NM_003505
RefSeq Peptide - NP_003496
swissprot - Q9UP38
Ensembl - ENSG00000157240
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fzd1ENSDARG00000106062Danio rerio
 FZD1ENSGALG00000009064Gallus gallus
 Fzd1ENSMUSG00000044674Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FZD2 / Q14332 / frizzled class receptor 2ENSG0000018034070
FZD7 / O75084 / frizzled class receptor 7ENSG0000015576069
FZD8 / Q9H461 / frizzled class receptor 8ENSG0000017728343
FZD5 / Q13467 / frizzled class receptor 5ENSG0000016325142
FZD10 / Q9ULW2 / frizzled class receptor 10ENSG0000011143240
FZD9 / O00144 / frizzled class receptor 9ENSG0000018876339
FZD4 / Q9ULV1 / frizzled class receptor 4ENSG0000017480437
FZD3 / Q9NPG1 / frizzled class receptor 3ENSG0000010429037
FZD6 / O60353 / frizzled class receptor 6ENSG0000016493036
SMO / Q99835 / smoothened, frizzled class receptorENSG0000012860223
SFRP4 / Q6FHJ7 / secreted frizzled related protein 4ENSG0000010648314
SFRP1 / Q8N474 / secreted frizzled related protein 1ENSG0000010433213
FRZB / Q92765 / frizzled related proteinENSG0000016299813
SFRP5 / Q5T4F7 / secreted frizzled related protein 5ENSG0000012005713
SFRP2 / Q96HF1 / secreted frizzled related protein 2ENSG0000014542311


Protein motifs (from Interpro)
Interpro ID Name
 IPR000539  Frizzled/Smoothened, transmembrane domain
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR017981  GPCR, family 2-like
 IPR020067  Frizzled domain
 IPR026548  Frizzled-1
 IPR036790  Frizzled cysteine-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0003149 membranous septum morphogenesis IEA
 biological_processGO:0003150 muscular septum morphogenesis IEA
 biological_processGO:0003151 outflow tract morphogenesis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010976 positive regulation of neuron projection development ISS
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030182 neuron differentiation ISS
 biological_processGO:0030514 negative regulation of BMP signaling pathway IEA
 biological_processGO:0030855 epithelial cell differentiation IEA
 biological_processGO:0035425 autocrine signaling IDA
 biological_processGO:0035567 non-canonical Wnt signaling pathway IBA
 biological_processGO:0042493 response to drug IMP
 biological_processGO:0044338 canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation IMP
 biological_processGO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0060022 hard palate development IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway TAS
 biological_processGO:0060412 ventricular septum morphogenesis IEA
 biological_processGO:0090179 planar cell polarity pathway involved in neural tube closure IEA
 biological_processGO:0099054 presynapse assembly TAS
 biological_processGO:1903204 negative regulation of oxidative stress-induced neuron death IEA
 biological_processGO:1904886 beta-catenin destruction complex disassembly TAS
 biological_processGO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation NAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:1990909 Wnt signalosome IC
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005109 frizzled binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017147 Wnt-protein binding IEA
 molecular_functionGO:0030165 PDZ domain binding IPI
 molecular_functionGO:0042813 Wnt-activated receptor activity TAS


Pathways (from Reactome)
Pathway description
TCF dependent signaling in response to WNT
Class B/2 (Secretin family receptors)
PCP/CE pathway
Asymmetric localization of PCP proteins
Disassembly of the destruction complex and recruitment of AXIN to the membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000004975 DVL2 / O14641 / dishevelled segment polarity protein 2  / reaction / complex
 ENSG00000082701 GSK3B / P49841 / glycogen synthase kinase 3 beta  / reaction / complex
 ENSG00000070018 LRP6 / O75581 / LDL receptor related protein 6  / complex / reaction
 ENSG00000103126 AXIN1 / O15169  / reaction / complex
 ENSG00000154342 WNT3A / P56704 / Wnt family member 3A  / complex / reaction
 ENSG00000161202 DVL3 / Q92997 / dishevelled segment polarity protein 3  / complex / reaction
 ENSG00000125084 WNT1 / P04628 / Wnt family member 1  / reaction / complex
 ENSG00000085741 WNT11 / O96014 / Wnt family member 11  / complex / reaction
 ENSG00000075290 WNT8B / Q93098 / Wnt family member 8B  / reaction / complex
 ENSG00000061492 WNT8A / Q9H1J5 / Wnt family member 8A  / reaction / complex
 ENSG00000107404 DVL1 / O14640 / dishevelled segment polarity protein 1  / complex / reaction






 

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